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Yoshihiro Kawaoka
University of Tokyo
789Publications
120H-index
55.8kCitations
Publications 763
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Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets. Re...
1 CitationsSource
ABSTRACT Influenza virus relies heavily on cellular machinery to replicate in host cells. Therefore, to better understand the influenza virus life cycle, it is important to identify which host proteins are involved and how they function in virus replication. Previously, we identified G protein pathway suppressor 1 (GPS1) to be a matrix protein 2 (M2)-interacting host protein. GPS1 is a component of the COP9 signalosome, which regulates the NF-κB signaling pathway. Here, we found that the downreg...
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#1Tokiko Watanabe (UTokyo: University of Tokyo)H-Index: 7
#2Nobuhiro Suzuki (UTokyo: University of Tokyo)H-Index: 62
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
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Abstract Given that approximately 1031 virus particles exist on Earth and all of them are parasitic in living organisms, it is not hard to imagine how virus infection might affect the physiology of hosts and their ecosystems. However, traditional virology research tends to focus on viral pathogenicity or the individual pathogenic viruses; hence, the significance of viruses and viral-mediated processes in the global ecosystem has been poorly understood. To identify the previously unrecognized “ra...
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#1Kazuhito Tabata (UTokyo: University of Tokyo)H-Index: 1
#2Yoshihiro Minagawa (UTokyo: University of Tokyo)H-Index: 5
Last.Hiroyuki Noji (UTokyo: University of Tokyo)H-Index: 47
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There is large demand for a quantitative method for rapid and ultra-sensitive detection of the influenza virus. Here, we established a digital influenza virus counting (DIViC) method that can detect a single virion without antibody. In the assay, a virion is stochastically entrapped inside a femtoliter reactor array device for the fluorogenic assay of neuraminidase, and incubated for minutes. By analyzing 600,000 reactors, the practical limit of detection reached the order of 103 (PFU)/mL, only ...
1 CitationsSource
Viral neuraminidase inhibitors show limited efficacy in mice infected with H7N9 influenza A viruses isolated from humans. Although baloxavir marboxil protected mice from lethal challenge infection with a low pathogenic avian influenza H7N9 virus isolated from a human, its efficacy in mice infected with a recent highly pathogenic version of H7N9 human isolates is unknown. Here, we examined the efficacy of baloxavir marboxil in mice infected with a highly pathogenic human H7N9 virus, A/Guangdong/1...
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#1Li Wu (UTokyo: University of Tokyo)
#2Hiromichi Mitake (UTokyo: University of Tokyo)H-Index: 1
Last.Yoshihiro Kawaoka (UTokyo: University of Tokyo)H-Index: 120
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#1Masahiko Arikata (Shiga University of Medical Science)H-Index: 7
#2Yasushi Itoh (Shiga University of Medical Science)H-Index: 20
Last.Takeshi Shimizu (Shiga University of Medical Science)H-Index: 25
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Abstract Clarithromycin (CAM), a 14-membered ring macrolide, has anti-inflammatory and immunomodulatory actions and antiviral effects in seasonal influenza virus infection. We examined the prophylactic and therapeutic efficacy of CAM against H5N1 highly pathogenic and H7N9 low pathogenic avian influenza virus infections in cynomolgus monkeys. CAM suppressed H5N1 virus-induced severe signs of disease in the treated monkeys and inhibited virus propagation in tracheal samples and the production of ...
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#1Joseph Eiden (Pfizer)H-Index: 16
Last.Pamuk BilselH-Index: 4
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