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#1Yanxiang Wang (HAU: Huazhong Agricultural University)H-Index: 2
#2Lifeng Zhai (Yangtze Normal University)
Last.Ni Hong (HAU: Huazhong Agricultural University)H-Index: 14
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Abstract Viruses in the genus Emaravirus contain 5–8 negative genomic RNAs and cause severe diseases of plants. In this study, a novel emaravirus, provisionally named Actinidia emaravirus 2 (AcEV-2), was identified from a kiwifruit tree showing leaf mottle and chlorosis symptoms. The genome of AcEV-2 consisted of at least six RNAs (RNAs 1–6) with sizes of 7079, 2252, 1387, 1514, 1744 and 1233 nucleotides (nts), respectively. Proteins encoded by RNAs1–4 of AcEV-2 shared the highest amino acid (aa...
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#1Merel Oeyen (Rega Institute for Medical Research)H-Index: 1
#2Sam Noppen (Rega Institute for Medical Research)H-Index: 12
Last.Dominique Schols (Rega Institute for Medical Research)H-Index: 69
view all 7 authors...
Abstract In Gordts et al. (2015), we have shown that lignosulfonic acid, a commercially available lignin derivative, possesses broad antiviral activity against human immunodeficiency virus (HIV) and Herpes simplex virus (HSV) by preventing viral entry into susceptible target cells. Because of the interesting safety profile as potential microbicide, we now determined the antiviral activity of a series of lignosulfonates in order to understand better which molecular features can contribute to thei...
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#1Tokiko Watanabe (UTokyo: University of Tokyo)H-Index: 7
#2Nobuhiro Suzuki (UTokyo: University of Tokyo)H-Index: 62
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
view all 9 authors...
Abstract Given that approximately 1031 virus particles exist on Earth and all of them are parasitic in living organisms, it is not hard to imagine how virus infection might affect the physiology of hosts and their ecosystems. However, traditional virology research tends to focus on viral pathogenicity or the individual pathogenic viruses; hence, the significance of viruses and viral-mediated processes in the global ecosystem has been poorly understood. To identify the previously unrecognized “ra...
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#1Linoy Golani-Zaidie (BIU: Bar-Ilan University)
#2Tatiana Borodianskiy-Shteinberg (BIU: Bar-Ilan University)
Last.Ronald S. Goldstein (BIU: Bar-Ilan University)H-Index: 27
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Abstract Most herpesviruses use both host and viral small non-coding RNAs (sncRNA), especially microRNA, to modulate infection. Bioinformatic analyses of NGS data obtained from Varicella Zoster virus (VZV)-infected cells predicted 24 VZVsncRNA, seven of which were confirmed to be expressed in infected fibroblasts and neurons using stem-loop quantitative reverse transcription PCR (SL-PCR). We here assayed for the expression of all 24 of the bioinformatically predicted VZVsncRNA in cells productiv...
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#1Gaby S. Steba (UvA: University of Amsterdam)H-Index: 2
#2Sylvie M. Koekkoek (UvA: University of Amsterdam)H-Index: 11
Last.William A. Paxton (University of Liverpool)H-Index: 34
view all 11 authors...
Abstract Bile-salt stimulate lipase (BSSL) is a glycoprotein found in human milk and blood that can potently bind DC-SIGN. The BSSL gene is highly polymorphic with a variant number of O-linked glycosylated 11 amino acid repeats at the C-terminus of the protein, encoded in exon 11 of the gene. It has been shown that certain BSSL genotypes associate with decreased HIV-1 transmission in vitro and decreased HIV-1 disease progression. The protein forms dimers and individuals possessing one high (typi...
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#1B. Taylan Koç (Adnan Menderes University)
#2T. Çiğdem Oğuzoğlu (Ankara University)H-Index: 1
Abstract Feline Foamy Virus (FFV) is an important retroviral agent affecting domestic cats in Turkey that has been studied less intensively than Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV). Accordingly, we aimed to investigate the presence and prevalence of FFV among domestic cats by molecular techniques. PCR was used to amplify the gag-pol gene overlap in order to detect the presence of FFV. The gene encoding bet, an important accessory gene, was also characterized. Mol...
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#1Mohamed Kamel (Cairo University)H-Index: 9
#2Amr El-Sayed (Cairo University)H-Index: 12
Abstract Peste des petits ruminants (PPR) is an acute transboundary infectious viral disease affecting domestic and wild small ruminants’ species besides camels reared in Africa, Asia and the Middle East. The virus is a serious paramount challenge to the sustainable agriculture advancement in the developing world. The disease outbreak was also detected for the first time in the European Union namely in Bulgaria at 2018. Therefore, the disease has lately been aimed for eradication with the purpos...
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#1Ibrahim M. Sayed (UCSD: University of California, San Diego)H-Index: 1
#2Amal A. Elkhawaga (Assiut University)
Last.Mohamed A. El-Mokhtar (Assiut University)H-Index: 4
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Abstract Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis globally. HEV belongs to the Hepeviridae family and at least five genotypes (gt) infect humans. Several animal species are reservoirs for different HEV strains, and they are the source of infection for humans. Some HEV strains are species specific, but other strains could cross species and infect many hosts. The study of HEV infection and pathogenesis was hampered due to the lack of an in vitro and in vivo robust ...
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#1Oleg S. Gorbatyuk (UF: University of Florida)H-Index: 19
#2Kenneth H. Warrington (UF: University of Florida)H-Index: 2
Last.Nicholas Muzyczka (UF: University of Florida)H-Index: 63
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Abstract We compared the phenotypes of three mutant AAV2 viruses containing mutations in arginine amino acids (R585, R588 and R484) previously shown to be involved in AAV2 heparan sulfate binding. The transduction efficiencies of wild type and mutant viruses were determined in the eye, the brain and peripheral organs following subretinal, striatal and intravenous injection, respectively, in mice and rats. We found that each of the three mutants (the single mutant R585A; the double mutant R585, 5...
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#1Leonardo Nazario de Moraes (UNESP: Sao Paulo State University)H-Index: 6
#2Rejane Maria Tommasini Grotto (UNESP: Sao Paulo State University)H-Index: 6
Last.Rafael Plana Simões (UNESP: Sao Paulo State University)H-Index: 4
view all 10 authors...
Abstract NS3 is an important therapeutic target for direct-acting antiviral (DAA) drugs. However, many patients treated with DAAs have unsustained virologic response (UVR) due to the high mutation rate of HCV. The aim of this work was to shed some light on the puzzling molecular mechanisms of the virus’s of patients who showed high viral loads even under treatment with DAA. Bioinformatics tools, molecular modelling analyses were employed to identify mutations associated with HCV resistance to bo...
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