Laurent Beaugerie
Pierre-and-Marie-Curie University
Publications 335
#1Julien KirchgesnerH-Index: 8
Last.Laurent BeaugerieH-Index: 53
view all 5 authors...
Objective Patients with IBD are at increased risk of acute arterial events. Antitumour necrosis factor (TNF) agents and thiopurines may, via their anti-inflammatory properties, lower the risk of acute arterial events. The aim of this study was to assess the impact of thiopurines and anti-TNFs on the risk of acute arterial events in patients with IBD. Design Patients aged 18 years or older and affiliated to the French national health insurance with a diagnosis of IBD were followed up from 1 April...
#2Florent Malard (University of Paris)H-Index: 17
Last.Mohamad Mohty (University of Paris)H-Index: 54
view all 15 authors...
Fecal microbiota transplantation is an effective treatment in recurrent Clostridium difficile infection. Promising results to eradicate multidrug-resistant bacteria have also been reported with this procedure, but there are safety concerns in immunocompromised patients. We report results in 10 adult patients colonized with multidrug-resistant bacteria, undergoing fecal microbiota transplantation before (n=4) or after (n=6) allogeneic hematopoietic stem cell transplantation for hematologic malign...
10 CitationsSource
#1Nassim Hammoudi (University of Paris)H-Index: 1
Last.Matthieu Allez (University of Paris)H-Index: 33
view all 90 authors...
Background and Aims Different types of histologic lesions at the ileal margin, detected by histology, have been associated with increased rates of recurrence after ileocaecal surgery in patients with Crohn’s disease (CD). We aimed to characterize histologic features of the ileal margin and to evaluate their association with disease recurrence. Methods We collected histologic data from 211 patients with ileal or ileocolonic CD who underwent ileocolonic resections at hospitals in France from Septe...
1 CitationsSource
#1Hugues Aschard (Harvard University)H-Index: 21
#2Vincent Laville (Pasteur Institute)H-Index: 2
Last.Harry Sokol (Agro ParisTech)H-Index: 2
view all 14 authors...
Several bacteria in the gut microbiota have been shown to be associated with inflammatory bowel disease (IBD), and dozens of IBD genetic variants have been identified in genome-wide association studies. However, the role of the microbiota in the etiology of IBD in terms of host genetic susceptibility remains unclear. Here, we studied the association between four major genetic variants associated with an increased risk of IBD and bacterial taxa in up to 633 IBD cases. We performed systematic scre...
2 CitationsSource
Objective Regulatory T cells (Tregs) prevent autoimmunity and control inflammation. Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose interleukin-2 (ld-IL2) expands and activates Tregs, it has a broad therapeutic potential. Aim We aimed to assess this potential and select diseases for further clinical development by cross-investigating the effects of ld-IL2 in a single clinical trial treating patients with 1 of 11 autoimmune diseases. Methods We perfo...
22 CitationsSource
#1Harry SokolH-Index: 48
#2Nizar Mahlaoui (Necker-Enfants Malades Hospital)H-Index: 41
Last.Alain FischerH-Index: 124
view all 27 authors...
3 CitationsSource
#1Magali Svrcek (UPMC: Pierre-and-Marie-Curie University)H-Index: 26
#2Paula Borralho Nunes (University of Lisbon)H-Index: 4
Last.Roger Feakins (Barts Health NHS Trust)H-Index: 29
view all 8 authors...
Compared to the general population, patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer. Molecular mechanisms underlying colorectal carcinogenesis in the setting of IBD are not well understood. However, modern molecular investigative tools have facilitated the identification of features that help distinguish IBD-related carcinoma from sporadic. Moreover, with advances in endoscopic technology and improved understanding of the natural history, the...
1 CitationsSource
#1Guillaume Le GallH-Index: 1
#2Julien KirchgesnerH-Index: 8
Last.Laurent BeaugerieH-Index: 53
view all 9 authors...
#1Julien Kirchgesner (University of Paris)H-Index: 8
#2Laurent BeaugerieH-Index: 53
Last.Michaël Schwarzinger (Paris Diderot University)H-Index: 20
view all 6 authors...
Objective Magnitude and independent drivers of the risk of acute arterial events in IBD are still unclear. We addressed this question in patients with IBD compared with the general population at a nationwide level. Design Using the French National Hospital Discharge Database from 2008 to 2013, all patients aged 15 years or older and diagnosed with IBD were identified and followed up until 31 December 2013. The rates of incident acute arterial events were calculated and the impact of time with ac...
19 CitationsSource