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Steven G. Potkin
University of California, Irvine
PsychiatryEndocrinologyPsychologyMedicineSchizophrenia
498Publications
83H-index
25kCitations
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Publications 518
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#1Miriam S. Maes (CAMH: Centre for Addiction and Mental Health)H-Index: 2
#2Justin Y. Lu (CAMH: Centre for Addiction and Mental Health)H-Index: 1
Last. Herbert Y. Meltzer (NU: Northwestern University)H-Index: 128
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#1Danai Dima (City University London)H-Index: 20
#2Efstathios Papachristou (UCL: University College London)H-Index: 9
Last. Kathryn I. AlpertH-Index: 11
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Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalised on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine the age-related morphometric trajectories of the ventric...
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#1Sophia Frangou (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 62
#2Amirhossein Modabbernia (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 23
Last. Dag Alnæs (University of Oslo)H-Index: 18
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Delineating age-related cortical trajectories in healthy individuals is critical given the association of cortical thickness with cognition and behaviour. Previous research has shown that deriving robust estimates of age-related brain morphometric changes requires large-scale studies. In response, we conducted a large-scale analysis of cortical thickness in 17,075 individuals aged 3-90 years by pooling data through the Lifespan Working group of the Enhancing Neuroimaging Genetics through Meta-An...
1 CitationsSource
#1Theo G.M. van ErpH-Index: 50
#2Ross A. BakerH-Index: 19
Last. Steven G. PotkinH-Index: 83
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#1Laurena HolleranH-Index: 7
#2Sinead KellyH-Index: 14
Last. Vaughan J. CarrH-Index: 59
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Objective:Schizophrenia has recently been associated with widespread white matter microstructural abnormalities, but the functional effects of these abnormalities remain unclear. Widespread heterog...
1 CitationsSource
#1Thomas P. Deramus (Georgia Institute of Technology)H-Index: 1
#2Rogers F. Silva (Georgia Institute of Technology)H-Index: 9
Last. Godfrey D. Pearlson (Yale University)H-Index: 110
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The human brain is asymmetrically lateralized for certain functions (such as language processing) to regions in one hemisphere relative to the other. Asymmetries are measured with a laterality index (LI). However, traditional LI measures are limited by a lack of consensus on metrics used for its calculation. To address this limitation, source-based laterality (SBL) leverages an independent component analysis for the identification of laterality-specific alterations, identifying covarying compone...
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OBJECTIVE: To assess the antipsychotic efficacy and safety of a combination of olanzapine and samidorphan (OLZ/SAM). METHODS: This 4-week, phase 3, randomized, double-blind, placebo- and olanzapine-controlled study was conducted from December 2015 to June 2017 in adults with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria who were experiencing an acute exacerbation. Patients were randomized 1:1:1 to OLZ/SAM, olanzapine monother...
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#1Steven G. Potkin (UCI: University of California, Irvine)H-Index: 83
#2John M. Kane (Hofstra University)H-Index: 105
Last. Oliver D. Howes (Imperial College London)H-Index: 52
view all 8 authors...
Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms despite ≥2 trials of adequate dose and duration of antipsychotic medication with documented adherence, is a serious clinical problem with heterogeneous presentations. TRS can vary in its onset (at the first episode of psychosis or upon relapse), in its severity, and in the response to subsequent therapeutic interventions (i.e., clozapine, electroconvulsive therapy). The heterogeneity of TRS indicates that the underlyin...
2 CitationsSource
Objective: Multimodal measurements of the same phenomena provide complementary information and highlight different perspectives, albeit each with their own limitations. A focus on a single modality may lead to incorrect inferences, which is especially important when a studied phenomenon is a disease. In this paper, we introduce a method that takes advantage of multimodal data in addressing the hypotheses of disconnectivity and dysfunction within schizophrenia (SZ). Methods: We start with estimat...
1 CitationsSource
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