Bart Loeys
University of Antwerp
CardiologyMarfan syndromeGeneticsMedicineBiology
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Publications 234
#1Sara L. Van Driest (VUMC: Vanderbilt University Medical Center)H-Index: 19
#2Lynn A. Sleeper (Boston Children's Hospital)H-Index: 72
Last. Teresa M. Lee (CUMC: Columbia University Medical Center)H-Index: 5
view all 24 authors...
Objective To test whether variants in ADRB1 and CYP2C9 genes identify subgroups of individuals with differential response to treatment for Marfan syndrome through analysis of data from a large, randomized trial. Study design In a subset of 250 white, non-Hispanic participants with Marfan syndrome in a prior randomized trial of atenolol vs losartan, the common variants rs1801252 and rs1801253 in ADRB1 and rs1799853 and rs1057910 in CYP2C9 were analyzed. The primary outcome was baseline-adjusted a...
#1Aline Verstraeten (University of Antwerp)H-Index: 13
#2Josephina A.N. Meester (University of Antwerp)H-Index: 9
Last. Bart Loeys (Radboud University Nijmegen)H-Index: 44
view all 5 authors...
Although at first glance chondrodysplasia and aneurysmal thoracic aortopathy seem oddly dissimilar, recent lines of evidences indicate that they share molecular similarities. Chondrodysplasias are a group of skeletal disorders characterized by genetic defects in hyaline cartilage. Aneurysmal thoracic aortopathy is the pathological enlargement of the thoracic aorta due to wall weakness, along with its ensuing life-threatening complications (i.e., aortic dissection and/or rupture). Extracellular m...
#1Javier Barallobre-Barreiro ('KCL': King's College London)H-Index: 16
#2Bart LoeysH-Index: 44
Last. Jason C. KovacicH-Index: 36
view all 6 authors...
Highlights •The middle arterial layer, the tunica media, is composed of circumferentially arranged layers of VSMCs that are separated by concentrically arranged elastic lamellae, a form of ECM. •Advances in genetics and proteomics approaches have facilitated dramatic progress in our understanding of the key role of the ECM in vascular health and disease. •The emerging discoveries regarding the role of ECM in the vasculature hold promise to be developed into novel clinical disease biomarkers and ...
#1Joe Davis Velchev (University of Antwerp)
#2Aline Verstraeten (University of Antwerp)H-Index: 13
Last. Bart Loeys (Radboud University Nijmegen)H-Index: 44
view all 3 authors...
In the current issue of JEM, Kang et al. ( describe somatic mutations in the SMAD3 gene causing endosteal melorheostosis. Using osteoblast models, the identified mutations are demonstrated to exert a gain-of-function mechanism, augmenting transforming growth factor (TGF) beta signaling. These findings provide further insights into the genetic etiology of melorheostosis and consolidate the importance of the TGFbeta pathway in skeletal disorders.
#1Najim Lahrouchi (UvA: University of Amsterdam)H-Index: 8
#2Rafik Tadros (MHI: Montreal Heart Institute)H-Index: 12
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Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable cause of sudden cardiac death in the young. A causal rare genetic variant with large effect size is identified...
#1Lidia R. Bons (EUR: Erasmus University Rotterdam)H-Index: 4
#2Laurie W. Geenen (EUR: Erasmus University Rotterdam)H-Index: 3
Last. Marja W. Wessels (EUR: Erasmus University Rotterdam)H-Index: 30
view all 15 authors...
BACKGROUND: Patients with a bicuspid aortic valve (BAV) are at risk of developing valve deterioration and aortic dilatation. We aimed to investigate whether blood biomarkers are associated with disease stage in patients with BAV. METHODS: Serum levels of high sensitivity C-reactive protein (hsCRP), high sensitivity troponin T (hsTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and total transforming growth factor-beta 1 (TGF-ss1) were measured in adult BAV patients with valve dysfunc...
Background: Bicuspid aortic valve (BAV) is the most prevalent congenital heart defect affecting 1% to 2% of the population. It is associated with ascending aorta dilatation. Valve morphology, aorti...
#1Michael Grattan (UWO: University of Western Ontario)H-Index: 5
#2Andrea Prince (Centre Hospitalier Universitaire Sainte-Justine)H-Index: 1
Last. Salah A MohamedH-Index: 14
view all 16 authors...
BACKGROUND: Bicuspid aortic valve (BAV) is the most prevalent congenital heart defect affecting 1% to 2% of the population. It is associated with ascending aorta dilatation. Valve morphology, aortic stenosis (AS), and aortic insufficiency (AI) have been proposed as potential risk factors; however, evaluating their role is difficult, as these factors are inherently related. The aim of this study was to determine whether BAV morphology and dysfunction are independent determinants for ascending aor...
3 CitationsSource
#1Job A. J. Verdonschot (UM: Maastricht University)H-Index: 5
#2Els K. Vanhoutte (UM: Maastricht University)H-Index: 17
Last. Hanne M. Boen (University of Antwerp)H-Index: 1
view all 26 authors...
Filamin C (FLNC) variants are associated with cardiac and muscular phenotypes. Originally, FLNC variants were described in myofibrillar myopathy (MFM) patients. Later, high-throughput screening in cardiomyopathy cohorts determined a prominent role for FLNC in isolated hypertrophic and dilated cardiomyopathies (HCM and DCM). FLNC variants are now among the more prevalent causes of genetic DCM. FLNC-associated DCM is associated with a malignant clinical course and a high risk of sudden cardiac dea...
2 CitationsSource
#1Ingrid M.B.H. van de Laar (EUR: Erasmus University Rotterdam)H-Index: 16
#2Eloisa ArbustiniH-Index: 58
Last. De Backer J (Ghent University Hospital)H-Index: 41
view all 21 authors...
The ACTA2 gene encodes for smooth muscle specific α-actin, a critical component of the contractile apparatus of the vascular smooth muscle cell. Pathogenic variants in the ACTA2 gene are the most frequently encountered genetic cause of non-syndromic hereditary thoracic aortic disease (HTAD). Although thoracic aortic aneurysm and/or dissection is the main clinical manifestation, a variety of occlusive vascular disease and extravascular manifestations occur in ACTA2-related vasculopathy. Current d...
3 CitationsSource