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Anat R. Tambur
Northwestern University
Human leukocyte antigenImmunologyTransplantationMedicineBiology
167Publications
25H-index
2,223Citations
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Publications 175
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#1Cynthia Garcia‐Sanchez (NU: Northwestern University)
#2Crystal Y Usenko (NU: Northwestern University)
Last. Anat R. Tambur (NU: Northwestern University)H-Index: 25
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#2Roslyn B. MannonH-Index: 38
Last. Philip J. O'ConnellH-Index: 39
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With the development of modern solid-phase assays to detect anti-HLA antibodies and a more precise histological classification, the diagnosis of antibody-mediated rejection (AMR) has become more common and is a major cause of kidney graft loss. Currently, there are no approved therapies and treatment guidelines are based on low level evidence. The number of prospective randomized trials for the treatment of AMR is small and the lack of an accepted common standard for care has been an impediment ...
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#1Anat R. Tambur (NU: Northwestern University)H-Index: 25
#2Patricia Campbell (U of A: University of Alberta)H-Index: 21
Last. Roslyn B. Mannon (UA: University of Alabama)H-Index: 38
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The purpose of the STAR 2019 Working Group was to build on findings from the initial STAR report to further clarify the expectations, limitations, perceptions, and utility of alloimmune assays that are currently in use or in development for risk assessment in the setting of organ transplantation. The goal was to determine the precision and clinical feasibility/utility of such assays in evaluating both memory and primary alloimmune risks. The process included a critical review of biologically dri...
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#1David F. Pinelli (NU: Northwestern University)H-Index: 6
#2Anat R. Tambur (NU: Northwestern University)H-Index: 25
1 CitationsSource
#1Navchetan Kaur (Tulane University)H-Index: 4
#2David F. Pinelli (NU: Northwestern University)H-Index: 6
Last. Loren Gragert (Tulane University)H-Index: 17
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Abstract Virtual crossmatch (VXM) compares a transplant candidate’s unacceptable antigens to the HLA typing of the donor before an organ offer is accepted and, in selected cases, supplant a prospective physical crossmatch. However, deceased donor typing can be ambiguous, leading to uncertainty in compatibility prediction. We have developed a prototype web application that utilizes ambiguous HLA molecular typing data to predict which unacceptable antigens are present in the donor HLA genotype as ...
1 CitationsSource
#1Charles F. Manski (NU: Northwestern University)H-Index: 63
#2Anat R. Tambur (NU: Northwestern University)H-Index: 25
Last. Michael Gmeiner (NU: Northwestern University)H-Index: 1
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We consider prediction of graft survival when a kidney from a deceased donor is transplanted into a recipient, with a focus on the variation of survival with degree of human leukocyte antigen (HLA) mismatch. Previous studies have used data from the Scientific Registry of Transplant Recipients (SRTR) to predict survival conditional on partial characterization of HLA mismatch. Whereas earlier studies assumed proportional hazards models, we used nonparametric regression methods. These do not make t...
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#1Anat R. Tambur (NU: Northwestern University)H-Index: 25
#2Hannah McDowell (NU: Northwestern University)
Last. David F. Pinelli (NU: Northwestern University)H-Index: 6
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#1Navchetan Kaur (Tulane University)H-Index: 4
#2David F. Pinelli (NU: Northwestern University)H-Index: 6
Last. Loren Gragert (Tulane University)H-Index: 17
view all 10 authors...
Virtual crossmatch (VXM) compares a transplant candidate9s unacceptable antigens to the HLA typing of the donor before an organ offer is accepted and, in selected cases, supplant a prospective physical crossmatch. However, deceased donor typing can be ambiguous, leading to uncertainty in compatibility prediction. We have developed a web application that utilizes ambiguous HLA molecular typing data to assist in VXM assessments. The application compares a candidate9s listed unacceptable antigens t...
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#1David F. Pinelli (NU: Northwestern University)H-Index: 6
#2Hannah McDowell (NU: Northwestern University)
Last. Anat R. Tambur (NU: Northwestern University)H-Index: 25
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