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JanosPapp
165Publications
25H-index
2,056Citations
Publications 169
Newest
#1Laura Fachal (University of Cambridge)H-Index: 20
#2Hugues Aschard (Harvard University)H-Index: 21
Last.Alison M. Dunning (University of Cambridge)H-Index: 81
view all 552 authors...
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched gen...
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#1Haoyu Zhang (Johns Hopkins University)H-Index: 3
#2Haoyu Zhang (Johns Hopkins University)H-Index: 2
Last.Nilanjan Chatterjee (Johns Hopkins University)H-Index: 16
view all 276 authors...
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fac...
2 CitationsSource
#1Valentina Silvestri (Sapienza University of Rome)H-Index: 10
#2Daniel Barrowdale (University of Cambridge)H-Index: 24
Last.Laura Ottini (Sapienza University of Rome)H-Index: 34
view all 146 authors...
Background BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs).
32 CitationsSource
#1Lorant GoncziH-Index: 6
#2Zsuzsanna KurtiH-Index: 10
Last.Peter L. LakatosH-Index: 58
view all 13 authors...
Absztrakt: Bevezetes es celkitűzes: A Semmelweis Egyetem I. Belgyogyaszati Klinikajanak endoszkopos laboratoriumaban vizsgaltak a felső es also endoszkopiak indikacioit, a diagnozisok megoszlasat indikaciok szerint, valamint a kolonoszkopiak minősegi mutatoit. Modszer: 2010. januar 1. es 2011. december 31. kozott 2987 beteg felső es also endoszkopos vizsgalatanak adatait elemeztek (ferfi/nő: 1361/1626, atlageletkor: 60,7 ev, SD: 16,7 ev) a fekvő- es jarobeteg-megjelenesek riportjaibol. Eredmenye...
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#1Tibor VaszkóH-Index: 1
#2JanosPappH-Index: 25
Last.Edith OlahH-Index: 36
view all 6 authors...
Due to its palindromic setup, AZFc (Azoospermia Factor c) region of chromosome Y is one of the most unstable regions of the human genome. It contains eight gene families expressed mainly in the testes. Several types of rearrangement resulting in changes in the cumulative copy number of the gene families were reported to be associated with diseases such as male infertility and testicular germ cell tumors. The best studied AZFc rearrangement is gr/gr deletion. Its carriers show widespread phenotyp...
1 CitationsSource
#1Anikó BozsikH-Index: 2
#2JanosPappH-Index: 25
Last.Éva OláhH-Index: 19
view all 7 authors...
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#2Anikó BozsikH-Index: 2
Last.Éva OláhH-Index: 19
view all 5 authors...
Source
#1Lorant GoncziH-Index: 6
#2Zsuzsanna KurtiH-Index: 10
Last.PeterLaszloLakatosH-Index: 8
view all 13 authors...
Absztrakt: Bevezetes es celkitűzes: A Semmelweis Egyetem I. Belgyogyaszati Klinikajanak endoszkopos laboratoriumaban vizsgaltak a felső es also endoszkopiak indikacioit, a diagnozisok megoszlasat indikaciok szerint, valamint a kolonoszkopiak minősegi mutatoit. Modszer: 2010. januar 1. es 2011. december 31. kozott 2987 beteg felső es also endoszkopos vizsgalatanak adatait elemeztek (ferfi/nő: 1361/1626, atlageletkor: 60,7 ev, SD: 16,7 ev) a fekvő- es jarobeteg-megjelenesek riportjaibol. Eredmenye...
#1JanosPappH-Index: 25
#2Marietta Eva Kovacs (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
Last.Edith OlahH-Index: 36
view all 7 authors...
Familial adenomatous polyposis (FAP) is a colorectal cancer predisposition syndrome with considerable genetic and phenotypic heterogeneity, defined by the development of multiple adenomas throughout the colorectum. FAP is caused either by monoallelic mutations in the adenomatous polyposis coli gene APC, or by biallelic germline mutations of MUTYH, this latter usually presenting with milder phenotype. The aim of the present study was to characterize the genotype and phenotype of Hungarian FAP pat...
12 CitationsSource
#1Timothy R. Rebbeck (UPenn: University of Pennsylvania)H-Index: 80
#2Nandita Mitra (UPenn: University of Pennsylvania)H-Index: 46
Last.Irene L. Andrulis (Lunenfeld-Tanenbaum Research Institute)H-Index: 39
view all 256 authors...
Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.
134 CitationsSource
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