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Diabetologia
IF
7.11
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Papers 14954
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#1Sophie Rose Sayers ('KCL': King's College London)H-Index: 2
#2Sophie SayersH-Index: 5
Last.Paul CatonH-Index: 14
view all 16 authors...
Aims/hypothesis Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance in mouse models of diabetes. Despite this, the effects of eNAMPT on functional beta cell mass are poorly elucidated, with some studies having separately reported beta cell-protectiv...
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#1C Niersmann (HHU: University of Düsseldorf)H-Index: 2
#2Maren Carstensen-Kirberg (HHU: University of Düsseldorf)H-Index: 10
Last.Ben Schoettker (DKFZ: German Cancer Research Center)H-Index: 43
view all 8 authors...
Aims/hypothesis Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin concentrations are associated with increased risk of cardiovascular events in people with established diabetes. Therefore, the present study investigated the association between s...
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#1Thaddeus Waters (Loyola University Medical Center)H-Index: 14
#2Shin Y. Kim (CDC: Centers for Disease Control and Prevention)H-Index: 21
Last.Patrick M. Catalano (Case Western Reserve University)H-Index: 60
view all 14 authors...
Aims/hypothesis This study aimed to determine, in women with gestational diabetes (GDM), the changes in insulin sensitivity (Matsuda Insulin Sensitivity Index; ISOGTT), insulin response and disposition index (DI) from late pregnancy (34–37 weeks gestation, T1), to early postpartum (1–5 days, T2) and late postpartum (6–12 weeks, T3). A secondary aim was to correlate the longitudinal changes in maternal lipids, adipokines, cytokines and weight in relation to the changes in ISOGTT, insulin response...
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#1Goo Jun (University of Texas Health Science Center at Houston)H-Index: 25
#2David Aguilar (University of Texas Health Science Center at Houston)H-Index: 8
Last.Craig L. Hanis (University of Texas Health Science Center at Houston)H-Index: 50
view all 5 authors...
Aims/hypothesis To understand the complex metabolic changes that occur long before the diagnosis of type 2 diabetes, we investigated differences in metabolomic profiles in plasma between prediabetic and normoglycaemic individuals for subtypes of prediabetes defined by fasting glucose, 2 h glucose and HbA1c measures.
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#1Bryan M. Williams (Lancaster University)H-Index: 7
#2Davide Borroni (RLUH: Royal Liverpool University Hospital)H-Index: 3
Last.Yalin Zheng (University of Liverpool)H-Index: 19
view all 16 authors...
Aims/hypothesis Corneal confocal microscopy is a rapid non-invasive ophthalmic imaging technique that identifies peripheral and central neurodegenerative disease. Quantification of corneal sub-basal nerve plexus morphology, however, requires either time-consuming manual annotation or a less-sensitive automated image analysis approach. We aimed to develop and validate an artificial intelligence-based, deep learning algorithm for the quantification of nerve fibre properties relevant to the diagnos...
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#2Iris Erlund (National Institute for Health and Welfare)H-Index: 20
Last.Suvi M. VirtanenH-Index: 14
view all 17 authors...
Aims/hypothesis We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes.
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#1Lingling Ding (UM: Maastricht University)
#2Gijs H. Goossens (UM: Maastricht University)H-Index: 31
Last.Ronit Shiri-Sverdlov (UM: Maastricht University)H-Index: 24
view all 6 authors...
Aims/hypothesis Insulin resistance in skeletal muscle and liver plays a major role in the pathophysiology of type 2 diabetes. The hyperinsulinaemic–euglycaemic clamp is considered the gold standard for assessing peripheral and hepatic insulin sensitivity, yet it is a costly and labour-intensive procedure. Therefore, easy-to-measure, cost-effective approaches to determine insulin sensitivity are needed to enable organ-specific interventions. Recently, evidence emerged that plasma cathepsin D (CTS...
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#1Helga EllingsgaardH-Index: 13
#2Eleonora SeeligH-Index: 5
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 14 authors...
Aims/hypothesis IL-6 is a cytokine with various effects on metabolism. In mice, IL-6 improved beta cell function and glucose homeostasis via upregulation of glucagon-like peptide 1 (GLP-1), and IL-6 release from muscle during exercise potentiated this beneficial increase in GLP-1. This study aimed to identify whether exercise-induced IL-6 has a similar effect in humans.
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#1R. David Leslie (QMUL: Queen Mary University of London)H-Index: 12
#2Tanwi Vartak (QMUL: Queen Mary University of London)
Physiological plasticity enables homeostasis to be maintained in biological systems, but when such allostasis fails, then disease can develop. In a new population-based study by Rolandsson et al ( https://doi.org/10.1007/s00125-019-05016-3), autoimmunity, defined by an immunogenotype, predicted adult-onset non-insulin requiring diabetes. Type 1 diabetes is no longer viewed as a disease confined to children, with a significant proportion, maybe the majority, presenting in adulthood. Such cases ma...
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#1Olov Rolandsson (Umeå University)H-Index: 46
#2Christiane S. Hampe (UW: University of Washington)H-Index: 27
Last.Nicholas J. Wareham (University of Cambridge)H-Index: 169
view all 29 authors...
Aims/hypothesis Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic ...
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Top fields of study
Endocrinology
Insulin
Diabetes mellitus
Medicine
Biology