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Karl J. Kaiyala
University of Washington
EndocrinologyInsulinLeptinDiabetes mellitusBiology
64Publications
20H-index
2,110Citations
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Publications 65
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Physiological regulation is so fundamental to survival that natural selection has greatly favored the evolution of robust regulatory systems that use both reactive and preemptive responses to mitigate the disruptive impact of biological and environmental challenges on physiological function. In good health, robust regulatory systems provide little insight into the typically hidden complex array of sensor-effector interactions that accomplish successful regulation. Numerous health disorders have ...
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#1Karl J. Kaiyala (UW: University of Washington)H-Index: 20
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#1Jarrad M. Scarlett (UW: University of Washington)H-Index: 9
#2Kenjiro Muta (UW: University of Washington)H-Index: 4
Last. Michael W. Schwartz (UW: University of Washington)H-Index: 106
view all 17 authors...
We recently reported that in rodent models of type 2 diabetes (T2D), a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces remission of hyperglycemia that is sustained for weeks. To clarify the peripheral mechanisms underlying this effect, we used the Zucker diabetic fatty fa/fa rat model of T2D, which, like human T2D, is characterized by progressive deterioration of pancreatic β-cell function after hyperglycemia onset. We report that although icv FGF1 inj...
7 CitationsSource
#1Karl J. Kaiyala (UW: University of Washington)H-Index: 20
#2Brent E. Wisse (UW: University of Washington)H-Index: 25
Last. John R. B. LightonH-Index: 35
view all 3 authors...
Background Energy expenditure (EE) calculated from respirometric indirect calorimetry is most accurate when based on oxygen consumption (VO2), carbon dioxide production (VCO2) and estimated protein metabolism (PM). EE has a substantial dependence of ~7% on the respiratory quotient (RQ, VCO2/VO2) and a lesser dependence on PM, yet many studies have instead estimated EE from VO2 only while PM has often been ignored, thus reducing accuracy. In 1949 Weir proposed a method to accurately calculate EE ...
1 CitationsSource
#1Jennifer D. Deem (UW: University of Washington)H-Index: 5
#2Kenjiro Muta (UW: University of Washington)H-Index: 4
Last. Gregory J. Morton (UW: University of Washington)H-Index: 41
view all 7 authors...
The ability to maintain core temperature within a narrow range despite rapid and dramatic changes in environmental temperature is essential for the survival of free-living mammals, and growing evid...
3 CitationsSource
#1Salwa Al-Noori (UW: University of Washington)H-Index: 4
#2Andreas Cimpan (UW: University of Washington)H-Index: 1
Last. Douglas S. Ramsay (UW: University of Washington)H-Index: 22
view all 5 authors...
AbstractNitrous oxide (N2O) is a gaseous drug with abuse potential. Despite its common clinical use, little is known about whether N2O administration activates the HPA axis and/or the sympathetic adrenomedullary system. The goal of this study was to determine whether 60% N2O alters plasma concentrations of corticosterone (CORT), epinephrine (EPI), and norepinephrine (NE) in male Long-Evans rats. A gas-tight swivel assembly in the lid of a gas administration chamber allowed the remote collection ...
1 CitationsSource
1 CitationsSource
#1Karl J. Kaiyala (UW: University of Washington)H-Index: 20
#2Kayoko Ogimoto (UW: University of Washington)H-Index: 19
Last. Gregory J. Morton (UW: University of Washington)H-Index: 41
view all 5 authors...
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#1Gregory J. Morton (UW: University of Washington)H-Index: 41
#2Kenjiro Muta (UW: University of Washington)H-Index: 4
Last. Michael W. Schwartz (UW: University of Washington)H-Index: 106
view all 14 authors...
Dynamic adjustment of insulin secretion to compensate for changes of insulin sensitivity that result from alteration of nutritional or metabolic status is a fundamental aspect of glucose homeostasis. To investigate the role of the brain in this coupling process, we used cold exposure as an experimental paradigm, since the sympathetic nervous system (SNS) helps to coordinate the major shifts of tissue glucose utilization needed to ensure that increased thermogenic needs are met. We found that in ...
10 CitationsSource
#1Laura J. Den Hartigh (UW: University of Washington)H-Index: 11
#2Shari Wang (UW: University of Washington)H-Index: 15
Last. Alan Chait (UW: University of Washington)H-Index: 75
view all 13 authors...
Background Widely used as a weight loss supplement, trans-10,cis-12 conjugated linoleic acid (10,12 CLA) promotes fat loss in obese mice and humans, but has also been associated with insulin resistance. Objective We therefore sought to directly compare weight loss by 10,12 CLA versus caloric restriction (CR, 15–25%), an acceptable healthy method of weight loss, to determine how 10,12 CLA-mediated weight loss fails to improve glucose metabolism. Methods Obese mice with characteristics of human me...
9 CitationsSource
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