Gut and Liver
Papers 1321
1 page of 133 pages (1,321 results)
#2Gang Zhou (Nanjing Medical University)
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Background/Aims: Colorectal cancer (CRC) patients often exhibit peritoneal metastasis, which negatively impacts their prognosis. CD31 and D2-40 have recently been suggested to be predictors of breast cancer prognosis, but their role in colorectal peritoneal metastasis (CRPM) remains unknown. Methods: The expression profiles of CD31 and D2-40 were analyzed in CRC patients with or without CRPM and in CRC cell lines with increasing metastatic potential. Overexpression and short hairpin RNA knockdow...
#1Han Jo Jeon (KU: Korea University)
#2Seung Min Jeong (SNU: Seoul National University)H-Index: 2
Last. Yoon Tae Jeen (KU: Korea University)H-Index: 25
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Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance and efficacy of aqueous chitosan solution and commercialized submucosal injection fluids using a three-dimensional sensor and to evaluate the efficacy of the measured parameters. Methods: Normal saline (0.9% NaCl), as a control, Eleview((R)) (Poloxamer 188), Blue Eye(TM) (0.4% hyaluronic acid),...
#1Yoo Min Han (Seoul National University Hospital)H-Index: 4
#2Jaemoon Koh (Seoul National University Hospital)H-Index: 7
Last. Joo Sung Kim (Seoul National University Hospital)H-Index: 8
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Background/Aims: Astragalin (kaempferol-3-O-beta-D-glucoside) is a flavonoid isolated from the leaves of persimmon or Rosa agrestis. Astragalin exhibits various anti-inflammatory properties; however, little is known about its therapeutic potential for inflammatory bowel disease (IBD). This study aims to investigate the anti-inflammatory effect of astragalin via blockade of the nuclear factor kappaB (NF-kappaB) signaling pathway in human colonic epithelial cells and a murine colitis model. Method...
#1Hyuk Yoon (Seoul National University Bundang Hospital)H-Index: 20
#2Deok Hee Lee (Seoul National University Bundang Hospital)H-Index: 52
Last. Jung-Sook Lee (Korea Research Institute of Bioscience and Biotechnology)H-Index: 26
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Background/Aims: South Korean soldiers are exposed to similar environmental factors. In this study, we sought to evaluate the gut microbiome of healthy young male soldiers (HYMS) and to identify the primary factors influencing the microbiome composition. Methods: We prospectively collected stool from 100 HYMS and performed next-generation sequencing of the 16S rRNA genes of fecal bacteria. Clinical data, including data relating to the diet, smoking, drinking, and exercise, were collected. Result...
#1Kei Saito (UTokyo: University of Tokyo)H-Index: 5
#2Yousuke Nakai (UTokyo: University of Tokyo)H-Index: 33
Last. Kazuhiko Koike (UTokyo: University of Tokyo)H-Index: 66
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Background/Aims: ; The aim of this study was to evaluate the safety and efficacy of partially covered self-expandable metallic stents (PCSEMS) in patients undergoing neoadjuvant chemo(radio) therapy (NAC) for pancreatic cancer (PC). Methods: This was a prospective multicenter study to evaluate the safety and efficacy of PCSEMS in patients receiving NAC for resectable and borderline resectable PC. The primary endpoint was the rate of recurrent biliary obstruction (RBO). Results: Twenty-six patien...
Serrated lesions are the precursor lesions of a new model of colorectal carcinogenesis. From a molecular standpoint, the serrated pathway is thought to be responsible for up to 30% of all colorectal cancer cases. The three major processes of this molecular mechanism are alterations in the mitogen-activated protein kinase pathway, production of the CpG island methylation phenotype, and generation of microsatellite instability. Other contributing processes are activation of WNT, alterations in the...
#1Gwang Ha Kim (PNU: Pusan National University)H-Index: 32
Proton pump inhibitors (PPIs) are used worldwide to treat of acid-related disorders such as peptic ulcer and gastroesophageal reflux disease and to prevent gastroduodenal injuries due to nonsteroidal anti-inflammatory drugs. PPIs are the most potent inhibitors of gastric acid secretion currently available, and they are one of the most commonly prescribed classes of drugs because of their high efficacy and low toxicity. However, long-term PPI use causes histopathological changes such as parietal ...
#1Masanori Ito (Hiroshima University)H-Index: 38
#2Shingo Tanaka (Hiroshima University)H-Index: 67
Last. Kazuaki Chayama (Hiroshima University)H-Index: 89
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The prevalence of gastric cancer after eradication (GCAE) is increasing dramatically in Japan. GCAE has characteristic features, and we must understand these features in endoscopic examinations. Differentiated cancer types were frequently found after eradication and included characteristic endoscopic features such as reddish depression (RD). However, benign RD can be difficult to distinguish from gastric cancer because of histological alterations in the surface structures (nonneoplastic epitheli...
#1Keng Hoong Chiam (Lyell McEwin Hospital)
#2Seon Ho Shin (Lyell McEwin Hospital)
Last. Rajvinder Singh (University of Adelaide)H-Index: 26
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Recent advances in endoscopic imaging of the esophagus have revolutionized the diagnostic capability for detecting premalignant changes and early esophageal malignancy. In this article, we review the practical application of narrow-band imaging focusing on diseases of the esophagus, including Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma.
#1Young Eun Ahn (KU: Korea University)
#2Sang Jun Suh (KU: Korea University)H-Index: 11
Last. Seong Hee Kang (Yonsei University)H-Index: 5
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Background/Aims: Sorafenib is the first approved systemic treatment for advanced hepatocellular carcinoma (HCC). However, its clinical utility is limited, especially in Asian countries. Several reports have suggested the survival benefits of hepatic arterial infusion chemotherapy (HAIC) for advanced HCC with main portal vein tumor thrombosis (PVTT). This study aimed to compare the efficacy of sorafenib-based therapy with that of HAIC-based therapy for advanced HCC with main PVTT. Methods: Advanc...
Top fields of study
Diabetes mellitus
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