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Karl J. Kaiyala
University of Washington
64Publications
20H-index
2,012Citations
Publications 64
Newest
Published on Apr 5, 2019in Obesity3.97
Karl J. Kaiyala20
Estimated H-index: 20
(UW: University of Washington)
Published on Mar 1, 2019in Diabetes7.20
Jarrad M. Scarlett8
Estimated H-index: 8
(UW: University of Washington),
Kenjiro Muta4
Estimated H-index: 4
(UW: University of Washington)
+ 14 AuthorsThomas Hoeg-Jensen16
Estimated H-index: 16
(Novo Nordisk)
We recently reported that in rodent models of type 2 diabetes (T2D), a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces remission of hyperglycemia that is sustained for weeks. To clarify the peripheral mechanisms underlying this effect, we used the Zucker diabetic fatty fa / fa rat model of T2D, which, like human T2D, is characterized by progressive deterioration of pancreatic β-cell function after hyperglycemia onset. We report that although icv FGF1 i...
Published on Feb 1, 2019in PLOS ONE2.78
Karl J. Kaiyala20
Estimated H-index: 20
(UW: University of Washington),
Brent E. Wisse26
Estimated H-index: 26
(UW: University of Washington),
John R. B. Lighton34
Estimated H-index: 34
Background Energy expenditure (EE) calculated from respirometric indirect calorimetry is most accurate when based on oxygen consumption (VO2), carbon dioxide production (VCO2) and estimated protein metabolism (PM). EE has a substantial dependence of ~7% on the respiratory quotient (RQ, VCO2/VO2) and a lesser dependence on PM, yet many studies have instead estimated EE from VO2 only while PM has often been ignored, thus reducing accuracy. In 1949 Weir proposed a method to accurately calculate EE ...
Jennifer D. Deem5
Estimated H-index: 5
(UW: University of Washington),
Kenjiro Muta4
Estimated H-index: 4
(UW: University of Washington)
+ 4 AuthorsGregory J. Morton40
Estimated H-index: 40
(UW: University of Washington)
The ability to maintain core temperature within a narrow range despite rapid and dramatic changes in environmental temperature is essential for the survival of free-living mammals, and growing evid...
Published on May 4, 2018in Stress2.17
Salwa Al-Noori4
Estimated H-index: 4
(UW: University of Washington),
Andreas Cimpan1
Estimated H-index: 1
(UW: University of Washington)
+ 2 AuthorsDouglas S. Ramsay22
Estimated H-index: 22
(UW: University of Washington)
AbstractNitrous oxide (N2O) is a gaseous drug with abuse potential. Despite its common clinical use, little is known about whether N2O administration activates the HPA axis and/or the sympathetic adrenomedullary system. The goal of this study was to determine whether 60% N2O alters plasma concentrations of corticosterone (CORT), epinephrine (EPI), and norepinephrine (NE) in male Long-Evans rats. A gas-tight swivel assembly in the lid of a gas administration chamber allowed the remote collection ...
Published on Apr 1, 2017in Diabetes7.20
Gregory J. Morton40
Estimated H-index: 40
(UW: University of Washington),
Kenjiro Muta4
Estimated H-index: 4
(UW: University of Washington)
+ 11 AuthorsDarko Stefanovski3
Estimated H-index: 3
(UPenn: University of Pennsylvania)
Dynamic adjustment of insulin secretion to compensate for changes of insulin sensitivity that result from alteration of nutritional or metabolic status is a fundamental aspect of glucose homeostasis. To investigate the role of the brain in this coupling process, we used cold exposure as an experimental paradigm, since the sympathetic nervous system (SNS) helps to coordinate the major shifts of tissue glucose utilization needed to ensure that increased thermogenic needs are met. We found that in ...
Published on Apr 1, 2017in Molecular metabolism6.18
Karl J. Kaiyala20
Estimated H-index: 20
(UW: University of Washington),
Kayoko Ogimoto19
Estimated H-index: 19
(UW: University of Washington)
+ 2 AuthorsGregory J. Morton40
Estimated H-index: 40
(UW: University of Washington)
Published on Feb 28, 2017in PLOS ONE2.78
Laura J. Den Hartigh11
Estimated H-index: 11
(UW: University of Washington),
Shari Wang14
Estimated H-index: 14
(UW: University of Washington)
+ 10 AuthorsKevin D. O’Brien26
Estimated H-index: 26
(UW: University of Washington)
Background Widely used as a weight loss supplement, trans-10,cis-12 conjugated linoleic acid (10,12 CLA) promotes fat loss in obese mice and humans, but has also been associated with insulin resistance. Objective We therefore sought to directly compare weight loss by 10,12 CLA versus caloric restriction (CR, 15–25%), an acceptable healthy method of weight loss, to determine how 10,12 CLA-mediated weight loss fails to improve glucose metabolism. Methods Obese mice with characteristics of human me...
Published on Oct 1, 2016in Molecular metabolism6.18
Karl J. Kaiyala20
Estimated H-index: 20
(UW: University of Washington),
Kayoko Ogimoto19
Estimated H-index: 19
(UW: University of Washington)
+ 2 AuthorsGregory J. Morton40
Estimated H-index: 40
(UW: University of Washington)
Abstract Objective To investigate the role played by leptin in thermoregulation, we studied the effects of physiological leptin replacement in leptin-deficient ob/ob mice on determinants of energy balance, thermogenesis and heat retention under 3 different ambient temperatures. Methods The effects of housing at 14 °C, 22 °C or 30 °C on core temperature (telemetry), energy expenditure (respirometry), thermal conductance, body composition, energy intake, and locomotor activity (beam breaks) were m...
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