Neil Poulter
Imperial College London
EndocrinologyCardiologyDiabetes mellitusMedicineBlood pressure
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Publications 515
#1Hyunju Kim (Johns Hopkins University)H-Index: 7
#2Dan Wang (Johns Hopkins University)H-Index: 3
Last. Neil Poulter (Imperial College London)H-Index: 74
view all 14 authors...
BACKGROUND Creatinine-based estimated glomerular filtration rate (eGFR) is biased in the setting of obesity and other conditions. Alternative kidney filtration markers may be useful in adults with diabetes, but few studies examined the associations with risk of clinical outcomes. METHODS In the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial, we evaluated whether baseline levels and change in eGFR based on creatinine (Cr), cy...
#1Toshiaki Ohkuma (The George Institute for Global Health)H-Index: 13
#1Toshiaki Ohkuma (The George Institute for Global Health)H-Index: 2
Last. Mark Woodward (Johns Hopkins University)H-Index: 121
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AIMS Sex differences in associations between several risk factors and myocardial infarction (MI), including diabetes, have been found in general populations. Whether similar differences are observed in patients with diabetes is unknown. MATERIALS AND METHODS 11,065 (42% women) participants with type 2 diabetes in the ADVANCE trial and its post-trial follow-up study, ADVANCE-ON, were included. Cox regression models were used to estimate hazard ratios (HRs) for associations between risk factors an...
#1Thomas Beaney (NIH: National Institutes of Health)H-Index: 1
#1Thomas Beaney (Imperial College London)H-Index: 3
Last. Walter G. EspecheH-Index: 7
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Elevated blood pressure remains the single biggest risk factor contributing to the global burden of disease and mortality. May Measurement Month is an annual global screening campaign aiming to imp...
1 CitationsSource
#1Katie Harris (The George Institute for Global Health)H-Index: 3
#1Katie Harris (The George Institute for Global Health)
Last. John Chalmers (The George Institute for Global Health)H-Index: 87
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AIMS/HYPOTHESIS: This biomarker study aimed to quantify the association of essential and other plasma fatty acid biomarkers with macrovascular disease, microvascular disease and death in individuals with type 2 diabetes. METHODS: A case-cohort study (N = 3576), including 654 macrovascular events, 341 microvascular events and 631 deaths during 5 years of (median) follow-up, was undertaken as a secondary analysis of the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Relea...
#1John B. Buse (UNC: University of North Carolina at Chapel Hill)H-Index: 98
#2Stephen C. Bain (Swansea University)H-Index: 28
Last. Tea Monk Fries (Novo Nordisk)H-Index: 4
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OBJECTIVE The LEADER trial ( reg. no. NCT01179048) demonstrated a reduced risk of cardiovascular (CV) events for patients with type 2 diabetes who received the glucagon-like peptide 1 receptor agonist liraglutide versus placebo. The mechanisms behind this CV benefit remain unclear. We aimed to identify potential mediators for the CV benefit observed with liraglutide in the LEADER trial. RESEARCH DESIGN AND METHODS We performed exploratory analyses to identify potential mediator...
1 CitationsSource
#1Greg Guthrie (Dund.: University of Dundee)H-Index: 1
#2Neil Poulter (Imperial College London)H-Index: 74
Last. David J. Webb (Edin.: University of Edinburgh)H-Index: 87
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This commentary refers to ‘Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial’, by R.C. Hermida et al., doi:10.1093/eurheartj/ehz754.
2 CitationsSource
Last. Vamadevan S. Ajay (Public Health Foundation of India)H-Index: 16
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Abstract Background Given the shortage of cardiac rehabilitation (CR) programs in India and poor uptake worldwide, there is an urgent need to find alternative models of CR that are inexpensive and may offer choice to subgroups with poor uptake (e.g., women and elderly). Objectives This study sought to evaluate the effects of yoga-based CR (Yoga-CaRe) on major cardiovascular events and self-rated health in a multicenter randomized controlled trial. Methods The trial was conducted in 24 medical ce...
5 CitationsSource
#1Simon Heller (University of Sheffield)H-Index: 62
#2Ildiko Lingvay (UTSW: University of Texas Southwestern Medical Center)H-Index: 21
Last. Martin Lange (Novo Nordisk)H-Index: 7
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AIMS: To undertake a post hoc analysis, utilizing a hypoglycaemia risk score based on DEVOTE trial data, to investigate if a high risk of severe hypoglycaemia was associated with an increased risk of cardiovascular events, and whether reduced rates of severe hypoglycaemia in patients identified as having the highest risk impacted the risk of cardiovascular outcomes. MATERIALS AND METHODS: The DEVOTE population was divided into quartiles according to patients' individual hypoglycaemia risk scores...
#1Jingyan Tian (SJTU: Shanghai Jiao Tong University)H-Index: 8
#1Jingyan Tian (SJTU: Shanghai Jiao Tong University)
Last. John Chalmers (The George Institute for Global Health)H-Index: 87
view all 10 authors...
OBJECTIVE To study whether the effects of intensive glycemic control on major vascular outcomes (a composite of major macrovascular and major microvascular events), all-cause mortality, and severe hypoglycemia events differ among participants with different levels of 10-year risk of atherosclerotic cardiovascular disease (ASCVD) and hemoglobin A1c (HbA1c) at baseline. RESEARCH DESIGN AND METHODS We studied the effects of more intensive glycemic control in 11,071 patients with type 2 diabetes (T2...
#1Steven P. MarsoH-Index: 50
#2Florian M.M. Baeres (Novo Nordisk)H-Index: 6
Last. John B. Buse (UNC: University of North Carolina at Chapel Hill)H-Index: 98
view all 11 authors...
Abstract Background More data regarding effects of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes (T2D) and heart failure (HF) are required. Objectives The purpose of this study was to investigate the effects of liraglutide on cardiovascular events and mortality in LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) participants, by HF history. Methods In the multinational, double-blind, randomized LEADER trial, 9,340 patie...
2 CitationsSource