Papers 10000
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#1Mingjuan He (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Yixiang Li (Emory University)H-Index: 4
Last. Liming Zhang (Southern Medical University)
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AIMS/HYPOTHESIS Myeloid-derived growth factor (MYDGF), mainly secreted by bone marrow-derived cells, has been known to promote glucagon-like peptide-1 production and improve glucose/lipid metabolism in mouse models of diabetes, but little is known about the functions of MYDGF in diabetic kidney disease (DKD). Here, we investigated whether MYDGF can prevent the progression of DKD. METHODS In vivo experiments, both loss- and gain-of-function strategies were used to evaluate the effect of MYDGF on ...
#1Drazenka Pongrac Barlovic (UH: University of Helsinki)
#2Valma HarjutsaloH-Index: 22
Last. Per-Henrik GroopH-Index: 62
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Aims/hypothesis Lipid abnormalities are associated with diabetic kidney disease and CHD, although their exact role has not yet been fully explained. Sphingomyelin, the predominant sphingolipid in humans, is crucial for intact glomerular and endothelial function. Therefore, the objective of our study was to investigate whether sphingomyelin impacts kidney disease and CHD progression in individuals with type 1 diabetes. Methods Individuals (n = 1087) from the Finnish Diabetic Nephropathy (FinnDian...
#1Wendy K. Chung (Columbia University)H-Index: 5
#2Karel Erion (American Diabetes Association)
Last. Ewan R. Pearson (Dund.: University of Dundee)H-Index: 44
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The convergence of advances in medical science, human biology, data science and technology has enabled the generation of new insights into the phenotype known as ‘diabetes’. Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence and how best practice in treatment varies between populations. In parallel, focus has been placed on the development of tools for the application of precision med...
#1Akira Asai (Nippon Medical School)H-Index: 7
#2Mototsugu Nagao (Nippon Medical School)H-Index: 10
Last. Shinichi Oikawa (Nippon Medical School)H-Index: 43
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Obesity caused by overeating plays a pivotal role in the development of type 2 diabetes. However, it remains poorly understood how individual meal size differences are determined before the development of obesity. Here, we investigated the underlying mechanisms in determining spontaneous food intake in newly established Oikawa–Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mice. Food intake and metabolic phenotypes of ON-DP and ON-DR mice under high-fat-diet feeding were compared fr...
#1Yu Liu (NU: Northwestern University)
#3Alan Kuang (NU: Northwestern University)H-Index: 4
Last. Boyd E. Metzger (NU: Northwestern University)H-Index: 61
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AIMS/HYPOTHESIS Our study aimed to integrate maternal metabolic and genetic data related to insulin sensitivity during pregnancy to provide novel insights into mechanisms underlying pregnancy-induced insulin resistance. METHODS Fasting and 1 h serum samples were collected from women in the Hyperglycemia and Adverse Pregnancy Outcome study who underwent an OGTT at ∼28 weeks' gestation. We obtained targeted and non-targeted metabolomics and genome-wide association data from 1600 and 4528 mothers, ...
#1Rafael Simó Canonge (Hebron University)H-Index: 51
#2Coen D.A. Stehouwer (Maastricht University Medical Centre)H-Index: 110
Last. Angelo Avogaro (UNIPD: University of Padua)H-Index: 70
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#1Jeffrey P. Krischer (USF: University of South Florida)H-Index: 74
#2David Cuthbertson (USF: University of South Florida)H-Index: 34
Last. Suvi M. VirtanenH-Index: 53
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AIMS/HYPOTHESIS This paper presents the relationship between islet autoantibodies, precursors of type 1 diabetes, and the development of persistent asthma, allergic rhinitis and atopic eczema. METHODS A total of 2159 newborns who had a first-degree relative with type 1 diabetes and selected HLA genotypes were followed until the youngest participant reached 10 years of age. Islet cell antibodies (ICA) were detected using indirect immunofluorescence. Autoantibodies to insulin (IAA), GAD (GADA), th...
#1Christian Stern (MLU: Martin Luther University of Halle-Wittenberg)
#2Barbara Schreier (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 7
Last. Michael Gekle (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 44
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AIMS/HYPOTHESIS Obesity causes type 2 diabetes leading to vascular dysfunction and finally renal end-organ damage. Vascular smooth muscle (VSM) EGF receptor (EGFR) modulates vascular wall homeostasis in part via serum response factor (SRF), a major regulator of VSM differentiation and a sensor for glucose. We investigated the role of VSM-EGFR during obesity-induced renovascular dysfunction, as well as EGFR-hyperglycaemia crosstalk. METHODS The role of VSM-EGFR during high-fat diet (HFD)-induced ...
#1Michael Larsen (NTNU: Norwegian University of Science and Technology)H-Index: 10
#1Michael Larsen (NTNU: Norwegian University of Science and Technology)H-Index: 41
Last. Bente Mertz Nørgård (OUH: Odense University Hospital)H-Index: 27
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AIMS/HYPOTHESIS Type 1 and type 2 diabetes are among the most prevalent chronic diseases in women in the fertile years and women with diabetes may experience several reproductive issues. We aimed to examine the chance of biochemical pregnancy, clinical pregnancy and live birth after assisted reproductive technology (ART) treatment in women with type 1 and type 2 diabetes and whether obesity per se influenced the results. METHODS This nationwide register-based cohort study is based on the Danish ...
#1Susanna C. Larsson (Uppsala University)H-Index: 62
#2Karl Michaëlsson (Uppsala University)H-Index: 63
Last. Stephen Burgess (University of Cambridge)H-Index: 47
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AIMS/HYPOTHESIS Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between genetically predicted serum IGF-1 levels and cardiometabolic diseases. METHODS Serum IGF-1 levels were predicted using 416 SNPs associated with IGF-1 levels among 358,072 individuals in UK B...
Top fields of study
Diabetes mellitus