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Massimo Loda
Harvard University
546Publications
101H-index
44.9kCitations
Publications 546
Newest
#1David P. Labbé (Harvard University)H-Index: 4
#2Giorgia Zadra (Harvard University)H-Index: 16
Last.Myles Brown (Harvard University)H-Index: 91
view all 34 authors...
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer model, that high-fat diet (HFD) enhances the MYC transcriptional program through metabolic alterations that favour histone H4K20 hypomethylation at the promoter regions of MYC regulated genes, leading ...
#1Sheheryar Kabraji (Harvard University)H-Index: 6
Last.Sridhar Ramaswamy (Harvard University)H-Index: 56
view all 7 authors...
Ductal carcinoma in situ (DCIS) of the breast precedes the development of invasive breast cancer and reflects the genomic changes and protein expression profile of invasive disease. AKT1low cancer cells (QCC) are a rare, drug-tolerant, epigenetically plastic, and quiescent cancer cell subset that we previously identified at a frequency of 0.5–1% in primary breast tumors using the marker profile: AKTlow/H3K9me2low/HES1high. Here we used quantitative immunofluorescence microscopy with computationa...
#1Mariano J. Alvarez (Columbia University)H-Index: 23
#2Pengrong Yan (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 17
Last.Andrea CalifanoH-Index: 60
view all 21 authors...
#1Yiwen Zhang (Harvard University)
#2Cindy Ke Zhou (Harvard University)H-Index: 1
Last.Ericka M. Ebot (Harvard University)H-Index: 5
view all 12 authors...
Background: Inflammation and focal atrophy are common features adjacent to prostate tumors. Limited evidence exists on whether these features have prognostic significance. Methods: In the Health Professionals Follow-Up Study and Physicians9 Health Study, we studied 1,035 men diagnosed with prostate cancer. A genitourinary pathologist centrally reviewed tumor and normal areas of hematoxylin and eosin slides from prostate cancer specimens for the presence of acute and chronic inflammation, and fou...
#1Anis Hamid (Harvard University)H-Index: 2
#2Kathryn J. Gray (Harvard University)H-Index: 16
Last.Christopher Sweeney (Harvard University)H-Index: 57
view all 7 authors...
Abstract Background PTEN deletion is associated with relapse after therapy for localized prostate cancer. There are limited data on PTEN loss as detected by immunohistochemistry (IHC) and the risk of lethal disease after surgery. Objective To determine whether PTEN loss as detected by quantitative fluorescence IHC (FIHC) predicts lethal disease outcomes after surgery for prostate cancer. Design, setting and participants We used formalin-fixed, paraffin-embedded radical prostatectomy specimens to...
#1Anjali V. Sheahan (Harvard University)H-Index: 3
#2Katherine L. Morel (Harvard University)H-Index: 4
Last.Leigh Ellis (Broad Institute)H-Index: 16
view all 23 authors...
Prostate cancers are considered immunologically cold tumors given the very few patients who respond to checkpoint inhibitor therapy (CPI). Recently, enrichment of interferon (IFN) response genes predicts a favorable response to CPI across various disease sites. The enhancer of zeste homolog-2 (EZH2) is over-expressed in prostate cancer and is known to negatively regulate IFN response genes. Here, we demonstrate that inhibition of EZH2 catalytic activity in prostate cancer models derepresses expr...
#1Himisha Beltran (Harvard University)H-Index: 40
#2Andrew M. Hruszkewycz (NIH: National Institutes of Health)H-Index: 6
Last.Peter S. Nelson (Fred Hutchinson Cancer Research Center)H-Index: 76
view all 32 authors...
Lineage plasticity has emerged as an important mechanism of treatment resistance in prostate cancer (PC). Treatment refractory PCs are increasingly associated with loss of luminal prostate markers, and in many cases induction of developmental programs, stem cell-like phenotypes, and neuroendocrine/neuronal features. Clinically, lineage plasticity may manifest as low prostate specific antigen (PSA) progression, resistance to AR pathway inhibitors, and sometimes small cell/neuroendocrine pathologi...
#1Dana Hashim (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 6
#2Amparo G. Gonzalez-Feliciano (Harvard University)H-Index: 3
Last.Rebecca E. Graff (Harvard University)H-Index: 11
view all 17 authors...
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