Jon Kobashigawa
Cedars-Sinai Medical Center
CardiologyIntensive care medicineHeart transplantationTransplantationMedicine
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Publications 1071
PURPOSE OF REVIEW: The present article will review the diagnosis of antibody-mediated rejection in heart transplant recipients and further explore the clinical implications. RECENT FINDINGS: Improved diagnostic techniques have led to increased recognition of antibody-mediated rejection and better understanding of the long-term consequences in heart transplant recipients. Endomyocardial biopsy remains the gold standard for the diagnosis of antibody-medicated ejection; however, several advances in...
#1Alexandre Loupy (University of Paris)H-Index: 24
#2G. Coutance (University of Paris)H-Index: 2
Last. Jean-Paul Duong Van Huyen (University of Paris)H-Index: 1
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Background: Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant (HTx) recipient mortality. Little is known about the prototypes of CAV trajectories at the population lev...
#1Robert J. H. Miller (U of C: University of Calgary)H-Index: 2
#2Jacek Kwiecinski (Edin.: University of Edinburgh)H-Index: 6
Last. Damini Dey (Cedars-Sinai Medical Center)H-Index: 38
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Cardiac allograft vasculopathy (CAV) is an increasingly important complication after cardiac transplant. We assessed the additive diagnostic benefit of quantitative plaque analysis in patients undergoing coronary computed tomography-angiography (CCTA). Consecutive patients undergoing CCTA for CAV surveillance were identified. Scans were visually interpreted for coronary stenosis. Semiautomated software was used to quantify noncalcified plaque (NCP), as well as its components. Optimal diagnostic ...
#1Xiaohai Zhang (Cedars-Sinai Medical Center)H-Index: 4
#2Evan P. Kransdorf (Cedars-Sinai Medical Center)H-Index: 7
Last. Jon Kobashigawa (Cedars-Sinai Medical Center)H-Index: 62
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Abstract The development of donor specific antibody is associated with graft rejection and increased mortality in solid organ transplant recipients. The majority of de novo donor specific antibodies (dnDSA) are against HLA-DQ antigens, but it has not been investigated if this is caused by more mismatches in the HLA-DQ locus between the recipient and donor. Here we examined the impact of HLA mismatches in eight HLA loci on the development of dnDSA and on rejection in a large cohort of heart trans...
#1Jack Aguilar (Cedars-Sinai Medical Center)
#2David Chang (Cedars-Sinai Medical Center)H-Index: 81
Last. Jon Kobashigawa (Cedars-Sinai Medical Center)H-Index: 62
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JC virus associated nephropathy is rare in kidney transplant recipients, and even rarer in recipients of other solid organ transplants. We present a case of JC virus-associated nephropathy in a heart-kidney transplant recipient, which to our knowledge is the first case reported in the literature. We discuss the findings on renal biopsy for JC virus nephropathy and our management approach to this rare complication.
#1Krishan Patel (SC: University of Southern California)
#2Tina Kao (Cedars-Sinai Medical Center)
Last. Jignesh Patel (Cedars-Sinai Medical Center)H-Index: 33
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#1Joe X. Xie (Emory University)H-Index: 4
#2Jon Kobashigawa (Cedars-Sinai Medical Center)H-Index: 62
Last. S. Tanveer Rab (Emory University)H-Index: 10
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Importance: Guidelines endorse routine coronary angiography and percutaneous coronary intervention (PCI) to screen for and treat cardiac allograft vasculopathy in heart transplant recipients. However, the current Appropriate Use Criteria for Revascularization (AUC-R) do not recognize prior heart transplant as a unique PCI indication. Whether this affects rates of rarely appropriate (RA) PCIs is unknown. Objective: To assess the rate of RA PCI procedures in heart transplant recipients and how it ...
#1Ersilia M. DeFilippis (Columbia University)H-Index: 1
#2Jennifer Haythe (Columbia University)H-Index: 10
Last. Michelle Kittleson (Cedars-Sinai Medical Center)H-Index: 16
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BACKGROUND: Pregnancy after heart transplantation (HT) is a concern for many female recipients. The International Society for Heart and Lung Transplantation has guidelines regarding reproductive health, but limited data exist regarding providers' attitudes and practices surrounding pregnancy post-HT. METHODS: We conducted an independent, confidential, voluntary, web-based survey sent electronically to 1643 United States heart transplant providers between June and August 2019. RESULTS: There were...
#1Jignesh Patel (Cedars-Sinai Medical Center)H-Index: 33
#2Michelle Kittleson (Cedars-Sinai Medical Center)H-Index: 16
Last. Fardad Esmailian (Cedars-Sinai Medical Center)H-Index: 14
view all 11 authors...
Purpose Sensitized patients have prolonged wait times for heart transplant and often low-level donor specific antibodies (DSA) will be crossed when accepting a donor heart. The purpose of this study was to determine if positive low-level DSA at the time of transplant increase in strength post transplant and increase the risk of antibody mediated rejection (AMR). Methods We reviewed 72 heart transplant patients between 2010 and 2018 in whom low-level DSA were crossed. DSA strength, as measured by...