Match!
Nelson M.S. Wat
Caritas Medical Centre
EndocrinologyPopulationRisk factorDiabetes mellitusMedicine
36Publications
22H-index
2,583Citations
What is this?
Publications 36
Newest
#1Jianchao Quan (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 3
#2Deanette Pang (Singapore Ministry of Health)H-Index: 1
Last. Gabriel M. Leung (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 62
view all 11 authors...
Source
#1Yc Woo (HKU: University of Hong Kong)H-Index: 4
#2Annette W.K. Tso (HKU: University of Hong Kong)H-Index: 26
Last. Karen S.L. Lam (HKU: University of Hong Kong)H-Index: 68
view all 10 authors...
Background Adipose tissue inflammation and dysregulated adipokine secretion are implicated in obesity-related insulin resistance and type 2 diabetes. We evaluated the use of serum adiponectin, an anti-inflammatory adipokine, and several proinflammatory adipokines, as biomarkers of diabetes risk and whether they add to traditional risk factors in diabetes prediction. Methods We studied 1300 non-diabetic subjects from the prospective Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). ...
17 CitationsSource
#1Cheng Chen (HKU: University of Hong Kong)H-Index: 5
#2Annette W.K. Tso (HKU: University of Hong Kong)H-Index: 26
Last. Karen S.L. Lam (HKU: University of Hong Kong)H-Index: 68
view all 9 authors...
Summary Objectives Pigment epithelium-derived factor (PEDF) is secreted from the adipose tissue. It circulates at high concentrations, and was reported to play a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Previous cross-sectional studies also demonstrated plasma PEDF concentration correlated positively with systolic blood pressure (BP) and pulse pressure, and inversely with small artery elasticity. Here we investigated the relationship of plasma PEDF co...
6 CitationsSource
#1Cheng ChenH-Index: 5
#2Bernard M.Y. CheungH-Index: 43
Last. Karen S.L. LamH-Index: 68
view all 9 authors...
OBJECTIVE To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study. RESEARCH DESIGN AND METHODS Baseline plasma FGF21 levels were measured using an enzyme-linked immunosorbent assay in 1,900 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). The prospective association of FGF21 with d...
105 CitationsSource
#1Kwok Leung Ong (HKU: University of Hong Kong)H-Index: 26
#2Annette W.K. Tso (HKU: University of Hong Kong)H-Index: 26
Last. Ksl Lam (HKU: University of Hong Kong)H-Index: 25
view all 10 authors...
Aims/hypothesis Hypoadiponectinaemia and raised C-reactive protein (CRP) level are obesity-related biomarkers associated with glucose dysregulation. We evaluated the combined use of these two biomarkers in predicting the deterioration of glycaemia in a prospective study after a median of 5.4 years.
20 CitationsSource
Objective: Central obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population. In this study, we investigate whether these SNPs could also predict the persistence of central obe...
25 CitationsSource
#1Lawrence S. C. Law (HKU: University of Hong Kong)H-Index: 15
#2Annette W.K. Tso (HKU: University of Hong Kong)H-Index: 26
Last. Karen S.L. Lam (HKU: University of Hong Kong)H-Index: 68
view all 6 authors...
Abstract Baseline haemoglobin A1c had a higher standardized hazard ratio, and more optimal sensitivity and specificity than fasting glucose in predicting the 8-year incidence of diabetes among 530 non-diabetic Chinese from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study.
10 CitationsSource
#1Chloe Y. Y. CheungH-Index: 8
#2Annette Wk TsoH-Index: 1
Last. Karen S.L. LamH-Index: 68
view all 9 authors...
#1Bernard M.Y. Cheung (University of Birmingham)H-Index: 43
#2Mingfang Li (HKU: University of Hong Kong)H-Index: 7
Last. Karen S.L. Lam (HKU: University of Hong Kong)H-Index: 68
view all 12 authors...
Summary Objectives High-density lipoprotein (HDL) cholesterol is a powerful cardiovascular risk factor. Important gender and ethnic differences in plasma HDL levels exist and warrant investigation. Design Cross-sectional survey in two different general populations. Patients 7700 participants of the National Health and Nutrition Examination Survey (NHANES) 1999–2002 and 1944 participants of the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2) 2000–2004. Measurements Plasma HDL le...
6 CitationsSource
#1Dennis C.Y. YeungH-Index: 7
#2Aimin XuH-Index: 69
Last. Karen S.L. LamH-Index: 68
view all 9 authors...
OBJECTIVE—To investigate the relationships of serum adipocyte fatty acid–binding protein (A-FABP) and epidermal fatty acid–binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS—The associations of serum A-FABP and E-FABP with markers of renal function, nephropathy staging, and macrovascular complications were examined in 237 type 2 diabetic patients. RESULTS—Serum A-FABP and E-FABP correlated significantly with se...
48 CitationsSource
1234