Papers 14713
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#1Susan E. OzanneH-Index: 64
This is an invited review but MRC and the Brtish Heart Foundation are acknowledged as our funders
#1Sarah-Naomi James (UCL: University College London)H-Index: 4
#2Anson Wong (UCL: University College London)H-Index: 56
Last.Marcus Richards (UCL: University College London)H-Index: 49
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Aims/hypothesis Type 2 diabetes, hyperglycaemia and insulin resistance are associated with cognitive impairment and dementia, but causal inference studies using Mendelian randomisation do not confirm this. We hypothesised that early-life cognition and social/educational advantage may confound the relationship.
#1Maria E. Craig (UNSW: University of New South Wales)H-Index: 42
#2Ki Wook Kim (UNSW: University of New South Wales)H-Index: 5
Last.William D. Rawlinson (UNSW: University of New South Wales)H-Index: 57
view all 7 authors...
The incidence of type 1 diabetes has increased since the mid-twentieth century at a rate that is too rapid to be attributed to genetic predisposition alone. While the disease can occur at any age, mounting evidence from longitudinal cohort studies of at-risk children indicate that type 1 diabetes associated autoantibodies can be present from the first year of life, and that those who develop type 1 diabetes at a young age have a more aggressive form of the disease. This corroborates the hypothes...
#1Patrick Timpel (TUD: Dresden University of Technology)H-Index: 2
#2Lorenz Harst (TUD: Dresden University of Technology)H-Index: 1
Last.Peter Schwarz (TUD: Dresden University of Technology)H-Index: 36
view all 5 authors...
Health systems and governments are increasingly required to implement measures that target at-risk populations to prevent noncommunicable diseases. In this review we lay out what governments should be doing to prevent diabetes throughout the life course. The following four target groups were used to structure the specific recommendations: (1) pregnant women and young families, (2) children and adolescents, (3) working age population, and (4) the elderly. The evidence to date supports the effecti...
Aims/hypothesis Previous studies have demonstrated a relationship between cognitive impairment and hypoglycaemia (<3 mmol/l). This study hypothesised that non-severe insulin-induced hypoglycaemia reduces cognitive function in individuals with type 2 diabetes.
#1Zien Zhou (The George Institute for Global Health)
#2Meg Jardine (The George Institute for Global Health)H-Index: 32
Last.Roger Simpson (Janssen Pharmaceutica)
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Aims/hypothesis An increased risk of fracture with canagliflozin vs placebo was reported from the CANagliflozin cardioVascular Assessment Study (CANVAS) Program, with heterogeneity of findings identified between the two trials that comprise the CANVAS Program, CANVAS and CANVAS-R. The objective of these analyses was to identify reasons for the possibly different effects on fracture observed between CANVAS and CANVAS-R.
#1Amy G. Huebschmann (University of Colorado Denver)H-Index: 11
#2Rachel R. Huxley (La Trobe University)H-Index: 59
Last.Jane E.B. Reusch (University of Colorado Denver)H-Index: 44
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By 2017 estimates, diabetes mellitus affects 425 million people globally; approximately 90–95% of these have type 2 diabetes. This narrative review highlights two domains of sex differences related to the burden of type 2 diabetes across the life span: sex differences in the prevalence and incidence of type 2 diabetes, and sex differences in the cardiovascular burden conferred by type 2 diabetes. In the presence of type 2 diabetes, the difference in the absolute rates of cardiovascular disease (...
#1Chelsea R. Hutch (UM: University of Michigan)H-Index: 7
#2Karen J. Roelofs (UM: University of Michigan)H-Index: 16
Last.Darleen A. Sandoval (UM: University of Michigan)H-Index: 33
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Aims/hypothesis Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two peptides that function to promote insulin secretion. Dipeptidyl peptidase-4 (DPP-4) inhibitors increase the bioavailability of both GLP-1 and GIP but the dogma continues to be that it is the increase in GLP-1 that contributes to the improved glucose homeostasis. We have previously demonstrated that pancreatic rather than intestinal GLP-1 is necessary for improvements in glucose homeosta...
#1Sherita Hill Golden (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 49
Last.William C. Knowler (NIH: National Institutes of Health)H-Index: 91
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Type 2 diabetes is a common disease worldwide, but its prevalence varies widely by geographical region and by race/ethnicity. This review summarises differences in the frequencies of type 2 diabetes according to race, ethnicity, socioeconomic position, area of residence and environmental toxins. Type 2 diabetes susceptibility often begins early in life, starting with genetic susceptibility at conception and continuing in later life, via in utero, childhood and adult exposures. Early-life factors...