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Clifford S. Deutschman
The Feinstein Institute for Medical Research
Intensive care medicineImmunologySepsisAnesthesiaMedicine
205Publications
34H-index
17.8kCitations
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Publications 203
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Last. Clifford S. Deutschman (The Feinstein Institute for Medical Research)H-Index: 34
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#1Daniel Leisman (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 7
#2Clifford S. Deutschman (The Feinstein Institute for Medical Research)H-Index: 34
Last. Matthieu Legrand (UCSF: University of California, San Francisco)H-Index: 25
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#1Daniel LeismanH-Index: 7
Abstract: Sepsis is a syndrome that affects millions of patients worldwide. Despite this burden, the pathobiology of the disorder is poorly understood. Over the past three decades, three separate expert task forces have attempted to define sepsis. The final approach, Sepsis-3, is unique because it differentiates the definition from clinical criteria that might be used to identify patients with sepsis. This chapter reviews the Sepsis-3 definition and provides the scientific rationale and clinical...
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#1Daniel LeismanH-Index: 7
#2Tiago FernandesH-Index: 1
Last. Clifford S. DeutschmanH-Index: 34
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#1Scott L. WeissH-Index: 18
Last. Douglas C. WallaceH-Index: 122
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OBJECTIVE: Immune dysregulation is a defining feature of sepsis, but the role for mitochondria in the development of immunoparalysis in pediatric sepsis is not known. We sought to determine if mitochondrial dysfunction measured in peripheral blood mononuclear cells (PBMCs) is associated with immunoparalysis and systemic inflammation in children with sepsis. DESIGN: Prospective observational study SETTING:: Single academic pediatric intensive care unit (PICU) PATIENTS:: 161 children with sepsis/s...
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#1Mabel AbrahamH-Index: 1
Last. Clifford S. DeutschmanH-Index: 34
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Outcomes variables for research on sepsis have centered on mortality and changes in the host immune response. However, a recent task force (Sepsis-3) revised the definition of sepsis to "life-threatening organ dysfunction caused by a dysregulated host response to infection". This new definition suggests that human studies should focus on organ dysfunction. The appropriate criteria for organ dysfunction in either human sepsis or animal models are, however, poorly delineated, limiting the potentia...
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#1Weiqiang ChenH-Index: 4
#2Max BrennerH-Index: 13
Last. Hanmin WangH-Index: 68
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ABSTRACTSepsis can be simulated in animals by perforating the cecum via a surgical procedure termed “cecal ligation and puncture” (CLP), which induces similar inflammatory responses as observed during the clinical course of human sepsis. In addition to anesthetic agents, many Institutional Animal Ca
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