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Garib N. Murshudov
Laboratory of Molecular Biology
172Publications
45H-index
34.1kCitations
Publications 172
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#1Jeffrey J. Lovelace (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 6
#2Vaclav Petricek (CAS: Academy of Sciences of the Czech Republic)H-Index: 16
Last.Gloria E. O. Borgstahl (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 23
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Theoretically, crystals with supercells exist at a unique crossroads where they can be considered as either a large unit cell with closely spaced reflections in reciprocal space or a higher dimensional superspace with a modulation that is commensurate with the supercell. In the latter case, the structure would be defined as an average structure with functions representing a modulation to determine the atomic location in 3D space. Here, a model protein structure and simulated diffraction data wer...
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#1Benjamin Bax (DI: Discovery Institute)H-Index: 26
#2Garib N. Murshudov (LMB: Laboratory of Molecular Biology)H-Index: 45
Last.Thomas Germe (Norwich Research Park)H-Index: 6
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Abstract Type II topoisomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting another DNA segment through this break and then resealing it. Bacterial type IIA topoisomerase inhibitors, such as fluoroquinolones and novel bacterial topoisomerase inhibitors, can trap DNA cleavage complexes with double- or single-stranded cleaved DNA. To study the mode of action of such compounds, 21 crystal structures of a “gyraseCORE” fusion truncate of Staphyloccocus aure...
2 CitationsSource
#1Azzurra CarlonH-Index: 5
#2Enrico Ravera (UniFI: University of Florence)H-Index: 21
Last.Claudio Luchinat (UniFI: University of Florence)H-Index: 64
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Data integration in structural biology has become a paradigm for the characterization of biomolecular systems, and it is now accepted that combining different techniques can fill the gaps in each other’s blind spots. In this frame, one of the combinations, which we have implemented in REFMAC-NMR, is residual dipolar couplings from NMR together with experimental data from X-ray diffraction. The first are exquisitely sensitive to the local details but does not give any information about overall sh...
3 CitationsSource
#1Azzurra CarlonH-Index: 5
#2Enrico Ravera (UniFI: University of Florence)H-Index: 21
Last.Claudio Luchinat (UniFI: University of Florence)H-Index: 64
view all 5 authors...
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#2Garib N. Murshudov (LMB: Laboratory of Molecular Biology)H-Index: 45
This paper describes a global analysis of macromolecular B values. It is shown that the distribution of B values generally follows the shifted inverse-gamma distribution (SIGD). The parameters of the SIGD are estimated using the Fisher scoring technique with the expected Fisher information matrix. It is demonstrated that a contour plot based on the parameters of the SIGD can play a role in the validation of macromolecular structures. The dependence of the peak-height distribution on resolution a...
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#1Paul D. Adams (University of California, Berkeley)H-Index: 84
#2Pavel V. Afonine (LBNL: Lawrence Berkeley National Laboratory)H-Index: 33
Last.Jasmine Young (RU: Rutgers University)H-Index: 17
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1 CitationsSource
#1Ivan Campeotto (University of Oxford)H-Index: 2
#2Andrey A. Lebedev (RAL: Rutherford Appleton Laboratory)H-Index: 20
Last.Arwen R. Pearson (University of Leeds)H-Index: 21
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Twinning is a crystal growth anomaly, which has posed a challenge in macromolecular crystallography (MX) since the earliest days. Many approaches have been used to treat twinned data in order to extract structural information. However, in most cases it is usually simpler to rescreen for new crystallization conditions that yield an untwinned crystal form or, if possible, collect data from non-twinned parts of the crystal. Here, we report 11 structures of engineered variants of the E. coli enzyme ...
2 CitationsSource
#1Benjamin Falcon (LMB: Laboratory of Molecular Biology)H-Index: 10
#2Wenjuan Zhang (LMB: Laboratory of Molecular Biology)H-Index: 4
Last.Michel Goedert (LMB: Laboratory of Molecular Biology)H-Index: 115
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The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases1. Tau assemblies seem to spread through specific neural networks in each disease2, with short filaments having the greatest seeding activity3. The abundance of tau inclusions strongly correlates with disease symptoms4. Six tau isoforms are expressed in the normal adult human brain—three isoforms with four microtubule-binding repeats each (4R tau) and three isoforms that lack t...
74 CitationsSource
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