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L. Sian Gramates
Harvard University
GeneDrosophila melanogasterGeneticsFlyBase : A Database of Drosophila Genes & GenomesBiology
14Publications
9H-index
886Citations
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Publications 13
Newest
#2Julie AgapiteH-Index: 1
Last. Karen YookH-Index: 7
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7 CitationsSource
#1Jim Thurmond (IU: Indiana University Bloomington)H-Index: 5
#2Joshua L. Goodman (IU: Indiana University Bloomington)H-Index: 6
Last. Phillip W. BakerH-Index: 5
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71 CitationsSource
#1L. Sian Gramates (Harvard University)H-Index: 9
#2Steven J. Marygold (University of Cambridge)H-Index: 14
Last. Pinglei Zhou (Harvard University)H-Index: 7
view all 18 authors...
355 CitationsSource
#1Steven J. Marygold (University of Cambridge)H-Index: 14
#2Giulia Antonazzo (University of Cambridge)H-Index: 4
Last. Jim Thurmond (IU: Indiana University Bloomington)H-Index: 5
view all 11 authors...
FlyBase (flybase.org) is the primary online database of genetic, genomic, and functional information about Drosophila species, with a major focus on the model organism Drosophila melanogaster. The long and rich history of Drosophila research, combined with recent surges in genomic-scale and high-throughput technologies, mean that FlyBase now houses a huge quantity of data. Researchers need to be able to rapidly and intuitively query these data, and the QuickSearch tool has been designed to meet ...
2 CitationsSource
#1Gillian H. Millburn (University of Cambridge)H-Index: 14
#2Madeline A. Crosby (Harvard University)H-Index: 19
Last. Susan Tweedie (University of Cambridge)H-Index: 24
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The use of Drosophila melanogaster as a model for studying human disease is well established, reflected by the steady increase in both the number and proportion of fly papers describing human disease models in recent years. In this article, we highlight recent efforts to improve the availability and accessibility of the disease model information in FlyBase (http://flybase.org), the model organism database for Drosophila . FlyBase has recently introduced Human Disease Model Reports, each of which...
29 CitationsSource
#1Beverley B. Matthews (Harvard University)H-Index: 9
#2Gilberto dos Santos (Harvard University)H-Index: 5
Last. William M. Gelbart (Harvard University)H-Index: 86
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We report the current status of the FlyBase annotated gene set for Drosophila melanogaster and highlight improvements based on high-throughput data. The FlyBase annotated gene set consists entirely of manually annotated gene models, with the exception of some classes of small non-coding RNAs. All gene models have been reviewed using evidence from high-throughput datasets, primarily from the modENCODE project. These datasets include RNA-Seq coverage data, RNA-Seq junction data, transcription star...
19 CitationsSource
#1Madeline A. Crosby (Harvard University)H-Index: 19
#2L. Sian Gramates (Harvard University)H-Index: 9
Last. William M. Gelbart (Harvard University)H-Index: 86
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In the context of the FlyBase annotated gene models in Drosophila melanogaster, we describe the many exceptional cases we have curated from the literature or identified in the course of FlyBase analysis. These range from atypical but common examples such as dicistronic and polycistronic transcripts, noncanonical splices, trans-spliced transcripts, noncanonical translation starts, and stop-codon readthroughs, to single exceptional cases such as ribosomal frameshifting and HAC1-type intron process...
9 CitationsSource
#1Michael F. LinH-Index: 23
#2Joseph W. CarlsonH-Index: 32
Last. Manolis KamvysselisH-Index: 94
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The availability of sequenced genomes from 12 Drosophila species has enabled the use of comparative genomics for the systematic discovery of functional elements conserved within this genus. We have developed quantitative metrics for the evolutionary signatures specific to protein-coding regions and applied them genome-wide, resulting in 1193 candidate new protein-coding exons in the D. melanogaster genome. We have reviewed these predictions by manual curation and validated a subset by directed c...
121 CitationsSource
#1David Gorczyca (UMMS: University of Massachusetts Medical School)H-Index: 6
#2James A. Ashley (UMMS: University of Massachusetts Medical School)H-Index: 16
Last. Vivian Budnik (UMMS: University of Massachusetts Medical School)H-Index: 48
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Targeted membrane addition is a hallmark of many cellular functions. In the nervous system, modification of synaptic membrane size has a major impact on synaptic function. However, because of the complex shape of neurons and the need to target membrane addition to very small and polarized synaptic compartments, this process is poorly understood. Here, we show that Gtaxin (GTX), a Drosophila t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor), is required for ex...
39 CitationsSource
#1L. Sian Gramates (UMass: University of Massachusetts Amherst)H-Index: 9
The Darwin Centre The Natural History Museum. Cromwell Road, London SW7 5BD, UK. www.nhm.ac.uk/darwincentre/ The newest building at London9s Natural History Museum in London combines storage facilities for the specimens preserved in alcohol and a behind-the-scenes view of museum work and research.
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