Maria Concetta Fargnoli
University of L'Aquila
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Publications 179
#1Giulio GualdiH-Index: 10
#2Simone Caravello (University of Brescia)H-Index: 2
Last. Celia RequenaH-Index: 24
view all 16 authors...
INTRODUCTION Keratinocyte tumors (KT) are frequently observed. Surgery is the treatment gold standard. In some cases, a surgical approach might not be the best option. Radiotherapy (RT) and systemic treatments can frequently cause side effects or be contraindicated. Intralesional methotrexate (MTX) can be a conservative yet effective alternative. We decided to evaluate the effectiveness and safety of intralesional chemotherapy with MTX for the treatment of squamous cell carcinoma (SCC), keratoac...
#1Valeria Ciciarelli (University of L'Aquila)H-Index: 3
#2Alessio Cortellini (University of L'Aquila)H-Index: 6
Last. Maria Concetta Fargnoli (University of L'Aquila)H-Index: 28
view all 6 authors...
#1Olga Nigro (Ospedale di Circolo e Fondazione Macchi)H-Index: 1
#2Graziella Pinotti (Ospedale di Circolo e Fondazione Macchi)H-Index: 30
Last. Annamaria CatinoH-Index: 7
view all 51 authors...
Abstract Background Data on spectrum and grade of immune-related adverse events (irAEs) in long-term responders to immune checkpoint inhibitors (ICIs) are lacking. Methods We performed a retrospective multicenter study to characterized irAEs occurring after a 12-months minimum treatment period with PD-(L)1 ICIs in patients with advanced cancer. IrAEs were categorized into ‘early’ (≤12 months) and ‘late’ (>12 months). Results From September 2013 to October 2019, 436 consecutive patients were eval...
1 CitationsSource
#1Alessio Cortellini (University of L'Aquila)H-Index: 6
#2Domenico MallardoH-Index: 8
Last. Olga NigroH-Index: 2
view all 17 authors...
#1Maria Giovanna Maturo (University of L'Aquila)H-Index: 4
#2Sivaramakrishna Rachakonda (DKFZ: German Cancer Research Center)H-Index: 6
Last. Onofre SanmartínH-Index: 26
view all 15 authors...
Basal cell carcinoma (BCC) represents the most commonly diagnosed human cancer among persons of European ancestry with etiology mainly attributed to sun-exposure. In this study we investigated mutations in coding and flanking regions of PTCH1 and TP53 and noncoding alterations in the TERT and DPH3 promoters in 191 BCC tumors. In addition, we measured CpG methylation within the TERT hypermethylated oncological region (THOR) and transcription levels of the reverse transcriptase subunit. We observe...
#1Andrea Chiricozzi (CUA: The Catholic University of America)H-Index: 25
#2Maria Esposito (University of L'Aquila)H-Index: 1
Last. Maria Concetta Fargnoli (University of L'Aquila)H-Index: 28
view all 11 authors...
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is associated with higher rates of psychological disorders, but limited evidence supported the association with alexithymia, a psychoaffective dysfunction. OBJECTIVES: This study was aimed to investigate the occurrence of alexithymia in AD patients, compared to healthy subjects. METHODS: This cross-sectional study assessed AD severity by the Eczema Area and Severity Index (EASI) score, sleeplessness and itch by a num...
#1Saverio CainiH-Index: 21
#2Sara GandiniH-Index: 50
Last. David PolskyH-Index: 35
view all 27 authors...
#1Maria Teresa Landi (NIH: National Institutes of Health)H-Index: 62
#3D. Timothy Bishop (University of Leeds)H-Index: 63
Last. Jiyeon Choi (NIH: National Institutes of Health)H-Index: 7
view all 158 authors...
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10−8) loci with 68 independent single nucleotide polymorphisms. Analysis of risk estimates across geographical regions and host factors suggests the acral melanoma subtype is uniquely unrelated to pigmentation. Combining this meta-analysis with GWAS of nevus count an...
1 CitationsSource
#1Alexander J. Stratigos (UoA: National and Kapodistrian University of Athens)H-Index: 36
#2Claus GarbeH-Index: 89
Last. Cecille Frenard (University of Nantes)H-Index: 1
view all 28 authors...
Abstract Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the white populations, accounting for 20% of all cutaneous malignancies. Factors implicated in cSCC etiopathogenesis include ultraviolet radiation exposure and chronic photoaging, age, male sex, immunosuppression, smoking and genetic factors. A collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Orga...
1 CitationsSource