Jaakko Tuomilehto
National Institute for Health and Welfare
Publications 1697
#1Suhad Bahijri (KAU: King Abdulaziz University)H-Index: 14
Last.Jaakko Tuomilehto (National Institute for Health and Welfare)H-Index: 185
view all 8 authors...
#2Abdullah AlkandariH-Index: 2
Last.Jaakko Tuomilehto (National Institute for Health and Welfare)H-Index: 185
view all 8 authors...
Abstract Background Diabetes is prevalent in Kuwait. We aimed to assess the level of glycemic control in Kuwaiti adults with diabetes. Methods The World Health Organization’s STEPS non-communicable disease risk factor survey was conducted in Kuwait in 2014. Participants’ demographics, medical history, physical measurements and blood biochemistry were assessed. A total of 2561 Kuwaiti men and women aged 18–69 years completed all three survey steps. Glycemic control in 278 individuals with diabete...
#1Ruth L. Coleman (University of Oxford)H-Index: 13
#2Charles A. B. Scott (University of Oxford)
Last.Rury R. Holman (University of Oxford)H-Index: 99
view all 6 authors...
Alpha-glucosidase inhibitors (AGIs) have been shown to reduce incident type 2 diabetes but their impact on cardiovascular (CV) disease remains controversial. We sought to identify the overall impact of AGIs with respect to incident type 2 diabetes in individuals with impaired glucose tolerance (IGT), and CV outcomes in those with IGT or type 2 diabetes. We used PubMed and SCOPUS to identify randomized controlled trials reporting the incidence of type 2 diabetes and/or CV outcomes that had compar...
#1Ruth Stephen (University of Eastern Finland)H-Index: 3
#2Yawu Liu (University of Eastern Finland)H-Index: 20
Last.Alina Solomon (KI: Karolinska Institutet)H-Index: 27
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The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimodal intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This study reports exploratory analyses of brain MRI measures. FINGER targeted 1260 older individuals from the general Finnish population. Participants were 60–77 years ol...
1 CitationsSource
#1Peter Nilsson (Lund University)H-Index: 106
#2Jaakko Tuomilehto (National Institute for Health and Welfare)H-Index: 185
Last.Lars Rydén (KI: Karolinska Institutet)H-Index: 6
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A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was es...
1 CitationsSource
#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 33
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 16
Last.Ruth Loos (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
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Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
6 CitationsSource
#1Sheyda Sofizadeh (University of Gothenburg)H-Index: 1
#2Henrik Imberg (Chalmers University of Technology)H-Index: 3
Last.Marcus Lind (University of Gothenburg)H-Index: 16
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Introduction The effects of the GLP-1 analogue liraglutide on time in hypoglycaemia, time in hyperglycaemia, and time in range for type 2 diabetes patients initially treated with multiple daily insulin injections (MDI) were investigated. Variables associated with hypoglycaemia in the current population were also identified.
1 CitationsSource
#1Mohamed Abu-FarhaH-Index: 15
#2Preethi CherianH-Index: 12
Last.Jehad AbubakerH-Index: 27
view all 9 authors...
Obesity impacts the endocrine and metabolic functions of the adipose tissue. There is increasing interest in the role of epigenetic factors in obesity and its impact on diabetes and dyslipidemia. One such substance, miR-181, reduces plasma triglyceride levels in mice by targeting isocitrate dehydrogenase 1. In the other hand, the adipocyte differentiation and lipid regulating hormone angiopoietin-like 3 (ANGPTL3) is a known regulator of circulating apolipoproteins through its inhibition of the l...
#1Sina KavalakattH-Index: 9
#2Abdelkrim KhadirH-Index: 9
Last.Ali TissH-Index: 17
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Urocortin3 (UCN3) regulates metabolic functions and is involved in cellular stress response. Although UCN3 is expressed in human adipose tissue, the association of UCN3 with obesity and diabetes remains unclear. This study investigated the effects of Type 2 diabetes (T2D) and increased body weight on the circulatory and subcutaneous adipose tissue (SAT) levels of UCN3 and assessed UCN3 modulation by a regular physical exercise. Normal-weight (n = 37) and overweight adults with and without T2D (n...