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Hidde L. Ploegh
Massachusetts Institute of Technology
658Publications
115H-index
49.3kCitations
Publications 658
Newest
Published on Feb 1, 2019
Ross W. Cheloha1
Estimated H-index: 1
,
Zeyang Li8
Estimated H-index: 8
+ 4 AuthorsHidde L. Ploegh115
Estimated H-index: 115
Source Cite
Published on Jan 1, 2019in Biomaterials Science 5.83
Yu-Sang Sabrina Yang5
Estimated H-index: 5
(Massachusetts Institute of Technology),
Kelly Dare Moynihan9
Estimated H-index: 9
(Massachusetts Institute of Technology)
+ 9 AuthorsHidde L. Ploegh115
Estimated H-index: 115
(Massachusetts Institute of Technology)
We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads of small molecule drugs within hydrophobic pockets of their ligand shells. These particles exhibit membrane-penetrating activity in mammalian cells, and thus enhanced uptake of a small molecule TGF-β inhibitor in T cells in cell culture. By co...
3 Citations Source Cite
Published on Dec 17, 2018in Nature Biotechnology 35.72
Young-Gyun Park5
Estimated H-index: 5
,
Chang Ho Sohn9
Estimated H-index: 9
+ 20 AuthorsWendy Trieu1
Estimated H-index: 1
Controlled tissue fixation with polyepoxides protects protein fluorescence, antigenicity, nucleic acids and tissue architecture.
4 Citations Source Cite
Published on Nov 1, 2018in iScience
Manpreet Kaur (Indian Institute of Science Education and Research, Mohali), Dhaneshwar Kumar (Indian Institute of Science Education and Research, Mohali)+ 5 AuthorsS. K. Sehrawat14
Estimated H-index: 14
(Indian Institute of Science Education and Research, Mohali)
Summary To gain insights into the molecular mechanisms and pathways involved in the activation of γ-herpesvirus (MHV68)-specific T cell receptor transnuclear (TN) CD8 + T cells, we performed a comprehensive transcriptomic analysis. Upon viral infection, we observed differential expression of several thousand transcripts encompassing various networks and pathways in activated TN cells compared with their naive counterparts. Activated cells highly upregulated galectin-3. We therefore explored the ...
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Published on Oct 19, 2018in ACS Chemical Biology 4.59
Soohyun Kwon3
Estimated H-index: 3
(University of Queensland),
Joao N. Duarte6
Estimated H-index: 6
(Massachusetts Institute of Technology)
+ 6 AuthorsHidde L. Ploegh115
Estimated H-index: 115
(Massachusetts Institute of Technology)
Many naturally occurring peptides have poor proteolytic stability, which limits their therapeutic applications. Cyclotides are plant-derived cyclic peptides that resist proteolysis due to their highly constrained structure, comprising a head-to-tail cyclic backbone and three disulfide bonds that form a cystine-knotted core. This structure makes them useful as scaffolds onto which peptide sequences (epitopes) can be grafted. In this study, VHH7, an alpaca-derived nanobody that targets murine clas...
2 Citations Source Cite
Published on Apr 11, 2018in Science Translational Medicine 16.71
Jordan A. Krall4
Estimated H-index: 4
(Massachusetts Institute of Technology),
Ferenc Reinhardt31
Estimated H-index: 31
(Massachusetts Institute of Technology)
+ 8 AuthorsStephanie K. Dougan25
Estimated H-index: 25
(Massachusetts Institute of Technology)
Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery. The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of the disease. Others have proposed that some aspect of surgical tumor resection triggers the outgrowth of otherwise-dormant metastases, leading to the synchronous pattern of relapse. Clinical data canno...
29 Citations Source Cite
Published on Mar 1, 2018in American Journal of Physiology-renal Physiology 3.16
Guohui Ren1
Estimated H-index: 1
(Rush University Medical Center),
Nicholas J. Tardi6
Estimated H-index: 6
(Rush University Medical Center)
+ 6 AuthorsJochen Reiser46
Estimated H-index: 46
(Rush University)
Podocytes are terminally differentiated cells of the kidney filtration barrier with a limited proliferative capacity, and are the primary glomerular target for various sources of cellular stress. Accordingly, it is particularly important for podocytes to cope with stress efficiently to circumvent cell death and avoid compromising renal function. Improperly folded proteins within the endoplasmic reticulum (ER) are associated with increased cellular injury and cell death. To relieve ER stress, pro...
2 Citations Source Cite
Published on Jan 1, 2018in Current Opinion in Immunology 7.93
Hidde L. Ploegh115
Estimated H-index: 115
Source Cite
Published on Dec 1, 2017in Nature Communications 12.35
Jessica R. Ingram17
Estimated H-index: 17
(Massachusetts Institute of Technology),
Michael Dougan14
Estimated H-index: 14
(Massachusetts Institute of Technology)
+ 12 AuthorsAtul K. Bhan87
Estimated H-index: 87
(Harvard University)
Programmed death ligand 1 (PD-L1) is expressed on a number of immune and cancer cells, where it can downregulate antitumor immune responses. Its expression has been linked to metabolic changes in these cells. Here we develop a radiolabeled camelid single-domain antibody (anti-PD-L1 VHH) to track PD-L1 expression by immuno-positron emission tomography (PET). PET-CT imaging shows a robust and specific PD-L1 signal in brown adipose tissue (BAT). We confirm expression of PD-L1 on brown adipocytes an...
8 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Jasdave S. Chahal6
Estimated H-index: 6
(Massachusetts Institute of Technology),
Tao Fang9
Estimated H-index: 9
(Massachusetts Institute of Technology)
+ 4 AuthorsHidde L. Ploegh115
Estimated H-index: 115
(Massachusetts Institute of Technology)
The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV’s neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particularly T cell responses, remain sparse. We deployed RNA nanoparticle technology to create a vaccine candidate that elicited ZIKV E protein-specific IgG responses in C57BL/6 mice as assa...
35 Citations Source Cite
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