David Klatzmann
University of Paris
Publications 424
Commenting on Meyer et al 1 our recent publication2 ‘Immunological and clinical effects of low-dose interleukin-2 (IL-2) across 11 autoimmune diseases in a single, open clinical trial’, Dr Meyer and colleagues point to the issue of concomitant background therapies that could affect the effects of low-dose IL-2. They reported a significant increase of Treg cell frequencies in peripheral blood of patients with rheumatoid arthritis treated with methotrexate, adalimumab, etanercept, golimumab and to...
#1C. AnquetilH-Index: 1
Last.Yves AllenbachH-Index: 21
view all 14 authors...
Introduction Actuellement, les inhibiteurs de check-points immunitaires (ICI) sont recommandes pour le traitement de plus de 16 types de cancers differents et le nombre de patients eligibles ne cesse d’augmenter notamment avec l’approbation recente dans le cancer du sein. La gestion des toxicites immunitaires induites par ces anticorps monoclonaux anti-cytotoxic-T-lymphocyte-associated protein-4 (CTLA4) ou anti-programme cell death 1/programme cell death ligand 1 (PD1/PDL1) devient cruciale. En ...
#1Marianela C. Serradell (CONICET: National Scientific and Technical Research Council)H-Index: 3
#2Lucía L. Rupil (CONICET: National Scientific and Technical Research Council)H-Index: 3
Last.Hugo D. Luján (CONICET: National Scientific and Technical Research Council)H-Index: 23
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Intestinal and free-living protozoa, such as Giardia lamblia, express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host’s intestine. Here we show that VSPs not only are resistant to proteolytic digestion and extreme pH and temperatures but also stimulate host innate immune responses in a TLR-4 dependent manner. We show that these properties can be exploited to both protect and adjuvant vaccine antigens for oral administration. Chi...
6 CitationsSource
#1Cloé ComarmondH-Index: 18
#2Valérie Lorin (French Institute of Health and Medical Research)H-Index: 8
Last.David Saadoun (University of Paris)H-Index: 20
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Abstract Background & Aims Hepatitis C virus (HCV) infection contributes to the development of autoimmune disorders such as cryoglobulinemia vasculitis (CV). However, it remains unclear why only some HCV-infected individuals develop CV. HCV-CV is characterized by expansions of anergic CD19 + CD27 + CD21 low/- atypical memory B cells (AtM). Here, we report the mechanisms by which AtM participate to HCV-associated autoimmunity. Methods Phenotype and function of peripheral AtM were studied by multi...
In this issue, Zhang et al report that a short course of low-dose IL-2 improved patients with polymyositis or dermatomyositis. This adds to the list of diseases for which efficacy of low-dose IL-2 has been reported.1 This is in line with the main activity of low-dose IL-2, the stimulation and expansion of regulatory T cells (Tregs).1 Tregs are key to maintaining immune homeostasis. They control inflammation and the activation of effector T cells with autoimmune potential.2 Their depletion immedi...
#1Marie Pouzolles (University of Montpellier)H-Index: 2
#2Alice Machado (University of Montpellier)H-Index: 1
Last.Valérie S. Zimmermann (University of Montpellier)H-Index: 18
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Background Patients with T-cell immunodeficiencies are generally treated with allogeneic hematopoietic stem cell transplantation, but alternatives are needed for patients without matched donors. An innovative intrathymic gene therapy approach that directly targets the thymus might improve outcomes. Objective We sought to determine the efficacy of intrathymic adeno-associated virus (AAV) serotypes to transduce thymocyte subsets and correct the T-cell immunodeficiency in a zeta-associated protein ...
1 CitationsSource
#1Sebastien Halter (University of Paris)
#2Lucrèce Aimade (University of Paris)
Last.Antoine Monsel (University of Paris)H-Index: 18
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Abstract Backgrounds Acute respiratory distress syndrome (ARDS) is a common and fatal inflammatory condition. Whether T regulatory cells (Tregs) are beneficial or detrimental remains controversial, and longitudinal studies are lacking. Phenotyping of Tregs activation markers has been poorly reported. We aimed to evaluate quantitative and functional alterations in blood and bronchoalveolar Treg phenotype of ARDS patients. Methods We performed a single-centre observational study in a French intens...
#1Janaína F. Barros (UFRJ: Federal University of Rio de Janeiro)H-Index: 2
#2Ingrid Waclawiak (UFRJ: Federal University of Rio de Janeiro)H-Index: 1
Last.Claudia F. Benjamim (UFRJ: Federal University of Rio de Janeiro)H-Index: 23
view all 13 authors...
Wound healing is a well-coordinated process that involves inflammatory mediators and cellular responses; however, if any disturbances are present during this process, tissue repair is impaired. Chronic wounds are one of the serious long-term complications associated with diabetes mellitus. The chemokine receptor CCR4 and its respective ligands, CCL17 and CCL22, are involved in regulatory T cell recruitment and activation in inflamed skin; however, the role of regulatory T cells in wounds is stil...
2 CitationsSource
#1Paul-Gydeon Ritvo (University of Paris)H-Index: 2
#2David Klatzmann (University of Paris)H-Index: 63
The role of Interleukin-1 on the regulation of humoral responses is poorly documented in contrast to its role on inflammation. Recent findings suggested an interleukin-1 axis in the follicular T cell control of B cell responses, implicating interleukin-1 receptors (IL-1R1 and IL-1R2) and receptor antagonists (IL-1Ra). Here, we revisit the literature on this topic and conclude that targeting the interleukin-1 pathway should be a valuable therapeutic approach in many diseases implicating an excess...
1 CitationsSource