Muge Yemisci
Hacettepe University
Publications 39
#1Muge Yemisci (Hacettepe University)H-Index: 15
#2Katharina Eikermann-Haerter (Harvard University)H-Index: 21
Background Population-based studies have highlighted a close relationship between migraine and stroke. Migraine, especially with aura, is a risk factor for both ischemic and hemorrhagic stroke. Interestingly, stroke risk is highest for migraineurs who are young and otherwise healthy.
#1Luis Alarcón-Martínez (Hacettepe University)H-Index: 17
#2Sinem Yilmaz-Ozcan (Hacettepe University)H-Index: 1
Last.Turgay Dalkara (Hacettepe University)H-Index: 42
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Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological roles in various neurodegenerative processes. Microvascular pericytes contract during cerebral and coronary ischemia and do not relax after re-opening of the occluded artery, causing incomplete reperfusion. However, the cellular mechanisms underlying ischemia-induced pericyte contraction, its delayed emergence, and whether it is pharmacologically reversible are unclear. Here, we investigate i) whether i...
#1Hulya Karatas (Hacettepe University)H-Index: 9
#2Muge Yemisci (Hacettepe University)H-Index: 15
Last.Turgay Dalkara (Hacettepe University)H-Index: 42
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#1Turgay Dalkara (Hacettepe University)H-Index: 42
#2Luis Alarcón-Martínez (UdeM: Université de Montréal)H-Index: 17
Last.Muge Yemisci (Hacettepe University)H-Index: 15
view all 3 authors...
Recent stroke research has shifted the focus to the microvasculature from neuron-centric views. It is increasingly recognized that a successful neuroprotection is not feasible without microvascular protection. On the other hand, recent studies on pericytes, long-neglected cells on microvessels have provided insight into the regulation of microcirculation. Pericytes play an essential role in matching the metabolic demand of nervous tissue with the blood flow in addition to regulating the developm...
#1Anisa Dehghani (Hacettepe University)
#2Hulya Karatas (Hacettepe University)H-Index: 9
Last.Turgay Dalkara (Hacettepe University)H-Index: 42
view all 7 authors...
The initial phase of neuronal death is not well characterized. Here, we show that expansion of the nuclear membrane without losing its integrity along with peripheralization of chromatin are immediate signs of neuronal injury. Importantly, these changes can be identified with commonly used nuclear stains and used as markers of poor perfusion-fixation. Although frozen sections are widely used, no markers are available to ensure that the observed changes were not confounded by perfusion-induced hy...
#1Serafí CambrayH-Index: 3
#2Manuel Portero-OtinH-Index: 48
Last.Buket Dönmez-Demir (Hacettepe University)H-Index: 3
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Determining the time of stroke onset in order to apply recanalization therapies within the accepted therapeutic window and the correct diagnosis of transient ischemic attack (TIA) are two common clinical problems in acute cerebral ischemia management. Therefore, biomarkers helping in this conundrum could be very helpful. We developed mouse models of distal middle cerebral artery occlusion mimicking TIA and ischemic stroke (IS), respectively. Plasma samples were analyzed by metabolomics at 6, 12,...
#1Buket Dönmez-Demir (Hacettepe University)H-Index: 3
#2Muge Yemisci (Hacettepe University)H-Index: 15
Last.Turgay Dalkara (Hacettepe University)H-Index: 42
view all 3 authors...
Abstract The data presented in this article are related to the research article entitled “Microembolism of single cortical arterioles can induce spreading depression and ischemic injury; a potential trigger for migraine and related MRI lesions” (Donmez-Demir et al., 2018) [1]. This article presents data showing that thrombosis of a small ascending cortical vein (25 µm) in the mouse may also trigger spreading depression as does penetrating arteriole occlusion, although less frequently (22% vs. 10...
#2Muge YemisciH-Index: 15
Last.Turgay DalkaraH-Index: 42
view all 7 authors...
Background and Purpose— Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized that microvascular protection was essential for achieving effective reperfusion and, hence, neuroprotection. To test this hypothesis, we have developed an in vivo model to differentially monitor parenchymal and vascular reactive oxygen species (ROS) formation. By comparing the RO...
#1Luis Alarcón-Martínez (Hacettepe University)H-Index: 17
#2Sinem Yilmaz-Ozcan (Hacettepe University)H-Index: 1
Last.Turgay Dalkara (Hacettepe University)H-Index: 42
view all 8 authors...
Blood vessels in animals’ bodies are highly organized. The large blood vessels from the heart branch to smaller vessels that are spread throughout the tissues. The smallest vessels, the capillaries, allow oxygen and nutrients to pass from the blood to nearby cells in tissues. Some capillaries, including those at the back of the eye (in the retina) and those in the brain, change their diameter in response to activity in the nervous system. This allows more or less oxygen and nutrients to be deliv...