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Nicolò Salvarani
National Research Council
CardiologyMyofibroblastDepolarizationBiologyCell biology
33Publications
11H-index
422Citations
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Publications 35
Newest
Last. Leonardo Elia (University of Brescia)H-Index: 16
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Rationale: microRNAs (miRNAs) are small non-coding RNAs that modulate gene expression by negatively regulating translation of target genes. While the role of several miRNAs in vascular smooth muscl...
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#1M Barandalla Sobrados (National Research Council)
#2Pierluigi Carullo (National Research Council)H-Index: 16
Last. Daniele Catalucci (National Research Council)H-Index: 31
view all 6 authors...
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#1Nicolò Salvarani (National Research Council)H-Index: 11
#2Silvia Crasto (National Research Council)H-Index: 2
Last. Elisa Di Pasquale (National Research Council)H-Index: 12
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Mutations in LMNA, which encodes the nuclear proteins Lamin A/C, can cause cardiomyopathy and conduction disorders. Here, we employ induced pluripotent stem cells (iPSCs) generated from human cells carrying heterozygous K219T mutation on LMNA to develop a disease model. Cardiomyocytes differentiated from these iPSCs, and which thus carry K219T-LMNA, have altered action potential, reduced peak sodium current and diminished conduction velocity. Moreover, they have significantly downregulated Nav1....
4 CitationsSource
#1Michele Miragoli (University of Parma)H-Index: 17
#2Paola Ceriotti (National Research Council)H-Index: 4
Last. Daniele Catalucci (National Research Council)H-Index: 31
view all 20 authors...
Peptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure, thus representing scientific and technological challenges. We demonstrate that inhalation of small (
23 CitationsSource
#1Roberto Papait (National Research Council)H-Index: 15
#2Simone SerioH-Index: 4
Last. Gianluigi Condorelli (National Research Council)H-Index: 65
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Background: Correct gene expression programming of the cardiomyocyte underlies the normal functioning of the heart. Alterations to this can lead to the loss of cardiac homeostasis, triggering heart dysfunction. Although the role of some histone methyltransferases in establishing the transcriptional program of postnatal cardiomyocytes during heart development has been shown, the function of this class of epigenetic enzymes is largely unexplored in the adult heart. In this study, we investigated t...
18 CitationsSource
#1Silvia CrastoH-Index: 2
#2Nicolò SalvaraniH-Index: 11
Last. Elisa Di PasqualeH-Index: 12
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Mutations of the LMNA gene, encoding the nuclear lamina proteins Lamin A/C, are a common cause of dilated cardiomyopathy, typically manifesting in association with cardiac conduction defects. Lamin...
#1Nicolò Salvarani (University of Bern)H-Index: 11
#2Ange Maguy (University of Bern)H-Index: 2
Last. Stephan Rohr (University of Bern)H-Index: 29
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Background— TGF-β 1 (transforming growth factor-β 1 ) importantly contributes to cardiac fibrosis by controlling differentiation, migration, and collagen secretion of cardiac myofibroblasts. It is still elusive, however, to which extent TGF-β 1 alters the electrophysiological phenotype of myofibroblasts and cardiomyocytes and whether it affects proarrhythmic myofibroblast–cardiomyocyte crosstalk observed in vitro. Methods and Results— Patch-clamp recordings of cultured neonatal rat ventricular m...
13 CitationsSource
#1Francesca RusconiH-Index: 7
#2Paola CeriottiH-Index: 4
Last. Daniele CatalucciH-Index: 31
view all 19 authors...
Background: L-type calcium channels (LTCCs) play important roles in regulating cardiomyocyte physiology, which is governed by appropriate LTCC trafficking to and density at the cell surface. Factors influencing the expression, half-life, subcellular trafficking, and gating of LTCCs are therefore critically involved in conditions of cardiac physiology and disease. Methods: Yeast 2-hybrid screenings, biochemical and molecular evaluations, protein interaction assays, fluorescence microscopy, struct...
1 CitationsSource
#1Francesca Rusconi (National Research Council)H-Index: 7
#2Paola CeriottiH-Index: 4
Last. Daniele Catalucci (National Research Council)H-Index: 31
view all 19 authors...
Background —L-type calcium channels (LTCCs) play important roles in regulating cardiomyocyte physiology, which is governed by an appropriate LTCC trafficking to and density at the cell surface. Factors influencing the expression, half-life, subcellular trafficking, and gating of LTCCs are therefore critically involved in conditions of cardiac physiology and disease. Methods —Yeast two-hybrid screenings, biochemical and molecular evaluations, protein interaction assays, fluorescence microscopy, s...
2 CitationsSource
#1Francesca Rusconi (National Research Council)H-Index: 7
#2Paola CeriottiH-Index: 4
Last. Daniele Catalucci (National Research Council)H-Index: 31
view all 19 authors...
Background: L-type calcium channels (LTCCs) play important roles in regulating cardiomyocyte physiology, which is governed by appropriate LTCC trafficking to and density at the cell surface. Factors influencing the expression, half-life, subcellular trafficking, and gating of LTCCs are therefore critically involved in conditions of cardiac physiology and disease. Methods: Yeast 2-hybrid screenings, biochemical and molecular evaluations, protein interaction assays, fluorescence microscopy, struct...
18 CitationsSource
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