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Laia Rofes
Autonomous University of Barcelona
SwallowingOropharyngeal dysphagiaDysphagiaDiabetes mellitusMedicine
47Publications
18H-index
1,215Citations
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Publications 47
Newest
#1Christopher Cabib (Autonomous University of Barcelona)H-Index: 2
#2Weslania Nascimento (Autonomous University of Barcelona)H-Index: 2
Last. Omar Ortega (Autonomous University of Barcelona)H-Index: 12
view all 10 authors...
BACKGROUND: Neurorehabilitation strategies for chronic poststroke (PS) oropharyngeal dysphagia (OD) have been mainly focused on the neurostimulation of the pharyngeal motor cortex with only marginal effects. In contrast, treatments targeting the PS oropharyngeal sensory pathway dysfunction offer very promising results, but there is little knowledge on the underlying mechanisms. We aimed to explore the neurophysiological mechanisms behind the effect of three sensory neurostimulation strategies. M...
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#1Noemí Tomsen (Autonomous University of Barcelona)H-Index: 2
#2Daniel Alvarez-Berdugo (ISCIII: Carlos III Health Institute)H-Index: 7
Last. Lluís MundetH-Index: 3
view all 13 authors...
BACKGROUND: Oropharyngeal dysphagia (OD) treatment is moving away from compensatory strategies toward active treatments that improve swallowing function. The aim of this study was to assess the acute therapeutic effect of TRPA1/M8 agonists in improving swallowing function in OD patients. METHODS: Fifty-eight patients with OD caused by aging, stroke, or neurodegenerative disease were included in a three-arm, quadruple-blind, randomized clinical trial (NCT02193438). Swallowing safety and efficacy ...
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#1Christopher Cabib (Autonomous University of Barcelona)H-Index: 2
#2Weslania Nascimento (Autonomous University of Barcelona)H-Index: 2
Last. Omar Ortega (Autonomous University of Barcelona)H-Index: 12
view all 11 authors...
Oropharyngeal dysphagia (OD) is a common post-stroke complication and is associated with respiratory infections. The aim was to assess the biomechanical impairments in swallow function and the afferent and efferent swallowing pathways impairing swallow safety in chronic post-stroke patients. We studied 30 patients with unilateral stroke and chronic OD (> 3 months from stroke onset) with impaired safety of swallow (Penetration–Aspiration Scale [PAS] ≥ 2). We evaluated the efficacy, safety, and ki...
2 CitationsSource
#1Mireia Bolivar‐Prados (Autonomous University of Barcelona)H-Index: 1
#2Laia RofesH-Index: 18
Last. Pere Clavé (Autonomous University of Barcelona)H-Index: 38
view all 11 authors...
BACKGROUND: Increasing viscosity with thickening agents is a valid therapeutic strategy for oropharyngeal dysphagia (OD). To assess the therapeutic effect of a xanthan gum-based thickener (Nutilis Clear® ) at six viscosities compared with thin liquid in poststroke OD (PSOD) patients. METHODS: A total of 120 patients with PSOD were studied in this controlled, multiple-dose, fixed-order, and single-blind study using videofluoroscopy (VFSS). A series of boluses of 10 mL thin liquid and 2000, 1400, ...
3 CitationsSource
#1Viridiana Arreola (Autonomous University of Barcelona)H-Index: 17
#2Natalia Vilardell (Autonomous University of Barcelona)H-Index: 9
Last. Pere Clavé (Autonomous University of Barcelona)H-Index: 38
view all 8 authors...
Oropharyngeal dysphagia is a prevalent complication following stroke (PS-OD), and one that is sometimes spontaneously recovered. This study describes the natural history of PS-OD between admission and three months post-stroke, and the factors associated with its prevalence and development. PS-OD was assessed with the volume-viscosity swallow test (V-VST) in all stroke patients on admission and at the three-month follow-up. We analyzed clinical, demographic, and neuroanatomical factors of 247 old...
2 CitationsSource
#1Lluís Mundet (ISCIII: Carlos III Health Institute)H-Index: 3
#2Christopher CabibH-Index: 2
Last. Pere Clavé (ISCIII: Carlos III Health Institute)H-Index: 38
view all 8 authors...
Background/Aims: Fecal incontinence (FI) is a prevalent condition among women. While biomechanical motor components have been thoroughly researched, anorectal sensory aspects are less known. We studied the pathophysiology of FI in community-dwelling women, specifically, the conduction through efferent/afferent neural pathways. Methods: A cross-sectional study was conducted on 175 women with FI and 19 healthy volunteers. The functional/structural study included anorectal manometry/endoanal ultras...
1 CitationsSource
#1Noemí Tomsen (ISCIII: Carlos III Health Institute)H-Index: 2
#2Omar Ortega (ISCIII: Carlos III Health Institute)H-Index: 12
Last. Pere Clavé (ISCIII: Carlos III Health Institute)H-Index: 38
view all 7 authors...
Background:Older people with oropharyngeal dysphagia (OD) present a decline in pharyngeal sensory function. The aim of this proof-of-concept study was to assess the biomechanical and neurophysiolog...
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#1Marta Miarons (ISCIII: Carlos III Health Institute)H-Index: 1
#2Laia Rofes (ISCIII: Carlos III Health Institute)H-Index: 18
Abstract Objective The purpose of this systematic review was to examine the effect of antipsychotic medication on dysphagia based on clinical case reports. Patients and methods Literature searches were performed using the electronic databases PubMed and Embase. In PubMed, we used the MeSH terms “antipsychotic agents” OR “tranquilizing agents” combined with “deglutition disorders” OR “deglutition”. In Embase, we used the Emtree terms “neuroleptic agents” combined with “swallowing” OR “dysphagia”....
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#1Daniel Alvarez-Berdugo (ISCIII: Carlos III Health Institute)H-Index: 7
#2Laia Rofes (ISCIII: Carlos III Health Institute)H-Index: 18
Last. Pere Clavé (ISCIII: Carlos III Health Institute)H-Index: 38
view all 8 authors...
BACKGROUND: Oropharyngeal dysphagia (OD) is a prevalent disease with poor prognosis among older people and has no pharmacological treatment. Polymodal sensory receptors like the TRP or ASIC family receptors are potential targets to treat OD. TRPM8 agonists and acidic solutions can improve the swallow response in patients with OD, but little is known about the expression of TRPM8, ASIC1, and ASIC3 in the human oropharynx. The aim of this study was to assess the expression and localization of TRPM...
2 CitationsSource
#1Marta MiaronsH-Index: 1
#2Pere Clavé (Autonomous University of Barcelona)H-Index: 38
Last. Laia Rofes (ISCIII: Carlos III Health Institute)H-Index: 18
view all 7 authors...
Abstract Objectives The objective of this study was to assess the pathophysiology of oropharyngeal dysphagia (OD) in patients with dementia, specifically in those taking antipsychotics (APs). Design A cross-sectional study was performed from January 2011 to May 2017 in a general hospital. Setting and Participants We included 114 patients with dementia, of which 39 (34.2%) were taking APs (82.5 ± 7.8 years, Barthel Index 52.28 ± 30.42) and 29 patients without dementia (82.4 ± 6.7 years, Barthel I...
1 CitationsSource
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