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Hardev Pandha
University of Surrey
402Publications
46H-index
7,116Citations
Publications 397
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#1Kate Relph (University of Surrey)H-Index: 8
#2Nicola E. Annels (University of Surrey)H-Index: 23
Last.Hardev Pandha (University of Surrey)H-Index: 46
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#1Natasha Punia (University of Surrey)H-Index: 1
#2Monika Primon (University of Bradford)H-Index: 1
Last.Richard Morgan (University of Bradford)H-Index: 25
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Engrailed-2 (EN2) is a homeodomain-containing transcription factor that has roles in boundary formation and neural guidance in early development, but which is also expressed in a range of cancers. In addition to transcriptional regulation, it is secreted by cells and taken up by others through a mechanism that is yet to be fully elucidated. In this study, the distribution of EN2 protein in cells was evaluated using immunofluorescence with a set of antibodies raised against overlapping epitopes a...
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#1Marco Matejcic (SC: University of Southern California)H-Index: 1
#2Ed Saunders (ICR: Institute of Cancer Research)H-Index: 23
Last.Christopher A. Haiman (SC: University of Southern California)H-Index: 82
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Correction to: Nature Communications; https://doi.org/10.1038/s41467-018-06863-1, published online 5 November 2018. The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Hilary K. Finucane (Broad Institute)H-Index: 29
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
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#1Louise M. E. Müller (St James's University Hospital)H-Index: 1
#2Matthew Holmes (St James's University Hospital)H-Index: 1
Last.Fiona Errington-Mais (St James's University Hospital)H-Index: 12
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The oncolytic virus, coxsackievirus A21 (CVA21), has shown promise as a single agent in several clinical trials and is now being tested in combination with immune checkpoint blockade. Combination therapies offer the best chance of disease control; however, the design of successful combination strategies requires a deeper understanding of the mechanisms underpinning CVA21 efficacy, in particular, the role of CVA21 anti-tumor immunity. Therefore, this study aimed to examine the ability of CVA21 to...
1 CitationsSource
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Hilary K. Finucane (Broad Institute)H-Index: 29
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Hilary K. Finucane (Broad Institute)H-Index: 29
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
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Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
9 CitationsSource
#1Nicola E. Annels (University of Surrey)H-Index: 23
#2David MansfieldH-Index: 9
Last.Hardev Pandha (University of Surrey)H-Index: 46
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Purpose: The CANON [CAVATAK in NON–muscle-invasive bladder cancer (NMIBC)] study evaluated a novel ICAM-1–targeted immunotherapeutic-coxsackievirus A21 as a novel oncolytic agent against bladder cancer. Patients and Methods: Fifteen patients enrolled in this “window of opportunity” phase I study, exposing primary bladder cancers to CAVATAK prior to surgery. The first 9 patients received intravesical administration of monotherapy CAVATAK; in the second stage, 6 patients received CAVATAK with a su...
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#1Shea P. Connell (UEA: University of East Anglia)H-Index: 6
#2Marcelino Yazbek-Hanna (UEA: University of East Anglia)H-Index: 1
Last.Jeremy Clark (UEA: University of East Anglia)H-Index: 45
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Objectives To develop a risk classifier using urine‐derived extracellular vesicle (EV)‐RNA capable of providing diagnostic information on disease status prior to biopsy, and prognostic information for men on active surveillance (AS). Patients and Methods Post‐digital rectal examination urine‐derived EV‐RNA expression profiles (n = 535, multiple centres) were interrogated with a curated NanoString panel. A LASSO‐based continuation ratio model was built to generate four prostate urine risk (PUR) s...
3 CitationsSource
#1Xia JiangH-Index: 6
#2Hilary K. FinucaneH-Index: 29
Last.Sara LindstroemH-Index: 46
view all 333 authors...
textabstractAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
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