Laura G. Sánchez-Lozada
University of Colorado Denver
EndocrinologyFructoseUric acidDiabetes mellitusMedicine
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Publications 119
#1Masanari KuwabaraH-Index: 12
#2Mehmet KanbayH-Index: 39
Last. Ichiro HisatomeH-Index: 37
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The potential contribution of serum osmolarity in the modulation of blood pressure has not been evaluated. This study was done to examine the relationship between hyperosmolarity and hypertension in a five-year longitudinal design. We enrolled 10,157 normotensive subjects without diabetes who developed hypertension subsequently as determined by annual medical examination in St. Luke’s International Hospital, Tokyo, between 2004 and 2009. High salt intake was defined as >12 g/day by a self-answer...
#1Pedro Rojas-Morales (UNAM: National Autonomous University of Mexico)H-Index: 2
Last. Edilia TapiaH-Index: 35
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Abstract Food restriction improves metabolic health and increases resistance to stress in experimental animals. However, most studies have focused on long-term dietary restriction protocols consisting of several weeks or months of limited food ingestion. Here it was investigated the impact of 2-h time-restricted feeding (TRF) for one week on stress resistance in a rat model of kidney injury induced by ischemia and reperfusion. At baseline, TRF reduced blood glucose, increased β-hydroxybutyrate a...
#1Takahiko Nakagawa (Shiga University of Medical Science)H-Index: 32
#2Richard J. Johnson (University of Colorado Denver)H-Index: 118
Last. Miguel A. Lanaspa (University of Colorado Denver)H-Index: 35
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Understanding fructose metabolism might provide insights to renal pathophysiology. To support systemic glucose concentration, the proximal tubular cells reabsorb fructose as a substrate for gluconeogenesis. However, in instances when fructose intake is excessive, fructose metabolism is costly, resulting in energy depletion, uric acid generation, inflammation, and fibrosis in the kidney. A recent scientific advance is the discovery that fructose can be endogenously produced from glucose under pat...
Last. Petter Bjornstad (CU: University of Colorado Boulder)H-Index: 16
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The association between increased serum urate and hypertension has been a subject of intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones, and possibly vascular calcification. Mendelian randomization studies, however, indicate that serum urate is likely not the causal factor in hypertension although it does increase the risk for sudden cardiac death and diabetic vascular disease. Nevertheless, experimental evidence strongly suggests that an increase in ...
#1Richard J. Johnson (Anschutz Medical Campus)H-Index: 118
#2Peter StenvinkelH-Index: 85
Last. Miguel A. Lanaspa (Anschutz Medical Campus)H-Index: 35
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Mass extinctions occur frequently in natural history. While studies of animals that became extinct can be informative, it is the survivors that provide clues for mechanisms of adaptation when conditions are adverse. Here, we describe a survival pathway used by many species as a means for providing adequate fuel and water, while also providing protection from a decrease in oxygen availability. Fructose, whether supplied in the diet (primarily fruits and honey), or endogenously (via activation of ...
2 CitationsSource
#1Shuchi Anand (Stanford University)H-Index: 15
#2Ben Caplin (UCL: University College London)H-Index: 12
Last. Karen YeatesH-Index: 24
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5 CitationsSource
#1Mehmet Kanbay (Koç University)H-Index: 7
#2Sezen Yılmaz (Koç University)
Last. Baris Afsar (Süleyman Demirel University)H-Index: 19
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#1Yuka Sato (CU: University of Colorado Boulder)H-Index: 8
#2Carlos A. Roncal-Jimenez (CU: University of Colorado Boulder)H-Index: 9
Last. Richard J. Johnson (CU: University of Colorado Boulder)H-Index: 118
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An epidemic of chronic kidney disease of unknown etiology (Mesoamerican nephropathy) has emerged in hot regions of Central America. We have demonstrated that dehydration associated with recurrent h...
Abstract Recently repeated heat stress and dehydration have been reported to cause oxidative stress and kidney damage that is enhanced by rehydrating with fructose solutions. We hypothesized that antioxidants might provide a novel way to prevent kidney damage. To test this hypothesis, mild heat stress was induced by exposing rats to 37 °C during 1 h in a closed chamber. The supplementation with water-soluble antioxidants (Antiox), ascorbic acid 1% plus N-acetyl cysteine 600 mg/L was done either ...
3 CitationsSource