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Valeria Castelletto
University of Reading
Small-angle X-ray scatteringCopolymerOrganic chemistryChemistryPeptide
208Publications
41H-index
5,475Citations
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Publications 208
Newest
#1Abshar Hasan (University of Strathclyde)H-Index: 12
#2Varun Saxena (University of Strathclyde)
Last. King Hang Aaron Lau (University of Strathclyde)H-Index: 20
view all 10 authors...
Poly(N-substituted glycine) “peptoids” are an interesting class of peptidomimics that can resist proteolysis and mimic naturally found antimicrobial peptides (AMPs), which exhibit wide spectrum activity against bacteria. This work investigates the possibility of modifying peptoid AMP mimics (AMPMs) with aliphatic lipid “tails” to generate “lipopeptoids” that can assemble into micellar nanostructures, and evaluates their antimicrobial activities. Two families of AMPMs with different distributions...
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#1Elham RadvarH-Index: 3
#2Yejiao ShiH-Index: 4
Last. Helena S. AzevedoH-Index: 27
view all 10 authors...
A molecular design approach to fabricate nanofibrous membranes by self-assembly of aromatic cationic peptides with hyaluronic acid (HA) and nanofiber alignment under a magnetic field is reported. Peptides are designed to contain a block composed of four phenylalanine residues at the C-terminus, to drive their self-assembly by hydrophobic association and aromatic stacking, and a positively charged domain of lysine residues for electrostatic interaction with HA. These two blocks are connected by a...
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#1Juliane N. B. D. Pelin (University of Reading)H-Index: 2
#2Charlotte J. C. Edwards-Gayle (University of Reading)H-Index: 3
Last. Wendel A. Alves (UFABC: Universidade Federal do ABC)H-Index: 19
view all 7 authors...
Morphological, spectroscopic and scattering studies of the self-assembly and aggregation process of hybrids containing gold nanoparticles (AuNPs) and the amyloid peptides [RF]4 and P[RF]4 (where R = arginine; F = phenylalanine; P = proline) in aqueous solution were performed. Two methodologies were tested for the AuNP nucleation, using sodium borohydride (NaBH4) or epigallocatechin gallate (EGCG) as a reducing agent. This led to remarkable distinct modes of assembly, AuNP decorated fibrils with ...
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#1Lucas R. MelloH-Index: 1
#2Ian W. HamleyH-Index: 63
Last. Emerson R. SilvaH-Index: 11
view all 9 authors...
Penetratin is a short Trojan peptide that attracts great interest in biomedical research for its capacity to translocate biological membranes. Herein, we study in detail both self-assembly and intracellular delivery of DNA by the heptamer KIWFQNR, a truncated peptide derived from Penetratin. This shortened sequence possesses a unique design with bolaamphiphilic characteristics that preserves the longest noncationic amino acid portion found in Penetratin. These features convey amphipathicity to a...
1 CitationsSource
#1Valeria Castelletto (University of Reading)H-Index: 41
#2Jani Seitsonen (Aalto University)H-Index: 18
Last. King Hang Aaron Lau (University of Strathclyde)H-Index: 20
view all 9 authors...
Peptoids are biofunctional N-substituted glycine peptidomimics. Their self-assembly is of fundamental interest because they demonstrate alternatives to conventional peptide structures based on back...
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#1Juliane N. B. D. Pelin (University of Reading)
Last. Ian W. HamleyH-Index: 63
view all 8 authors...
The self-assembly of the amphiphilic lipopeptide PAEPKI-C16 (P = proline, A = alanine, E = glutamic acid, K = lysine, I = isoleucine, C16 = hexadecyl) was investigated using a combination of spectr...
1 CitationsSource
#1Juliane N. B. D. Pelin (University of Reading)
Last. Wendel A. AlvesH-Index: 19
view all 7 authors...
Morphological, spectroscopic and scattering studies of the self-assembly and aggregation process of mixtures of [RF]4 and P[RF]4 peptides (where: R = arginine; F = phenylalanine; P = proline), in solution and as hydrogels, were performed to obtain information about polymorphism. CD data confirmed a β-sheet secondary structure conformation for the solutions and TEM images revealed nanofibers with diameters of ~ 10 nm and micrometer lengths. SAXS curves were fitted using a mass fractal-component a...
1 CitationsSource
#2Glyn BarrettH-Index: 3
Last. Ian W. HamleyH-Index: 63
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The self-assembly behaviour and antimicrobial activity of two new designed amphiphilic peptides, R3F3 and R4F4, containing short hydrophobic phenylalanine (F) cationic arginine (R) sequences are investigated. The conformation of the peptides was examined using circular dichroism and FTIR spectroscopy, which show that they have a disordered secondary structure. Concentration-dependent fluorescence assays show the presence of a critical aggregation concentration (cac) for each peptide. Above the c...
1 CitationsSource
#1Valeria Castelletto (University of Reading)H-Index: 41
#2Charlotte J. C. Edwards-Gayle (University of Reading)H-Index: 3
Last. Emerson R. Silva (UNIFESP: Federal University of São Paulo)H-Index: 11
view all 8 authors...
Three model arginine-rich tripeptides RXR (X= W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.
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#1Valeria Castelletto (University of Reading)H-Index: 41
#2Charlotte J. C. Edwards-Gayle (University of Reading)H-Index: 3
Last. Janne Ruokolainen (Aalto University)H-Index: 48
view all 6 authors...
A novel lipopeptide C16KTTβAH was designed that incorporates the KTT tripeptide sequence from “Matrixyl” lipopeptides along with the bioactive βAH (β-alanine-histidine) carnosine dipeptide motif, attached to a C16 hexadecyl lipid chain. We show that this peptide amphiphile self-assembles above a critical aggregation concentration into β-sheet nanotape structures in water, phosphate-buffered saline (PBS), and cell culture media. Nanotape bundle structures were imaged in PBS, the bundling resultin...
3 CitationsSource
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