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Jelena Brkljacic
University of Zagreb
30Publications
8H-index
208Citations
Publications 30
Newest
#1Martina Pauk (University of Zagreb)H-Index: 3
#2Tatjana Bordukalo-Niksic (University of Zagreb)H-Index: 9
Last.Slobodan Vukicevic (University of Zagreb)H-Index: 47
view all 9 authors...
Aims Bone morphogenetic proteins (BMPs) are involved in the development and homeostasis of multiple organs and tissues. There has been a significant focus on understanding the role of BMPs in pancreatic β-cell dysfunction associated with type 2 diabetes (T2D). Our objective was to investigate the relationship between BMP6 and glucose homeostasis.
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#1Lovorka Grgurevic (University of Zagreb)H-Index: 17
#2Igor Erjavec (University of Zagreb)H-Index: 9
Last.Slobodan Vukicevic (University of Zagreb)H-Index: 47
view all 16 authors...
AbstractLiver fibrosis is a progressive pathological process resulting in an accumulation of excess extracellular matrix proteins. We discovered that bone morphogenetic protein 1-3 (BMP1-3), an isoform of the metalloproteinase Bmp1 gene, circulates in the plasma of healthy volunteers and its neutralization decreases the progression of chronic kidney disease in 5/6 nephrectomized rats. Here, we investigated the potential role of BMP1-3 in a chronic liver disease. Rats with carbon tetrachloride (C...
2 CitationsSource
#1Igor Erjavec (University of Zagreb)H-Index: 9
#2Tatjana Bordukalo-Niksic (University of Zagreb)H-Index: 9
Last.Slobodan Vukicevic (University of Zagreb)H-Index: 47
view all 13 authors...
Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption. The role of 5HT in bone therefore remains poorly understood. To address this issue, we used selective breeding to create rat sublines with constitutively high (high-5HT) and low (low-5HT) platelet 5H...
9 CitationsSource
#1Igor Erjavec (University of Zagreb)H-Index: 9
#2Jelena Brkljacic (University of Zagreb)H-Index: 8
Last.Ivan JakopovichH-Index: 2
view all 5 authors...
1 CitationsSource
#1Ivo Dumić-ČuleH-Index: 8
#2Dunja RogićH-Index: 9
Last.Slobodan VukicevicH-Index: 47
view all 6 authors...
1 Laboratory for Mineralized Tissues, Center for Translational and Clinical Research, School of Medicine 2 Clinical Institute of Laboratory Diagnosis, School of Medicine contact: ivodc1@gmail.com MATHERIALS AND METHODS Animals: Removal of thyroid and parathyroid glands was done by a ventral approach under the influence of rompun (Xylapan 0,6 ml/kg i.p.) and ketamine (Narketan 0,8 ml/kg i.p.) anesthesia. Biochemical serum parameters: blood was collected at various time points by retroorbital blee...
#1Martina Pauk (University of Zagreb)H-Index: 3
#2Lovorka Grgurevic (University of Zagreb)H-Index: 17
Last.Slobodan Vukicevic (University of Zagreb)H-Index: 47
view all 14 authors...
Purpose Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene. We investigated involvement of other BMPs in preventing haemochromatosis and subsequent osteopenia in Bmp6-/- mice.
20 CitationsSource
#1Lovorka GrgurevicH-Index: 17
#2Marko PećinaH-Index: 3
Last.Slobodan VukicevicH-Index: 47
view all 6 authors...
#1Ivo Dumić-Čule (University of Zagreb)H-Index: 8
#2Jelena Brkljacic (University of Zagreb)H-Index: 8
Last.Slobodan Vukicevic (University of Zagreb)H-Index: 47
view all 10 authors...
Purpose Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone administration might affect skeletal metabolism. To answer this question, we examined effects of systemically administered BMP-2 and -7 on bone in a newly developed rat model with a low level of calciotropic hormones.
9 CitationsSource
#2Igor ErjavecH-Index: 9
Last.Slobodan VukicevicH-Index: 47
view all 8 authors...
#1Igor ErjavecH-Index: 9
Last.Slobodan VukicevicH-Index: 47
view all 14 authors...
To further characterize the role of serotonin (5HT) in bone metabolism, Wistar-Zagreb rat model consisting of the high-5HT and low-5HT subline with different platelet 5HT content and transporter (5HTT) activity has been used. Primary osteoclasts from the high-5HT subline had an increased expression of 5HTT, 5HT–2A receptor, Trap and cathepsin K, while osteoblasts showed no difference in the expression of 5HT elements or osteoblastic markers. However, upon addition of 5HT and insulin combination,...
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