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Nazeh M. Al-Abd
University of Malaya
Brugia malayiLymphatic filariasisBrugia pahangiAntioxidantBiology
12Publications
5H-index
75Citations
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Publications 12
Newest
#1Nazeh M. Al-AbdH-Index: 5
#2Mustafa KassimH-Index: 7
Last. Asdren ZajmiH-Index: 1
view all 3 authors...
Galangin is an active flavonoid compound found in various plants, and is one of the primary constituents of honey and propolis. It has antioxidant, anti-inflammatory, antimicrobial and hepatoprotective properties. This study is intended to evaluate the effects of galangin on cytokines and nitric oxide (NO) secretion from microglia BV2 after being induced with lipopolysaccharide. Microglia BV2 was incubated with Galangin (with and without LPS) and dexamethasone for 24h. NO production in the cultu...
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#1Nazeh M. Al-Abd (UM: University of Malaya)H-Index: 5
#2Zurainee Mohamed Nor (UM: University of Malaya)H-Index: 10
Last. Mustafa Kassim (UM: University of Malaya)H-Index: 7
view all 6 authors...
AbstractLymphatic filariasis (LF) is a vector borne disease caused by parasitic worms such as Wuchereria bancrofti, Brugia malayi and B. timori, which are transmitted by mosquitoes. Current therapeutics to treat LF are mainly microfilarcidal, and lack activity against adult worms. This set back, poses a challenge for the control and elimination of filariasis. Thus, in this study the activities of caffeic acid phenethyl ester (CAPE) against the filarial worm B. pahangi and its bacterial endosymbi...
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#1Nazeh M. Al-Abd (UM: University of Malaya)H-Index: 5
#2Zurainee Mohamed Nor (UM: University of Malaya)H-Index: 10
Last. Mustafa Kassim (UM: University of Malaya)H-Index: 7
view all 7 authors...
Abstract Objective To investigate the antioxidant, antibacterial, and chemical ingredients of Ardisia elliptica ( A. elliptica ) methanolic extracts. Methods The plant was extracted using methanol. Antibacterial and antioxidant activities were evaluated. Results The results showed that both fruit and leaf extract of A. elliptica have significant antibacterial activities against Gram-positive and Gram-negative bacteria. Fruit extracts showed higher content of phenolic (71 ± 0.03 GAE/mg extract dr...
2 CitationsSource
#1Nazeh M. Al-Abd (UM: University of Malaya)H-Index: 5
#2Zurainee Mohamed Nor (UM: University of Malaya)H-Index: 10
Last. Mustafa Kassim (UM: University of Malaya)H-Index: 7
view all 5 authors...
We evaluated the activity of methanolic extracts of Melaleuca cajuputi flowers against the filarial worm Brugia pahangi and its bacterial endosymbiont Wolbachia. Anti-Wolbachia activity was measured in worms and in Aedes albopictus Aa23 cells by PCR, electron microscopy, and other biological assays. In particular, microfilarial release, worm motility, and viability were determined. M. cajuputi flower extracts were found to significantly reduce Wolbachia endosymbionts in Aa23 cells, Wolbachia sur...
1 CitationsSource
#1Nazeh M. Al-Abd (UM: University of Malaya)H-Index: 5
#2Zurainee Mohamed Nor (UM: University of Malaya)H-Index: 10
Last. Mustafa Kassim (UM: University of Malaya)H-Index: 7
view all 6 authors...
Background The threat posed by drug-resistant pathogens has resulted in the increasing momentum in research and development for effective alternative medications. The antioxidant and antibacterial properties of phytochemical extracts makes them attractive alternative complementary medicines. Therefore, this study evaluated the phytochemical constituents of Melaleuca cajuputi flower and leaf (GF and GL, respectively) extracts and their antioxidant and antibacterial activities.
13 CitationsSource
#1Nazeh M. Al-Abd (UM: University of Malaya)H-Index: 5
#2Zurainee Mohamed Nor (UM: University of Malaya)H-Index: 10
Last. Sinnadurai Sivanandam (UM: University of Malaya)H-Index: 6
view all 7 authors...
Abstract Objective To determine the prevalence of the filarial parasites, ie. , Brugia malayi, Brugia, Brugia pahangi ( B. pahangi ), Dirofilaria immitis and Dirofilaria repens ( D. repens ) in domestic and stray cats. Methods A total of 170 blood sample were collected from domestic and stray cats and examined for filarial worm parasites in two localities, Pulau Carey and Bukit Gasing, Selangor State, Malaysia. Results The overall prevalence of infection was 23.5% (40/170; 95% CI = 17.4–30.6). O...
6 CitationsSource
#1Nazeh M. Al-Abd (UM: University of Malaya)H-Index: 5
#2Zurainee Mohamed Nor (UM: University of Malaya)H-Index: 10
Last. Mustafa Kassim (UM: University of Malaya)H-Index: 7
view all 6 authors...
Background: Lymphatic filariasis (LF) is a major cause of permanent disability in many tropical and sub-tropical countries of the world. Malaysia is one of the countries in which LF is an endemic disease. Five rounds of the mass drug administration (MDA) program have been conducted in Malaysia as part of the Global Program to Eliminate Lymphatic Filariasis (GPELF) by year 2020. This study investigated the level of awareness of LF and the MDA program in a population living in an endemic area of t...
4 CitationsSource
#1Mustafa Kassim (UM: University of Malaya)H-Index: 7
#2Marzida MansorH-Index: 11
Last. Kamaruddin Mohd YusoffH-Index: 12
view all 10 authors...
Excessive free radical production by immune cells has been linked to cell death and tissue injury during sepsis. Peroxynitrite is a short-lived oxidant and a potent inducer of cell death that has been identified in several patho- logical conditions. Caffeic acid phenethyl ester (CAPE) is an active component of honeybee products and exhibits anti- oxidant, anti-inflammatory, and immunomodulatory activities. The present study examined the ability of CAPE to scavenge peroxynitrite in RAW 264.7 muri...
8 CitationsSource
Lymphatic filariasis is a parasitic infection that causes a devastating public health and socioeconomic burden with an estimated infection of over 120 million individuals worldwide. The infection is caused by three closely related nematode parasites, namely, Wuchereria bancrofti, Brugia malayi, and B. timori, which are transmitted to human through mosquitoes of Anopheles, Culex, and Aedes genera. The species have many ecological variants and are diversified in terms of their genetic fingerprint....
5 CitationsSource
#1Nazeh M. Al-Abd (UM: University of Malaya)H-Index: 5
#2Mohammed A. K. Mahdy (UM: University of Malaya)H-Index: 17
Last. Mun Y. Fong (UM: University of Malaya)H-Index: 5
view all 7 authors...
Background: The accuracy of the conclusions from in vivo efficacy anti-malarial drug trials depends on distinguishing between recrudescences and re-infections which is accomplished by genotyping genes coding P. falciparum merozoite surface 1 (MSP1) and MSP2. However, the reliability of the PCR analysis depends on the genetic markers’ allelic diversity and variant frequency. In this study the genetic diversity of the genes coding for MSP1 and MSP2 was obtained for P. falciparum parasites circulat...
8 CitationsSource
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