Magdalena K. Poplutz
RWTH Aachen University
Regulation of gene expressionDNA methylationHistone methylationTrichostatin ABiology
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Publications 3
#1Magdalena K. Poplutz (RWTH Aachen University)H-Index: 2
#2Maryna Levikova (UZH: University of Zurich)H-Index: 7
Last. Michael Huber (RWTH Aachen University)H-Index: 14
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Stimulation with lipopolysaccharide (LPS; endotoxin) not only causes rapid production of proinflammatory cytokines, but also induces a state of LPS hypo-responsiveness to a second LPS stimulation (endotoxin tolerance (ET)). Murine bone marrow-derived MCs (BMMCs) and peritoneal MCs (PMCs) developed ET as shown by an abrogated production of Il6/Tnf RNAs and IL-6/TNF-α proteins. In naive BMMCs, LPS stimulation induced a transient decline in the trimethylation of lysine 9 of the core histone H3 (H3K...
3 CitationsSource
#2Bernhard LüscherH-Index: 60
Last. Michael HuberH-Index: 14
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#1Magdalena K. Poplutz (RWTH Aachen University)H-Index: 2
#2Inga Wessels (RWTH Aachen University)H-Index: 7
Last. Peter Uciechowski (RWTH Aachen University)H-Index: 19
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Abstract The pro-inflammatory cytokine Interleukin (IL)-6 is involved in the proliferation and differentiation of leukocytes and non-immune cells, but its overproduction is associated with inflammatory and autoimmune disorders. The main producers of IL-6 are mature monocytes, whereas progenitor cells and the promyeloid cell line HL-60 do not synthesize IL-6. In contrast, HL-60 cells differentiated into monocytic cells were able to express IL-6 after lipopolysaccharide (LPS) stimulation. This stu...
20 CitationsSource