David Della-Morte
University of Rome Tor Vergata
EndocrinologyPhysical therapyStrokeDiabetes mellitusMedicine
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Publications 171
#1Francesco CurcioH-Index: 27
#2Gianluca TestaH-Index: 22
Last. Pasquale AbeteH-Index: 29
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Modifications of lean mass are a frequent critical determinant in the pathophysiology and progression of heart failure (HF). Sarcopenia may be considered one of the most important causes of low physical performance and reduced cardiorespiratory fitness in older patients with HF. Sarcopenia is frequently misdiagnosed as cachexia. However, muscle wasting in HF has different pathogenetic features in sarcopenic and cachectic conditions. HF may induce sarcopenia through common pathogenetic pathways s...
Type 2 myocardial infarctions (T2-MI) is a type of necrosis that results from reduced oxygen supply and/or increased demand secondary to other causes unrelated to acute coronary atherothrombosis. The development and implementation of sensitive and high-sensitivity cardiac necrosis marker and the age-related increase of comorbidity lead to a boost of the frequency of T2-MI. T2-MI is often a complication of a high degree of clinical frailty in older adults, emerging as a “geriatric syndrome”. Age-...
#1Roberto Arriga (University of Rome Tor Vergata)H-Index: 8
#2Francesca Pacifici (University of Rome Tor Vergata)H-Index: 7
Last. Davide Lauro (University of Rome Tor Vergata)H-Index: 43
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Insulin action and often glucose-stimulated insulin secretion are reduced in obesity. In addition, the excessive intake of lipids increases oxidative stress leading to overt type 2 diabetes mellitus (T2DM). Among the antioxidative defense systems, peroxiredoxin 6 (PRDX6) is able to reduce H2O2 and short chain and phospholipid hydroperoxides. Increasing evidences suggest that PRDX6 is involved in the pathogenesis of atherosclerosis and T2DM, but its role in the etiopathology of obesity and its co...
Sirtuins (SIRTs) are seven nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases enzymes (SIRT1–7) that play an important role in maintaining cellular homeostasis. Among those, the most studied are SIRT1 and SIRT3, a nuclear SIRT and a mitochondrial SIRT, respectively, which significantly impact with an increase in mammals’ lifespan by modulating metabolic cellular processes. Particularly, when activated, both SIRT1 and 3 enhance pancreatic β-cells’ insulin release and reduce i...
#2Marco InfanteH-Index: 1
Last. David Della-MorteH-Index: 26
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Atherosclerosis is an inflammatory chronic disease affecting arterial vessels and leading to vascular diseases, such as stroke and myocardial infarction. The relationship between atherosclerosis and risk of neurodegeneration has been established, in particular with vascular cognitive impairment and dementia (VCID). Systemic atherosclerosis increases the risk of VCID by inducing cerebral infarction, or through systemic or local inflammatory factors that underlie both atherosclerosis and cognition...
6 CitationsSource
#2Fiorella Guadagni (OU: Open University)H-Index: 35
Last. Raffaele Palmirotta (University of Bari)H-Index: 26
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ABSTRACTMigraine is a common multifactorial and polygenic neurological disabling disorder characterized by a genetic background and associated to environmental, hormonal and food stimulations. A large series of evidence suggest a strong correlation between nutrition and migraine and indicates several commonly foods, food additives and beverages that may be involved in the mechanisms triggering the headache attack in migraine-susceptible persons. There are foods and drinks, or ingredients of the ...
1 CitationsSource
#1Piero BarbantiH-Index: 24
#2Fiorella GuadagniH-Index: 35
Last. Raffaele PalmirottaH-Index: 26
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Dopamine-beta-hydroxylase (DBH) enzyme activity is modulated at the genetic level by the presence of several polymorphisms. Among these, the 19-bp insertion/deletion (I/D) polymorphism (rs72393728/rs141116007) was investigated in several genetic association studies for its correlation with the susceptibility to develop episodic migraine, but conflicting results were achieved. In the present study we analyzed this genetic variant in a carefully characterized population of migraineurs encompassing...
#1David Della-Morte (University of Rome Tor Vergata)H-Index: 26
Neurodegenerative diseases are among the leading causes of mortality and disability worldwide. However, current therapeutic approaches have failed to reach significant results in their prevention and cure. Protein Kinase Cs (PKCs) are kinases involved in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s Disease (AD) and cerebral ischemia. Specifically e, δ, and γPKC are associated with the endogenous mechanism of protection referred to as ischemic preconditioning (IPC). Exis...
#1Francesca PacificiH-Index: 7
#2David Della-MorteH-Index: 26
Last. Davide LauroH-Index: 43
view all 9 authors...
Background: Diabetes is a multifactorial disease with low levels of inflammation and loss of functional pancreatic β-cell mass. Pancreatic β-cells have a reduced antioxidant capacity with an increased vulnerability to oxidative stress. Pro-inflammatory cytokines increasing reactive oxygen species production lead to cell death. Peroxiredoxin6 (Prdx6), an antioxidant enzyme, is highly expressed in beta cells compared to other antioxidants. We previously reported as Prdx6 knockout (Prdx6 -/- ) mice...