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Nicolò Salvarani
National Research Council
31Publications
9H-index
371Citations
Publications 31
Newest
#1Nicolò Salvarani (National Research Council)H-Index: 9
#2Silvia Crasto (National Research Council)H-Index: 1
Last.Carla Lucarelli (University of Verona)
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Mutations in LMNA, which encodes the nuclear proteins Lamin A/C, can cause cardiomyopathy and conduction disorders. Here, we employ induced pluripotent stem cells (iPSCs) generated from human cells carrying heterozygous K219T mutation on LMNA to develop a disease model. Cardiomyocytes differentiated from these iPSCs, and which thus carry K219T-LMNA, have altered action potential, reduced peak sodium current and diminished conduction velocity. Moreover, they have significantly downregulated Nav1....
#1Michele Miragoli (University of Parma)H-Index: 16
#2Paola Ceriotti (National Research Council)H-Index: 3
Last.Lorenzo Degli Esposti (National Research Council)H-Index: 2
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Peptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure, thus representing scientific and technological challenges. We demonstrate that inhalation of small (
#1Roberto Papait (National Research Council)H-Index: 11
#2Simone SerioH-Index: 1
Last.Gianluigi Condorelli (National Research Council)H-Index: 64
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Background: Correct gene expression programming of the cardiomyocyte underlies the normal functioning of the heart. Alterations to this can lead to the loss of cardiac homeostasis, triggering heart dysfunction. Although the role of some histone methyltransferases in establishing the transcriptional program of postnatal cardiomyocytes during heart development has been shown, the function of this class of epigenetic enzymes is largely unexplored in the adult heart. In this study, we investigated t...
#1Silvia CrastoH-Index: 1
#2Nicolò SalvaraniH-Index: 9
Last.Elisa Di PasqualeH-Index: 12
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Mutations of the LMNA gene, encoding the nuclear lamina proteins Lamin A/C, are a common cause of dilated cardiomyopathy, typically manifesting in association with cardiac conduction defects. LaminA/C regulate various nuclear activities, including maintenance of the nuclear structure, gene transcription and chromatin organization. Most studies on the consequences of Lamin A/C defects were conducted on fibroblasts, while studies on human cardiomyocytes (CMs) are scarce. We therefore generated a c...
#1Nicolò Salvarani (University of Bern)H-Index: 9
#2Ange Maguy (University of Bern)H-Index: 2
Last.Stephan Rohr (University of Bern)H-Index: 28
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Background— TGF-β 1 (transforming growth factor-β 1 ) importantly contributes to cardiac fibrosis by controlling differentiation, migration, and collagen secretion of cardiac myofibroblasts. It is still elusive, however, to which extent TGF-β 1 alters the electrophysiological phenotype of myofibroblasts and cardiomyocytes and whether it affects proarrhythmic myofibroblast–cardiomyocyte crosstalk observed in vitro. Methods and Results— Patch-clamp recordings of cultured neonatal rat ventricular m...
#1Francesca Rusconi (National Research Council)H-Index: 7
#2Paola CeriottiH-Index: 3
Last.Silvia CaprariH-Index: 4
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Background —L-type calcium channels (LTCCs) play important roles in regulating cardiomyocyte physiology, which is governed by an appropriate LTCC trafficking to and density at the cell surface. Factors influencing the expression, half-life, subcellular trafficking, and gating of LTCCs are therefore critically involved in conditions of cardiac physiology and disease. Methods —Yeast two-hybrid screenings, biochemical and molecular evaluations, protein interaction assays, fluorescence microscopy, s...
#1Francesca Rusconi (National Research Council)H-Index: 7
#2Paola CeriottiH-Index: 3
Last.Silvia CaprariH-Index: 4
view all 19 authors...
Background: L-type calcium channels (LTCCs) play important roles in regulating cardiomyocyte physiology, which is governed by appropriate LTCC trafficking to and density at the cell surface. Factors influencing the expression, half-life, subcellular trafficking, and gating of LTCCs are therefore critically involved in conditions of cardiac physiology and disease. Methods: Yeast 2-hybrid screenings, biochemical and molecular evaluations, protein interaction assays, fluorescence microscopy, struct...
#1Nafiseh Baheiraei (TMU: Tarbiat Modares University)H-Index: 9
#2Reza GharibiH-Index: 8
Last.Gianluigi CondorelliH-Index: 64
view all 7 authors...
In first part of this experiment, biocompatibility of the newly developed electroactive polyurethane/siloxane films containing aniline tetramer moieties was demonstrated with proliferation and differentiation of C2C12 myoblasts. Here we further assessed the cytocompatibility of the prepared samples with HL1-cell line, the electrophysiological properties and the patch clamp recording of the seeded cells over the selected electroactive sample. Presence of electroactive aniline tetramer in the stru...
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