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G3: Genes, Genomes, Genetics
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#1Elizabeth B. Brown (UC: University of Cincinnati)H-Index: 1
#2John E. Layne (UC: University of Cincinnati)H-Index: 12
Last.Stephanie M. Rollmann (UC: University of Cincinnati)H-Index: 20
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The detection, discrimination, and behavioral responses to chemical cues in the environment can have marked effects on organismal survival and reproduction, eliciting attractive or aversive behavior. To gain insight into mechanisms mediating this hedonic valence, we applied thirty generations of divergent artificial selection for Drosophila melanogaster olfactory behavior. We independently selected for positive and negative behavioral responses to two ecologically relevant chemical compounds: 2,...
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#1Katherine E. Knudsen (NCSU: North Carolina State University)
#2William R. Reid (NCSU: North Carolina State University)H-Index: 1
Last.Maxwell J. Scott (NCSU: North Carolina State University)
view all 8 authors...
Release of insect pests carrying the dominant lethal tetracycline transactivator (tTA) overexpression system has been proposed as a means for population suppression. High levels of the tTA transcription factor are thought to be toxic due to either transcriptional squelching or interference with protein ubiquitination. Here we utilized the Drosophila melanogaster Genetic Reference Panel (DGRP) to examine the influence of genetic variation on the efficacy of a female-specific tTA overexpression sy...
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#1Louis P. Watanabe (UAB: University of Alabama at Birmingham)H-Index: 2
#2Cameron J Gordon (UAB: University of Alabama at Birmingham)
Last.Nicole C. Riddle (UAB: University of Alabama at Birmingham)H-Index: 24
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Exercise is recommended by health professionals across the globe as part of a healthy lifestyle to prevent and/or treat the consequences of obesity. While overall, the health benefits of exercise and an active lifestyle are well understood, very little is known about how genetics impacts an individual9s inclination for and response to exercise. To address this knowledge gap, we investigated the genetic architecture underlying natural variation in activity levels in the model system Drosophila me...
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#1Diego A. Caraballo (UBA: University of Buenos Aires)H-Index: 2
#2Diego Alfredo Caraballo (Facultad de Ciencias Exactas y Naturales)H-Index: 1
Last.María Susana Rossi (UBA: University of Buenos Aires)H-Index: 9
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UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences in their properties. Bayesian phylogenetic inference based on 195 UGGT and UGGT-like protein sequences of an ample spectrum of eukaryotic species showed that uggt genes went through independent duplications...
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#1Yun-ying Zhao (Jiangnan University)
#2Chun-lei Cao (Jiangnan University)
Last.Yu Deng (Jiangnan University)H-Index: 13
view all 7 authors...
Zinc is essential for almost all living organisms, since it serves as a crucial cofactor for transcription factors and enzymes. However, it is toxic to cell growth when present in excess. The present work aims to investigate the toxicity mechanisms induced by zinc stress in yeast cells. To this end, 108 yeast single-gene deletion mutants were identified sensitive to 6 mM ZnCl2 through a genome-wide screen. These genes were predominantly related to the biological processes of vacuolar acidificati...
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#1Emily A. Beck (UO: University of Oregon)H-Index: 1
#2Mark Currey (UO: University of Oregon)H-Index: 11
Last.William A. Cresko (UO: University of Oregon)H-Index: 31
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Selection, via host immunity, is often required to foster beneficial microbial symbionts and suppress deleterious pathogens. In animals, the host immune system is at the center of this relationship. Failed host immune system-microbial interactions can result in a persistent inflammatory response in which the immune system indiscriminately attacks resident microbes, and at times the host cells themselves, leading to diseases such as Ulcerative Colitis, Crohn9s Disease, and Psoriasis. Host genetic...
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#1Peichuan ZhangH-Index: 3
#2Yuying Zhai (UCSF: University of California, San Francisco)
Last.Cynthia KenyonH-Index: 65
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Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are long-lived. To find entry points for small molecules that might extend healthy longevity in humans, we screened ∼100,000 small molecules in a human primary-fibroblast cell line and identified a set that increased oxidative-stress resistance. Some...
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#1Simon A. Schmidt (Australian Wine Research Institute)H-Index: 13
#2Radka Kolouchova (Australian Wine Research Institute)H-Index: 4
Last.Anthony R. Borneman (Australian Wine Research Institute)H-Index: 25
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When a wine yeast is inoculated into grape juice the potential variation in juice composition that confronts it is huge. Assessing the performance characteristics of the many commercially available wine yeasts in the many possible grape juice compositions is a daunting task. To this end we have developed a barcoded Saccharomyces cerevisiae wine yeast collection to facilitate the task of performance assessment that will contribute to a broader understanding of genotype-phenotype relations. Barcod...
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#1Karen A. Schlauch (DRI: Desert Research Institute)
#2Karen Schlauch (DRI: Desert Research Institute)H-Index: 29
Last.Joseph J. Grzymski (DRI: Desert Research Institute)
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The aggregation of Election Health Records (EHR) and personalized genetics leads to powerful discoveries relevant to population health. Here we perform genome-wide association studies (GWAS) and accompanying phenome-wide association studies (PheWAS) to validate phenotype-genotype associations of BMI, and to a greater extent, severe Class 2 obesity, using comprehensive diagnostic and clinical data from the EHR database of our cohort. Three GWASs of 500,000 variants on the Illumina platform of 6,6...
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#1Nikolay P. KandulH-Index: 3
#2Junru LiuH-Index: 2
Last.Omar S. AkbariH-Index: 20
view all 6 authors...
Homing based gene drives (HGD) possess the potential to spread linked cargo genes into natural populations and are poised to revolutionize population control of animals. Given that host encoded genes have been identified that are important for pathogen transmission, targeting these genes using guide RNAs as cargo genes linked to drives may provide a robust method to prevent disease transmission. However, effectiveness of the inclusion of additional guide RNAs that target separate genes has not b...
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