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Alzheimer Disease & Associated Disorders
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#1James C. Borders (Columbia University)
#2Samantha Blanke (UW: University of Wisconsin-Madison)
Last. Nicole Rogus-PuliaH-Index: 8
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Malnutrition and weight loss are highly prevalent in persons with Alzheimer's disease and related dementias. Oral intake is an important interventional target for addressing these nutritional consequences. However, the efficacy of interventions remains poorly understood as prior syntheses have failed to examine the impact of intervention approaches on malnutrition and hypothesized mechanisms of action in persons with dementia. This review aimed to determine the efficacy of mealtime interventions...
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#1Hacer Dogan Varan (Hacettepe University)H-Index: 5
#3Cafer Balci (Hacettepe University)H-Index: 2
Last. David Molloy (UCC: University College Cork)H-Index: 24
view all 15 authors...
BACKGROUND Cutoff values of cognitive screen tests vary according to age and educational levels. OBJECTIVE The objective of this study was to compare the accuracy and determine cutoffs for 3 short cognitive screening instruments: the Mini-Mental State Examination, Montreal Cognitive Assessment (MoCA), and Quick Mild Cognitive Impairment Screen-Turkish version (Qmci-TR), in older adults with low literacy in Turkey. METHODS In all 321 patients, 133 with subjective cognitive complaints (SCC), 88 am...
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IMPORTANCE Female sex is a major risk factor for late-onset Alzheimer disease (AD), and sex hormones have been implicated as a possible protective factor. Neuroimaging studies that evaluated the effects of sex hormones on brain integrity have primarily emphasized neurodegenerative measures rather than amyloid and tau burden. OBJECTIVE We compared cortical amyloid and regional tau positron emission tomography (PET) deposition between cognitively normal males and females. We also compared preclini...
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#1Stephanie R.A. Moulin Mares (UFES: Universidade Federal do Espírito Santo)
#2Jaqueline S. Groner (UFES: Universidade Federal do Espírito Santo)
Last. Weverton Machado Luchi (UFES: Universidade Federal do Espírito Santo)H-Index: 2
view all 6 authors...
Takotsubo cardiomyopathy (TC) is an acute cardiac dysfunction, clinically similar to myocardial ischemia. The physiopathology of the syndrome seems to be related to excessive sympathetic activity that is triggered by physical or emotional stress factors. We report the case of an 83-year-old woman with advanced Alzheimer disease who had recently used nortriptyline and sertraline and was admitted with chest pain. An electrocardiogram showed ST-elevation, and markers of myocardial necrosis were sli...
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INTRODUCTION Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderat...
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Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ1-42) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ1-42 and amyloid PET, several studies also reported discrepancies between these 2 Aβ biomarkers. We conducted a comparison of CSF Aβ1-42 level, amyloid PET, and autopsy f...
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BACKGROUND Chronic cerebrovascular pathology accelerates the incidence of poststroke dementia (PSD). Whether the risk of PSD varies according to different types of chronic cerebrovascular pathology remains unclear. OBJECTIVES We investigated whether PSD is associated with a unique pattern of interactions between chronic cerebrovascular pathologies and acute stroke lesions. MATERIALS AND METHOD In this case-control study of acute mild stroke patients (n=185), cases included patients who developed...
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#1Parveen K. Garg (SC: University of Southern California)H-Index: 8
#2Annabel X. Tan (Stanford University)
Last. Kenneth J. Mukamal (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 61
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INTRODUCTION Brachial flow-mediated dilation (FMD) is a physiologic measure of endothelial function. We determined the prospective association of brachial FMD with incident dementia among older adults. METHODS We included 2777 Cardiovascular Health Study participants who underwent brachial FMD measurement. Incident dementia was ascertained by medication use, International Classification of Diseases-9 codes, requirement for a proxy, and death certificates and calibrated to gold-standard assessmen...
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#1Chol Shin (KU: Korea University)H-Index: 41
#2Regina E.Y. Kim (KU: Korea University)
Last. Robert D. ABBm (KU: Korea University)H-Index: 78
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BACKGROUND While obesity is linked with brain atrophy and dementia incidence, associations with regional adiposity are uncertain. Our goal was to determine whether cerebral gray matter volume is related to neck circumference (NC), a measure of regional adiposity having unique relationships with metabolic disorders and cardiovascular disease. METHODS Magnetic resonance imaging and NC were cross-sectionally assessed from 2011 to 2014 in a population-based sample of 2916 men and women in the Korean...
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#1Bonnie C. SachsH-Index: 14
#2Kyle SteenlandH-Index: 67
Last. Felicia C. Goldstein (Emory University)H-Index: 31
view all 10 authors...
BACKGROUND Norms for the Uniform Data Set Version 3 Neuropsychological Battery are available for cognitively normal individuals based on age, education, and sex; however, these norms do not include race. We provide expanded norms for African Americans and whites. METHODS Data from 32 Alzheimer's Disease Centers (ADCs) and ADC affiliated cohorts with global Clinical Dementia Rating Scale (CDR) Dementia Staging Instrument scores of 0 were included. Descriptive statistics for each test were calcula...
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Top fields of study
Psychiatry
Pathology
Psychology
Dementia
Alzheimer's disease