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Tom L. Blundell
University of Cambridge
781Publications
97H-index
42.7kCitations
Publications 781
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#1Asma Munir (University of Cambridge)
#2Narender Kumar (University of Cambridge)H-Index: 9
Last.Sony Malhotra (University of Cambridge)H-Index: 5
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Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis. There is an urgent need to understand the mechanisms by which the mutations confer resistance in order to identify new drug targets and to design new drugs. Previous studies have reported numerous mutations that confer resistance to anti-TB drugs, but there has been little systematic analysis to understand their genetic background a...
#1Liviu Copoiu (University of Cambridge)
#2Pedro Henrique Monteiro Torres (University of Cambridge)H-Index: 1
Last.Sony Malhotra (University of Cambridge)H-Index: 5
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#1Mihaly Varadi (EMBL-EBI: European Bioinformatics Institute)H-Index: 9
#2John M. Berrisford (EMBL-EBI: European Bioinformatics Institute)H-Index: 14
Last.Sameer Velankar (EMBL-EBI: European Bioinformatics Institute)H-Index: 23
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#1Qian Wu (University of Cambridge)H-Index: 10
#2Shikang Liang (University of Cambridge)H-Index: 2
Last.Tom L. Blundell (University of Cambridge)H-Index: 97
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Abstract DNA double-strand breaks (DSBs), generated by ionizing radiation, reactive oxygen species and DNA replication across nicks, are the most severe DNA damage in eukaryotic cells. Non-Homologous End Joining repairs DNA double-strand breaks directly without a template and so can take place at any point in the cell cycle. Ku70/80 heterodimers rapidly assemble around broken DNA ends, allowing DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase, to be recruited and facilitating syna...
Abstract X-ray crystallography and electron microscopy maps resolved to 3–8 A are generally sufficient for tracing the path of the polypeptide chain in space, while often insufficient for unambiguously registering the sequence on the path (i.e., threading). Frequently, however, additional information is available from other biophysical experiments, physical principles, statistical analyses, and other prior models. Here, we formulate an integrative approach for sequence assignment to a partial ba...
#1Nadine Homeyer (Dund.: University of Dundee)H-Index: 1
#2Ruud van Deursen (Dund.: University of Dundee)
Last.Ian H. Gilbert (Dund.: University of Dundee)H-Index: 38
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Abstract Many drug discovery programmes, particularly for infectious diseases, are conducted phenotypically. Identifying the targets of phenotypic screening hits experimentally is complex, time-consuming, and expensive. However, it would be valuable to know what the molecular target(s) is, as knowledge of the binding pose of the hit molecule in the binding site can facilitate the compound optimisation. Furthermore, knowing the target would allow de-prioritisation of less attractive chemical seri...
#1David B. AscherH-Index: 24
#2A. PacittoH-Index: 5
Last.Tom L. BlundellH-Index: 97
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