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Sophia Havaki
National and Kapodistrian University of Athens
33Publications
8H-index
320Citations
Publications 33
Newest
#1Katerina Gioti (RMIT: RMIT University)
#2Anastasia Papachristodoulou (RMIT: RMIT University)
Last.Roxane Tenta (RMIT: RMIT University)H-Index: 14
view all 10 authors...
Silymarin-enriched extract (SEE) is obtained from Silybum marianum (Asteraceae). Doxorubicin (DXR) is a widely used chemotherapeutical yet with severe side effects. The goal of the present study was to assess the pharmacologic effect of SEE and its bioactive components silibinin and silychristine when administrated alone or in combination with DXR in the human prostate cancer cells (PC-3). PC-3 cells were treated with SEE, silibinin (silybins A and B), silychristine, alone, and in combination wi...
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#1Panagiotis Vasileiou (UoA: National and Kapodistrian University of Athens)H-Index: 10
#2Konstantinos Evangelou (UoA: National and Kapodistrian University of Athens)H-Index: 18
Last.Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
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Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a co...
1 CitationsSource
#1Sophia V. Rizou (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 2
Last.Vassilis G. GorgoulisH-Index: 47
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4 CitationsSource
#1Sophia V. Rizou (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 18
Last.Vassilis G. GorgoulisH-Index: 47
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Source
#1Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
#2Vassiliki Vlachou (UoA: National and Kapodistrian University of Athens)H-Index: 2
Last.Vassilis G. GorgoulisH-Index: 47
view all 12 authors...
Autophagy is a catabolic process that preserves cellular homeostasis. Its exact role during carcinogenesis is not completely defined. Specifically in head and neck cancer, such information from clinical settings that comprise the whole spectrum of human carcinogenesis is very limited. Towards this direction, we examined the in situ status of the autophagy-related factors, Beclin-1, microtubule-associated protein 1 light chain 3, member B (LC3B) and sequestosome 1/p62 (p62) in clinical material c...
2 CitationsSource
#1Aristides G. Eliopoulos (FORTH: Foundation for Research & Technology – Hellas)H-Index: 45
#2Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
Last.Vassilis G. Gorgoulis (University of Manchester)H-Index: 10
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Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for several functional outcomes of DDR signaling, including repair of DNA lesions, senescence, cell death, and cytokine secretion. Uncovering the mechanisms by which autophagy and DDR are intertwined provide...
41 CitationsSource
We report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as a reddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrine adenocarcinoma with pagetoid phenomenon. The tumor recurred after four months and then excision biopsy showed tumor with pagetoid phenomenon which reached all the surgical margins. Three months later an ulcerated nodule in the scrotum and greatly enlarged ...
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#1Ioannis S. Pateras (UoA: National and Kapodistrian University of Athens)H-Index: 19
#2Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
Last.Vassilis G. GorgoulisH-Index: 47
view all 8 authors...
Abstract The characteristic feature of healthy living organisms is the preservation of homeostasis. Compelling evidence highlight that the DNA damage response and repair (DDR/R) and immune response (ImmR) signaling networks work together favoring the harmonized function of (multi)cellular organisms. DNA and RNA viruses activate the DDR/R machinery in the host cells both directly and indirectly. Activation of DDR/R in turn favors the immunogenicity of the incipient cell. Hence, stimulation of DDR...
74 CitationsSource
#1Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
#2AthanassiosKotsinas (UoA: National and Kapodistrian University of Athens)H-Index: 27
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
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Abstract Ionizing radiation (IR) has been described as a double-edged sword, since it is used for diagnostic and therapeutic medical applications, and at the same time it is a well known human mutagen and carcinogen, causing wide-ranging chromosomal aberrations. It is nowadays accepted that the detrimental effects of IR are not restricted only in the irradiated cells, but also to non-irradiated bystander or even distant cells manifesting various biological effects. This review presents the role ...
49 CitationsSource
#1Margarita Chrysanthou Piterou (UoA: National and Kapodistrian University of Athens)
Last.Marietta Issidorides Radovitch (UoA: National and Kapodistrian University of Athens)
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