Nathalie Mignet
University of Paris
Publications 104
Abstract Achieving drug delivery at the ocular level encounters many challenges and obstacles. In situ gelling delivery systems are now widely used for topical ocular administration and recognized as a promising strategy to improve the treatment of a wide range of ocular diseases. The present work describes the formulation and evaluation of a mucoadhesive and ion-activated in situ gelling delivery system based on gellan gum and hydroxyethylcellulose for the delivery of phenylephrine and tropicam...
#1Shayan Ahmed (Paris V: Paris Descartes University)
#2Yohann Corvis (Paris V: Paris Descartes University)H-Index: 10
Last.Nathalie Mignet (Paris V: Paris Descartes University)H-Index: 19
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Abstract Liposomes are nanocarriers composed of phospholipids, especially designed to potentially carry drugs. However, liposomes suffer in terms of leakage of small hydrophilic drugs. To control the release, a system with lipid shell and polymeric viscous core, namely Hybrid liposome/polymer inside (HLP in ), has been designed. For this purpose, we setup a syringe pump apparatus equipped with homemade tubing system. HLPin formulation consisting of poloxamer (5% w/v) was found to be optimal when...
#1Khair Alhareth (Paris V: Paris Descartes University)H-Index: 3
#2Lucie ValeroH-Index: 2
Last.Karine Andrieux (Paris V: Paris Descartes University)H-Index: 1
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Abstract Controlled distribution of a drug by its association to a nanocarrier is a promising approach for the treatment of pregnancy disorders such as preeclampsia. For this application, tracking both the nanocarrier and the drug is necessary to ensure the safety of both the mother and the foetus. This study reports a method to visualize and quantify the uptake of liposomal formulations in placental tissue using florescent labelling and appropriate analytical tools. Lipoplexes were labelled wit...
#1Katia Lemdani (University of Paris)H-Index: 1
#2Johanne Seguin (University of Paris)H-Index: 22
Last.Nathalie Mignet (University of Paris)H-Index: 19
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Abstract Intratumoral injection of biocompatible gels is increasingly used for the sustained delivery of drugs and vaccines to enhance the anti-cancer immune response. Granulocyte-macrophage colony stimulating factor (GM-CSF) has become an attractive adjuvant thanks to its ability to boost the antitumor immune response by inducing proliferation, maturation and migration of the dendritic-cells (DCs) and the differentiation of lymphocytes. Killed Mycobacteria, such as Heat-killed Mycobacterium tub...
#1Hugo Salmon (Paris V: Paris Descartes University)H-Index: 2
#2Rabah Gahoual (Paris V: Paris Descartes University)H-Index: 11
Last.Nathalie Mignet (Paris V: Paris Descartes University)H-Index: 19
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Abstract Lactosylated albumin is currently used as a radiopharmaceutical agent to image the liver asialoglycoprotein receptors and quantify hepatic liver function in various diseases. A lactosylated protein (LACTAL) conjugate showed excellent liver uptake compared to non-lactosylated protein and a high signal to noise ratio, based on the biodistribution in mice using 99mTc-scintigraphy. However, in the laboratory, it is useful to have a method that can be used in daily practice to quantify cellu...
1 CitationsSource
#1Wassef Khaled (Sorbonne)H-Index: 1
#2Joao Piraquive (Sorbonne)H-Index: 1
Last.Bernard E. Van Beers (Sorbonne)H-Index: 15
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1 CitationsSource
Purpose The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic liposomes (UML) into CT26 murine colon tumor by magnetic resonance imaging (MRI).
#1Katia LemdaniH-Index: 1
#2Nathalie MignetH-Index: 19
Last.Robert MalafosseH-Index: 8
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ABSTRACTRadiofrequency ablation (RFA) of colorectal liver metastases activates a specific T-cell response that is ineffective in avoiding recurrence. Recently, local immunomodulation garnered interests as a way to improve the immune response. We were interested in improving the RFA immune response priming to propose a curative treatment of colorectal cancer (CRC) based on antitumor immunity. First, we demonstrated that the RFA did not increase the tumor infiltrating lymphocytes in secondary dist...
2 CitationsSource
#1Brice Martin Couillaud (Paris V: Paris Descartes University)H-Index: 1
#2Philippe Espeau (Paris V: Paris Descartes University)H-Index: 12
Last.Yohann Corvis (Paris V: Paris Descartes University)H-Index: 10
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4 CitationsSource
#2Philippe EspeauH-Index: 12
Last.Yohann CorvisH-Index: 10
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