Daniel H. Geschwind
University of California, Los Angeles
What is this?
Publications 600
#1Omer Ali Bayraktar (University of Cambridge)H-Index: 7
#2Theresa Bartels (University of Cambridge)H-Index: 2
Last. Kirti Prakash (University of Cambridge)H-Index: 1
view all 25 authors...
Although the cerebral cortex is organized into six excitatory neuronal layers, it is unclear whether glial cells show distinct layering. In the present study, we developed a high-content pipeline, the large-area spatial transcriptomic (LaST) map, which can quantify single-cell gene expression in situ. Screening 46 candidate genes for astrocyte diversity across the mouse cortex, we identified superficial, mid and deep astrocyte identities in gradient layer patterns that were distinct from those o...
2 CitationsSource
#1C. L. Hartl (University of California, Berkeley)
#1Christopher Hartl (UCLA: University of California, Los Angeles)H-Index: 3
Last. Daniel H. Geschwind (UCLA: University of California, Los Angeles)H-Index: 129
view all 10 authors...
Gene networks have proven their utility for elucidating transcriptome structure in the brain, yielding numerous biological insights. Most analyses have focused on expression relationships within a circumspect number of regions - how these relationships vary across a broad array of brain regions is largely unknown. By leveraging RNA-sequencing in 864 samples representing 12 brain regions in a cohort of 131 phenotypically normal individuals, we identify 12 brain-wide, 114 region-specific, and 50 c...
#1Leanna M. Hernandez (UCLA: University of California, Los Angeles)H-Index: 13
#3N Tanya Padgaonkar (UCLA: University of California, Los Angeles)
Last. Elizabeth H. Aylward (Seattle Children's Research Institute)H-Index: 67
view all 19 authors...
Autism spectrum disorder (ASD) is more prevalent in males than in females, but the neurobiological mechanisms that give rise to this sex-bias are poorly understood. The female protective hypothesis suggests that the manifestation of ASD in females requires higher cumulative genetic and environmental risk relative to males. Here, we test this hypothesis by assessing the additive impact of several ASD-associated OXTR variants on reward network resting-state functional connectivity in males and fem...
Last. Aarno PalotieH-Index: 99
view all 52 authors...
#1Kathie J. NgoH-Index: 1
#2Jessica E. RexachH-Index: 5
Last. Brent L. FogelH-Index: 21
view all 26 authors...
1 CitationsSource
#1Katrina M. Moore (UCL: University College London)H-Index: 1
#2Jennifer M. Nicholas (Lond: University of London)H-Index: 20
Last. Daniel H. GeschwindH-Index: 129
view all 171 authors...
Summary Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods In this international, retrospective cohort study, we col...
2 CitationsSource
#1Jennifer K. Forsyth (UCLA: University of California, Los Angeles)H-Index: 15
#2Daniel Nachun (UCLA: University of California, Los Angeles)H-Index: 2
Last. Carrie E. Bearden (UCLA: University of California, Los Angeles)H-Index: 59
view all 7 authors...
Abstract Background 22q11.2 copy number variants are among the most highly penetrant genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia (SCZ) and autism spectrum disorder (ASD). However, the specific mechanisms through which they confer risk remain unclear. Methods Using a functional genomics approach, we integrated transcriptomic data from the developing human brain, genome-wide association findings for SCZ and ASD, protein interaction data, and gene expres...
#1Dan Liang (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#2Angela L. Elwell (UNC: University of North Carolina at Chapel Hill)H-Index: 1
Last. Janet L. Stein (UNC: University of North Carolina at Chapel Hill)H-Index: 96
view all 15 authors...
Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements active during cortical neurogenesis. However, the mechanisms mediating the effects of genetic variants on gene regulation are poorly understood. To determine the functional impact of common genetic variation on the non-coding genome longitudinally during human cortical development, we performed a chromatin accessibility quantitative trait loci (caQTL) analysis in neural progenitor cells and their differentiated...
1 CitationsSource
#1Phil H. LeeH-Index: 39
#2Verneri AnttilaH-Index: 31
Last. Jordan W. SmollerH-Index: 78
view all 605 authors...
Summary Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. ...
14 CitationsSource
#1William Renthal (Harvard University)H-Index: 27
#2Ivan Tochitsky (Harvard University)H-Index: 10
Last. Clifford J. Woolf (Harvard University)H-Index: 127
view all 8 authors...
Primary somatosensory neurons are specialized to transmit specific types of sensory information through differences in cell size, myelination, and the expression of distinct receptors and ion channels, which together define their transcriptional and functional identity. By transcriptionally profiling sensory ganglia at single-cell resolution, we find that different somatosensory neuronal subtypes undergo a remarkably consistent and dramatic transcriptional response to peripheral nerve injury tha...