Martin S. Obin
Tufts University
EndocrinologyAdipose tissueAdipocyteBiochemistryBiology
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Publications 79
#1Erin D. Lewis (Tufts University)H-Index: 3
#2Zhihong Ren (Tufts University)H-Index: 12
Last. Dayong Wu (Tufts University)H-Index: 35
view all 6 authors...
Blueberry, rich in antioxidant and anti-inflammatory phytochemicals, has been demonstrated to lower inflammatory status in adipose induced by high-fat diet (HFD) and obesity. The effect of blueberry on systemic immune functions has not been examined. C57BL/6 mice were randomised to one of three diets – low-fat diet (LFD), HFD and HFD plus 4 % (w/w) blueberry (HFD+B) – for 8 or 12 weeks. Ex vivo T-cell mitogens (concanavalin A (Con A); phytohaemagglutinin), T-cell antibody (anti-CD3; anti-CD3/CD2...
3 CitationsSource
#1Beverly S. Rubin (Tufts University)H-Index: 39
#2Maneesha Paranjpe (Tufts University)H-Index: 2
Last. Andrew S. Greenberg (Tufts University)H-Index: 68
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Abstract Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250 μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body c...
24 CitationsSource
#1Caleigh M. SawickiH-Index: 2
#2Kara A. LivingstonH-Index: 3
Last. Nicola M. McKeownH-Index: 36
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Interest is rapidly growing around the role of the human gut microbiota in facilitating beneficial health effects associated with consumption of dietary fiber. An evidence map of current research activity in this area was created using a newly developed database of dietary fiber intervention studies in humans to identify studies with the following broad outcomes: (1) modulation of colonic microflora; and/or (2) colonic fermentation/short-chain fatty acid concentration. Study design characteristi...
36 CitationsSource
#1Christopher Cotton (Tufts University)
#2Kenneth Westerman (Tufts University)H-Index: 3
Last. Martin S. Obin (Tufts University)H-Index: 38
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#1Anna C. Pfalzer (Tufts University)H-Index: 5
#2Paula-Dene Nesbeth (Tufts University)H-Index: 2
Last. Jimmy W. Crott (Tufts University)H-Index: 20
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Obesity is a risk factor for colorectal cancer (CRC), and alterations in the colonic microbiome and metabolome may be mechanistically involved in this relationship. The relative contribution of diet and obesity per se are unclear. We compared the effect of diet- and genetically-induced obesity on the intestinal microbiome and metabolome in a mouse model of CRC. Apc1638N mice were made obese by either high fat (HF) feeding or the presence of the Leprdb/db (DbDb) mutation. Intestinal tumors were q...
19 CitationsSource
#1Caleigh M. Sawicki (Tufts University)H-Index: 2
#2Kara A. Livingston (Tufts University)H-Index: 3
Last. Nicola M. McKeown (Tufts University)H-Index: 36
view all 6 authors...
1 Citations
#1Frederick K. Kamanu (Tufts University)H-Index: 1
#2Estelle Zirkler (Tufts University)
Last. Caren E. Smith (Tufts University)H-Index: 23
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Chronic inflammation is often a major contributor to the onset and progression of cardiometabolic dysfunction. Whether through effects on the inflammatory response system or independent of inflammation, plant-derived polyphenols comprise a micro-nutrient class important in cardiovascular disease and other cardiometabolic traits. Well-known effects of these compounds include reducing blood glucose, acting as a diuretic, and raising HDL cholesterol. Using a computational approach, published phytoc...
#1Jingjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Huang Tang (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Jian Shen (SJTU: Shanghai Jiao Tong University)H-Index: 9
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Structural disruption of gut microbiota and associated inflammation are considered important etiological factors in high fat diet (HFD)-induced metabolic syndrome (MS). Three candidate probiotic strains, Lactobacillus paracasei CNCM I-4270 (LC), L. rhamnosus I-3690 (LR) and Bifidobacterium animalis subsp. lactis I-2494 (BA), were individually administered to HFD-fed mice (108 cells day−1) for 12 weeks. Each strain attenuated weight gain and macrophage infiltration into epididymal adipose tissue ...
354 CitationsSource
#1Grace Bennett (Tufts University)H-Index: 6
#2Katherine J. Strissel (Tufts University)H-Index: 28
Last. Martin S. Obin (Tufts University)H-Index: 38
view all 7 authors...
Objective To investigate the role of TNF-like weak inducer of apoptosis (TWEAK) in pathological adipose tissue (AT) remodeling and complications of obesity. Methods Wild type (WT) and TWEAK knockout (KO) mice were fed normal diet (ND) or a high fat diet (HFD) for up to 17 weeks. Adipocyte death was induced using an established transgenic mouse model of inducible adipocyte apoptosis (FAT-ATTAC). Metabolic, biochemical, histologic, and flow cytometric analyses were performed. Results TWEAK and its...
6 CitationsSource
#1Nicole L. Spartano (Tufts University)H-Index: 7
#2Stefania Lamon-Fava (Tufts University)H-Index: 29
Last. Alice H. Lichtenstein (Tufts University)H-Index: 81
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Individuals with type 2 diabetes mellitus are at increased risk of developing atherosclerosis. This may be partially attributable to suppression of macrophage ATP-binding cassette (ABC) transporter mediated cholesterol efflux by sustained elevated blood glucose concentrations. 2 models were used to assess this potential relationship: human monocytes/leukocytes and murine bone marrow-derived macrophages (BMDM). 10 subjects (4 F/6 M, 50–85 years, BMI 25–35 kg/m²) underwent an oral glucose challeng...
5 CitationsSource