Hidde L. Ploegh
Massachusetts Institute of Technology
642Publications
113H-index
47.6kCitations
Publications 642
Newest
Published on Jan 1, 2019in Biomaterials Science 5.83
Yu-Sang Sabrina Yang4
Estimated H-index: 4
(Massachusetts Institute of Technology),
Kelly Dare Moynihan9
Estimated H-index: 9
(Massachusetts Institute of Technology)
+ 9 AuthorsHidde L. Ploegh113
Estimated H-index: 113
(Massachusetts Institute of Technology)
We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads of small molecule drugs within hydrophobic pockets of their ligand shells. These particles exhibit membrane-penetrating activity in mammalian cells, and thus enhanced uptake of a small molecule TGF-β inhibitor in T cells in cell culture. By co...
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Published on Apr 11, 2018in Science Translational Medicine 16.71
Jordan A. Krall4
Estimated H-index: 4
(Massachusetts Institute of Technology),
Ferenc Reinhardt30
Estimated H-index: 30
(Massachusetts Institute of Technology)
+ 8 AuthorsStephanie K. Dougan24
Estimated H-index: 24
(Massachusetts Institute of Technology)
Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery. The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of the disease. Others have proposed that some aspect of surgical tumor resection triggers the outgrowth of otherwise-dormant metastases, leading to the synchronous pattern of relapse. Clinical data canno...
22 Citations Source Cite
Published on Nov 1, 2018in iScience
Manpreet Kaur (Indian Institute of Science Education and Research, Mohali), Dhaneshwar Kumar1
Estimated H-index: 1
(Indian Institute of Science Education and Research, Mohali)
+ 5 AuthorsSharvan Sehrawat13
Estimated H-index: 13
(Indian Institute of Science Education and Research, Mohali)
Summary To gain insights into the molecular mechanisms and pathways involved in the activation of γ-herpesvirus (MHV68)-specific T cell receptor transnuclear (TN) CD8 + T cells, we performed a comprehensive transcriptomic analysis. Upon viral infection, we observed differential expression of several thousand transcripts encompassing various networks and pathways in activated TN cells compared with their naive counterparts. Activated cells highly upregulated galectin-3. We therefore explored the ...
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Matthias C. Truttmann11
Estimated H-index: 11
(Boston Children's Hospital),
David Pincus15
Estimated H-index: 15
(Massachusetts Institute of Technology),
Hidde L. Ploegh113
Estimated H-index: 113
(Boston Children's Hospital)
Proteostasis is critical to maintain organismal viability, a process counteracted by aging-dependent protein aggregation. Chaperones of the heat shock protein (HSP) family help control proteostasis by reducing the burden of unfolded proteins. They also oversee the formation of protein aggregates. Here, we explore how AMPylation, a posttranslational protein modification that has emerged as a powerful modulator of HSP70 activity, influences the dynamics of protein aggregation. We find that adjustm...
2 Citations Source Cite
Published on Jan 29, 2018in Frontiers in Immunology 5.51
Alexander Pichugin9
Estimated H-index: 9
,
Stasya Zarling5
Estimated H-index: 5
+ 3 AuthorsUrszula Krzych36
Estimated H-index: 36
2 Citations Source Cite
Published on Mar 1, 2018in American Journal of Physiology-renal Physiology 3.16
Guohui Ren (Rush University Medical Center), Nicholas J. Tardi6
Estimated H-index: 6
(Rush University Medical Center)
+ 6 AuthorsJochen Reiser45
Estimated H-index: 45
(Rush University)
Podocytes are terminally differentiated cells of the kidney filtration barrier with a limited proliferative capacity, and are the primary glomerular target for various sources of cellular stress. Accordingly, it is particularly important for podocytes to cope with stress efficiently to circumvent cell death and avoid compromising renal function. Improperly folded proteins within the endoplasmic reticulum (ER) are associated with increased cellular injury and cell death. To relieve ER stress, pro...
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Published on Jan 1, 2018in Current Opinion in Immunology 7.93
Hidde L. Ploegh113
Estimated H-index: 113
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Published on Oct 19, 2018in ACS Chemical Biology 4.59
Soohyun Kwon3
Estimated H-index: 3
(University of Queensland),
Joao N. Duarte6
Estimated H-index: 6
(Massachusetts Institute of Technology)
+ 6 AuthorsHidde L. Ploegh113
Estimated H-index: 113
(Massachusetts Institute of Technology)
Many naturally occurring peptides have poor proteolytic stability, which limits their therapeutic applications. Cyclotides are plant-derived cyclic peptides that resist proteolysis due to their highly constrained structure, comprising a head-to-tail cyclic backbone and three disulfide bonds that form a cystine-knotted core. This structure makes them useful as scaffolds onto which peptide sequences (epitopes) can be grafted. In this study, VHH7, an alpaca-derived nanobody that targets murine clas...
2 Citations Source Cite
Published on Dec 17, 2018in Nature Biotechnology 35.72
Young-Gyun Park5
Estimated H-index: 5
,
Chang Ho Sohn9
Estimated H-index: 9
+ 20 AuthorsWendy Trieu1
Estimated H-index: 1
Controlled tissue fixation with polyepoxides protects protein fluorescence, antigenicity, nucleic acids and tissue architecture.
3 Citations Source Cite
Published on Jan 1, 2017in Chemical Science 9.06
Tao Fang9
Estimated H-index: 9
(Massachusetts Institute of Technology),
Catharina H. M. J. Van Elssen1
Estimated H-index: 1
(Massachusetts Institute of Technology)
+ 4 AuthorsHidde L. Ploegh113
Estimated H-index: 113
(Massachusetts Institute of Technology)
Unusual patterns of glycosylation on the surface of transformed cells contribute to immune modulation and metastasis of malignant tumors. Active immunization against them requires effective antigen presentation, which is complicated by a lack of access to tumor-specific posttranslational modifications through standard genetic approaches and by the low efficiency of passive antigen sampling. We found that antigen targeted to antigen presenting cells via class II MHC products can elicit a robust i...
3 Citations Source Cite
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