Match!
Nicola E. Annels
University of Surrey
70Publications
23H-index
3,940Citations
Publications 70
Newest
#1Kate Relph (University of Surrey)H-Index: 8
#2Nicola E. Annels (University of Surrey)H-Index: 23
Last.Hardev Pandha (University of Surrey)H-Index: 46
view all 5 authors...
Source
#1Nicola E. Annels (University of Surrey)H-Index: 23
#2David MansfieldH-Index: 9
Last.Hardev Pandha (University of Surrey)H-Index: 46
view all 18 authors...
Purpose: The CANON [CAVATAK in NON–muscle-invasive bladder cancer (NMIBC)] study evaluated a novel ICAM-1–targeted immunotherapeutic-coxsackievirus A21 as a novel oncolytic agent against bladder cancer. Patients and Methods: Fifteen patients enrolled in this “window of opportunity” phase I study, exposing primary bladder cancers to CAVATAK prior to surgery. The first 9 patients received intravesical administration of monotherapy CAVATAK; in the second stage, 6 patients received CAVATAK with a su...
Source
#1Nicola E. Annels (University of Surrey)H-Index: 23
#2David MansfieldH-Index: 9
Last.Hardev Pandha (University of Surrey)H-Index: 46
view all 18 authors...
Purpose: The CANON (CAVATAK in NON-muscle invasive bladder cancer) study evaluated a novel ICAM-1-targeted immunotherapeutic-coxsackievirus A21 as a novel oncolytic agent against bladder cancer. Experimental Design: Fifteen patients enrolled on this 9window of opportunity9 phase 1 study, exposing primary bladder cancers to CAVATAK prior to surgery. The first nine patients received intravesical administration of monotherapy CAVATAK; in the second stage, six patients received CAVATAK with a sub-th...
4 CitationsSource
#2David CunninghamH-Index: 109
Last.Tony Dhillon (University of Surrey)
view all 15 authors...
TPS3615Background: Colon cancer with deficient mismatch repair (dMMR) and POLE mutations are characterised by a high tumor mutational burden (TMB) and an immunogenic lymphocyte infiltrate. Approxim...
Source
#1Sophie E. McGrath (University of Surrey)H-Index: 5
#2Nicola E. Annels (University of Surrey)H-Index: 23
Last.Agnieszka Michael (University of Surrey)H-Index: 21
view all 8 authors...
Background Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in several cancer types. We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker.
1 CitationsSource
#1Sophie E. McGrathH-Index: 5
#2Nicola E. AnnelsH-Index: 23
Last.Agnieszka MichaelH-Index: 21
view all 8 authors...
BACKGROUND: Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in several cancer types. We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker. METHODS We evaluated 8 Epithelial ovarian cancer cell lines, along with >100 surgical specimens from the Royal Surrey C...
#1Nicola E. Annels (University of Surrey)H-Index: 23
#2Mehreen Arif (University of Surrey)H-Index: 2
Last.Hardev Pandha (University of Surrey)H-Index: 46
view all 14 authors...
As a clinical setting in which local live biological therapy is already well established, non-muscle invasive bladder cancer (NMIBC) presents intriguing opportunities for oncolytic virotherapy. Coxsackievirus A21 (CVA21) is a novel intercellular adhesion molecule-1 (ICAM-1)-targeted immunotherapeutic virus. This study investigated CVA21-induced cytotoxicity in a panel of human bladder cancer cell lines, revealing a range of sensitivities largely correlating with expression of the viral receptor ...
9 CitationsSource
Bladder cancer (BCa) is the most frequent urinary tract neoplasm. BCa results in significant mortality when the disease presents as muscle invasive. Around 75% to 80% of patients present with nonmuscle invasive bladder cancer (NMIBC), but recurrence and progression are significant issues, compelling current guidelines to recommend long-term surveillance. There is therefore an urgent and unmet need to identify and validate accurate biomarkers for the detection of disease recurrence to improve qua...
3 CitationsSource
#1Emma KillickH-Index: 6
#2Richard MorganH-Index: 25
Last.Hardev PandhaH-Index: 46
view all 10 authors...
4653 Background: EN2 is part of the HOX gene family and plays a role in foetal development. More recently a potential oncogenic role for the protein has been postulated and its utility as a cancer biomarker has been explored in prostate cancer (PrCa) and breast cancer. Carriers of mutations in the BRCA1 and BRCA2 genes have an increased risk of PrCa (1.8-fold and 5-fold respectively) and their tumours tend to be more aggressive and advanced than sporadic cases. Currently there is no national scr...
#1Hardev PandhaH-Index: 46
#2Nicola E. AnnelsH-Index: 23
Last.Darren R. ShafrenH-Index: 20
view all 12 authors...
Source
1234567