Montserrat G. Vásquez-Valdivieso
University of Edinburgh
Publications 28
#1Meng YuanH-Index: 3
#2Montserrat G. Vásquez-Valdivieso (Edin.: University of Edinburgh)H-Index: 2
Last.Malcolm D. WalkinshawH-Index: 50
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Abstract The gluconeogenic enzyme fructose-1,6-bisphosphatase has been proposed as a potential drug target against Leishmania parasites that cause up to 20,000–30,000 deaths annually. A comparison of three crystal structures of Leishmania major fructose-1,6-bisphosphatase ( Lm FBPase) along with enzyme kinetic data show how AMP acts as an allosteric inhibitor and provides insight into its metal-dependent reaction mechanism. The crystal structure of the apoenzyme form of Lm FBPase is a homotetram...
#1Kyle R. Brimacombe (NIH: National Institutes of Health)H-Index: 17
#2Martin J. Walsh (NIH: National Institutes of Health)H-Index: 33
Last.Matthew B. Boxer (NIH: National Institutes of Health)H-Index: 22
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Human African Trypanosomiasis (HAT) is a severe, often fatal disease caused by the parasitic protist Trypanosoma brucei. The glycolytic pathway has been identified as the sole mechanism for ATP generation in the infective stage of these organisms, and several glycolytic enzymes, phosphofructokinase (PFK) in particular, have shown promise as potential drug targets. Herein, we describe the discovery of ML251, a novel nanomolar inhibitor of T. brucei PFK, and the structure–activity relationships wi...
#1Martin J. WalshH-Index: 33
#2Kyle R. BrimacombeH-Index: 1
Last.Matthew B. BoxerH-Index: 22
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