Franck Carbonnel
University of Paris-Sud
Publications 244
Abstract Background Phase III trials demonstrated effectiveness of tofacitinib, an oral Janus kinase inhibitor, to induce and maintain remission in patients with moderate-to-severe active ulcerative colitis (UC). Aims We report the real-world effectiveness and safety of tofacitinib in patients with UC in France. Methods From February 2017 to December 2018, we performed a national French cohort study, which included all consecutive patients with an active UC refractory to anti-TNF and vedolizumab...
#1Clélia CoutzacH-Index: 7
Last.Nathalie ChaputH-Index: 43
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#1Bénédicte Caron (UDS: University of Strasbourg)H-Index: 2
#2Laurent Peyrin-Biroulet (University of Lorraine)H-Index: 59
Last.Aurelien AmiotH-Index: 20
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2 CitationsSource
#1Julia Butt (DKFZ: German Cancer Research Center)H-Index: 9
#2Mazda Jenab (IARC: International Agency for Research on Cancer)H-Index: 66
Last.David J. Hughes (UCD: University College Dublin)H-Index: 14
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Background: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort. Methods: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in pre...
#1Veronika FedirkoH-Index: 40
Last.Mazda JenabH-Index: 66
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Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls f...
#1Antoine Meyer (University of Paris-Sud)H-Index: 1
#2Jérémie Rudant (CNAM: Conservatoire national des arts et métiers)H-Index: 6
Last.Alain Weill (CNAM: Conservatoire national des arts et métiers)H-Index: 28
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#1Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 24
#2Heather Ward (Imperial College London)H-Index: 19
Last.M. J. Gunter (IARC: International Agency for Research on Cancer)H-Index: 40
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Background & Aims Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision. Methods In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumors at...
8 CitationsSource
Background: Vedolizumab (VDZ) is a humanized IgG1 monoclonal antibody anti-α4β7 integrin agent used in inflammatory bowel disease (IBD). It has been incriminated in occurrence of articular manifestations but, as it is given in most cases after anti-TNFα therapy, it is not known if these articular manifestations are linked to IBD-associated arthritis and unmasked by withdrawal of anti-TNFα or are more directly linked to VDZ. Objectives: The purpose of this study is to describe articular manifesta...