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Tamara Tchkonia
Mayo Clinic
EndocrinologyAdipose tissueSenolyticSenescenceBiology
77Publications
40H-index
6,495Citations
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Publications 84
Newest
#1Seo Rin Kim (Mayo Clinic)H-Index: 2
#2Kai Jiang (Mayo Clinic)H-Index: 8
Last. Lilach O. Lerman (Mayo Clinic)H-Index: 67
view all 10 authors...
Cellular senescence, a permanent arrest of cell proliferation, is characterized by a senescence-associated secretory phenotype (SASP), which reinforces senescence and exerts noxious effects on adjacent cells. Recent studies suggest that transplanting small numbers of senescent cells suffices to provoke tissue inflammation. We hypothesized that senescent cells can directly augment renal injury. Primary scattered tubular-like cells (STC) acquired from pig kidneys were irradiated by 10Gy of cesium ...
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#1Robert J. Pignolo (Mayo Clinic)H-Index: 31
#2João F. Passos (Mayo Clinic)H-Index: 29
Last. James L. Kirkland (Mayo Clinic)H-Index: 55
view all 5 authors...
Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alterations in DNA and chromatin. In preclinical aging models, accumulation of senescent cells is associated with multiple chronic diseases and disorders, geriatric syndromes, multimorbidity, and accelerated aging phenotypes. In animals, genetic and pharmac...
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#1Shuling Song (CAS: Chinese Academy of Sciences)
#2Eric C. Lam (Imperial College London)H-Index: 84
Last. Yu Sun (CAS: Chinese Academy of Sciences)H-Index: 12
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Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illust...
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#1Collin Lahde (UCF: University of Central Florida)
#2Allancer D. C. Nunes (UCF: University of Central Florida)H-Index: 1
Last. Tamara Tchkonia (Mayo Clinic)H-Index: 40
view all 11 authors...
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#1Sundeep Khosla (Mayo Clinic)H-Index: 101
#2Joshua N. Farr (Mayo Clinic)H-Index: 22
Last. James L. Kirkland (Mayo Clinic)H-Index: 55
view all 4 authors...
With the ageing of the global population, interest is growing in the ‘geroscience hypothesis’, which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the appearance or severity of multiple chronic, non-communicable diseases, as these diseases share the same underlying risk factor — namely, ageing. In this context, cellular senescence has received considerable attention as a potential target in preventing or treating multiple age-related diseases and increasing h...
2 CitationsSource
#1LaTonya J. Hickson (Mayo Clinic)H-Index: 16
#2Larissa Prata (Mayo Clinic)H-Index: 3
Last. Kyra L. Jordan (Mayo Clinic)H-Index: 15
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2 CitationsSource
#2Tatiana D. SacconH-Index: 3
Last. Michal M. MasternakH-Index: 30
view all 7 authors...
The uterine fibrosis contributes to gestational outcomes. Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of aging and the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis. Forty mice, 20 young females (03-months) and 20 old females (18-months), were analyzed. Young (Y) and old (O) animals were divided into groups of 10 mice, with one treatm...
4 CitationsSource
#1Marcelo B. Cavalcante (UCF: University of Central Florida)
#2Tatiana Saccon (UCF: University of Central Florida)
Last. Michal M. Masternak (UCF: University of Central Florida)H-Index: 30
view all 7 authors...
Female reproductive function is negatively impacted by age. Animal and human studies show that fibrosis of the uterus contributes to gestational outcomes. Collagen deposition in the myometrial and endometrial layers is the main change related to uterine aging. Senolytic therapies are a potential option for reducing diseases and health complications related to aging. We investigated effects of aging and the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis. A total ...
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#1Sonja Suvakov (Mayo Clinic)H-Index: 1
#2Hajrunisa Cubro (Mayo Clinic)H-Index: 4
Last. Vesna D. Garovic (Mayo Clinic)H-Index: 33
view all 16 authors...
Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities, is one of the mechanisms by which systemic inflammation exerts inhibitory effects on angiogenesis in preeclampsia. MSC were isolated from abdominal fat tissue explants removed during medically indicated C-sections from women with preeclampsia (PE-MSC, n = 10) and those with normotensive p...
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#1Gabriela Colon (FSU: Florida State University)
#2Tatiana Saccon (UCF: University of Central Florida)
Last. Michal M. Masternak (UCF: University of Central Florida)H-Index: 30
view all 14 authors...
Growth hormone (GH) is secreted by the anterior pituitary gland and regulates various metabolic processes throughout the body. GH and IGF-1 levels are markedly reduced in older humans, leading some to hypothesize GH supplementation could be a viable “anti-aging” therapy. However, there is still much debate over the benefits and risks of GH administration. While an early study of GH administration reported reduced adiposity and lipid levels and increased bone mineral density, subsequent studies f...
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