Michael Stumvoll
Leipzig University
EndocrinologyInsulinDiabetes mellitusMedicineBiology
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Publications 740
#1Frauke Beyer (MPG: Max Planck Society)H-Index: 6
#2Rui Zhang (MPG: Max Planck Society)H-Index: 82
Last. Anja Veronica Witte (MPG: Max Planck Society)H-Index: 4
view all 8 authors...
Background: Obesity is of complex origin, involving genetic and neurobehavioral factors. Most consistently, polymorphisms in the fat-and-obesity associated gene (FTO) may increase the risk for developing obesity by modulating dopaminergic signaling in the brain. Dopamine-dependent behaviors, such as reward processing, are crucial for eating behavior and are altered in obesity. Yet, few studies have investigated the association of obesity, related genetic variants and structural connectivity of t...
#1Sara Vieira-Silva (Katholieke Universiteit Leuven)H-Index: 21
#3Gwen Falony (Katholieke Universiteit Leuven)H-Index: 25
Last. Mireia Valles-Colomer (Katholieke Universiteit Leuven)H-Index: 6
view all 46 authors...
Microbiome community typing analyses have recently identified the Bacteroides2 (Bact2) enterotype, an intestinal microbiota configuration that is associated with systemic inflammation and has a high prevalence in loose stools in humans1,2. Bact2 is characterized by a high proportion of Bacteroides, a low proportion of Faecalibacterium and low microbial cell densities1,2, and its prevalence varies from 13% in a general population cohort to as high as 78% in patients with inflammatory bowel diseas...
1 CitationsSource
#1Lucas Massier (Leipzig University)
#2Rima Chakaroun (Leipzig University)H-Index: 4
Last. Michael Stumvoll (Leipzig University)H-Index: 92
view all 15 authors...
OBJECTIVE: Bacterial translocation to various organs including human adipose tissue (AT) due to increased intestinal permeability remains poorly understood. We hypothesised that: (1) bacterial presence is highly tissue specific and (2) related in composition and quantity to immune inflammatory and metabolic burden. DESIGN: We quantified and sequenced the bacterial 16S rRNA gene in blood and AT samples (omental, mesenteric and subcutaneous) of 75 subjects with obesity with or without type 2 diabe...
#1Thomas Ebert (KI: Karolinska Institutet)H-Index: 17
#2Claudia Gebhardt (Leipzig University)H-Index: 4
Last. Anke Tönjes (Leipzig University)H-Index: 56
view all 9 authors...
Abstract Aims Adipose tissue-secreted proteins, i.e. adipocytokines, have been identified as potential mediators linking fat mass and adipose tissue dysfunction with impaired glucose homeostasis, alterations in the inflammatory status, and risk of diabetes. The aim of this study was to determine whether seven circulating adipocytokines are associated with gestational diabetes mellitus (GDM) or are altered by metabolic and weight changes during pregnancy itself. Methods A panel of seven adipocyto...
#1Katrin Esefeld (TUM: Technische Universität München)H-Index: 6
#2Verena Heinicke (TUM: Technische Universität München)
Last. Martin Halle (TUM: Technische Universität München)H-Index: 38
view all 8 authors...
#1Jana Breitfeld (Leipzig University)H-Index: 10
#2Stephanie Kehr (Leipzig University)H-Index: 10
Last. Peter Kovacs (Leipzig University)H-Index: 66
view all 8 authors...
Subcutaneous (sc) and visceral (vis) adipose tissue (AT) contribute to the variability in pathophysiological consequences of obesity and adverse fat distribution. To gain insights into the molecular mechanisms distinguishing vis and sc fat, we compared the transcriptome during differentiation of immortalized adipocytes from murine epididymal (epi) and inguinal (ing) AT. RNA was extracted on different days of adipogenesis (-2, 0, 2, 4, 6, 8) and analyzed using Clariom™ D mouse assays (Affymetrix)...
#1Thomas Jacobi (Leipzig University)
#2Lucas Massier (Leipzig University)
Last. Joachim Thiery (Leipzig University)H-Index: 53
view all 16 authors...
CONTEXT: Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes. OBJECTIVES AND DESIGN: Three cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N =...
#1Nora Klöting (Leipzig University)H-Index: 41
#2Matthias Kern (Leipzig University)H-Index: 18
Last. Matthias Blüher (Leipzig University)H-Index: 79
view all 5 authors...
OBJECTIVES: We tested the hypothesis that a genetic deletion (Del) variant in the REPIN1 gene is associated with the severity of nonalcoholic fatty liver disease (NAFLD) in humans. METHODS: Sixty-three donors of liver biopsies from individuals with obesity and different degrees of NAFLD and fibrosis were screened for a Del REPIN1 gene variant and liver REPIN1 mRNA expression. RESULTS: In 8 homozygous Del carriers, we found significantly lower NAFLD activity and fibrosis scores compared with 55 w...
#1Jörn F. Ziegler (Humboldt University of Berlin)
#2Chotima Böttcher (Humboldt University of Berlin)H-Index: 1
Last. Carl Weidinger (Humboldt University of Berlin)H-Index: 1
view all 25 authors...
Leptin has been shown to modulate intestinal inflammation in mice. However, clinical evidence regarding its immune-stimulatory potential in human Crohn’s disease remains sparse. We here describe a patient with the unique combination of acquired generalized lipodystrophy and Crohn’s disease (AGLCD) featuring a lack of adipose tissue, leptin deficiency and intestinal inflammation. Using mass and flow cytometry, immunohistochemistry and functional metabolic analyses, the AGLCD patient was compared ...
1 CitationsSource