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Laura G. Sánchez-Lozada
University of Colorado Denver
104Publications
37H-index
5,665Citations
Publications 104
Newest
Abstract Recently repeated heat stress and dehydration have been reported to cause oxidative stress and kidney damage that is enhanced by rehydrating with fructose solutions. We hypothesized that antioxidants might provide a novel way to prevent kidney damage. To test this hypothesis, mild heat stress was induced by exposing rats to 37 °C during 1 h in a closed chamber. The supplementation with water-soluble antioxidants (Antiox), ascorbic acid 1% plus N-acetyl cysteine 600 mg/L was done either ...
#2Edilia TapiaH-Index: 34
Last.Laura G. Sánchez-LozadaH-Index: 37
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Ischemia-reperfusion injury of the kidney may lead to renal fibrosis through a combination of several mechanisms. We recently demonstrated that fasting protects the rat kidney against oxidative stress and mitochondrial dysfunction in early acute kidney injury, and also against fibrosis development. Here we show that preoperative fasting preserves redox status and mitochondrial homeostasis at the chronic phase of damage after severe ischemia. Also, the protective effect of fasting coincides with ...
#1Pedro Rojas-Morales (UNAM: National Autonomous University of Mexico)H-Index: 1
Last.Diana Barrera-Oviedo (UNAM: National Autonomous University of Mexico)H-Index: 6
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Abstract Food deprivation protects against ischemia-reperfusion (IR) injury through unknown mechanisms. In an experimental rat model of acute IR injury, we found that preoperative fasting for 3 days protects rats from tubular damage and renal functional decline by increasing antioxidant protection independently of the NF-E2-related factor 2 (Nrf2), and by maintaining mitochondrial morphology and function. In addition, further analysis revealed that fasting protects against tubulointerstitial fib...
#1Omar Emiliano Aparicio-Trejo (UNAM: National Autonomous University of Mexico)H-Index: 5
#2Laura María Reyes-Fermín (UNAM: National Autonomous University of Mexico)H-Index: 3
Last.José Pedraza-Chaverri (UNAM: National Autonomous University of Mexico)H-Index: 48
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Abstract Folic acid (FA)-induced acute kidney injury (AKI) is a widely used model for studies of the renal damage and its progression to chronic state. However, the molecular mechanisms by which FA induces AKI remain poorly understood. Since renal function depends on mitochondrial homeostasis, it has been suggested that mitochondrial alterations contribute to AKI development. Additionally, N-acetyl-cysteine (NAC) can be a protective agent to prevent mitochondrial and renal dysfunction in this mo...
#1Tamara Milagres (Anschutz Medical Campus)H-Index: 8
Last.Jason GlaserH-Index: 9
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Background Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have recently reported a model of CKD induced by heat stress. Here we test the hypothesis that rehydration with fructose may induce worse kidney injury than rehydration with equal amounts of water, and we also test if this fructose-induced injury is associated with activation of inflam...
#1Richard J. Johnson (Anschutz Medical Campus)H-Index: 115
Last.Thomas Jensen (University of Colorado Denver)H-Index: 15
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Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation. We analyzed a previously published randomized controlled study that included 33 healthy male adults (40–65 years of age) who ingested 200 g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks. Participants were ...
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