Neil E. Caporaso
National Institutes of Health
Publications 589
#1Shuchun Lin (CAS: Chinese Academy of Sciences)H-Index: 1
#2Yun Liu (Fudan University)H-Index: 17
Last.Ying Gao (CAS: Chinese Academy of Sciences)H-Index: 96
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Men are at higher risk of developing chronic lymphocytic leukemia (CLL) than women. DNA methylation has been shown to play important roles in a number of cancers. There are differences in the DNA methylation pattern between men and women. In this study, we investigated whether this contributes to the sex-related difference of B cell CLL risk. Using the HumanMethylation450 BeadChip, we profiled the genome-wide DNA methylation pattern of CD19+ B cells from 48 CLL patients (29 female patients and 1...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Hilary K. Finucane (Broad Institute)H-Index: 29
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Hilary K. Finucane (Broad Institute)H-Index: 29
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
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Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
#1Juncheng Dai (Nanjing Medical University)H-Index: 32
#2Mingtao Huang (Nanjing Medical University)H-Index: 2
Last.Hongbing Shen (Nanjing Medical University)H-Index: 54
view all 39 authors...
#1Xia JiangH-Index: 6
#2Hilary K. FinucaneH-Index: 29
Last.Sara LindstroemH-Index: 46
view all 333 authors...
textabstractAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
#1Anouar Fanidi (University of Cambridge)H-Index: 2
#2Robert Carreras-Torres (IARC: International Agency for Research on Cancer)H-Index: 7
Last.Paul Brennan (IARC: International Agency for Research on Cancer)H-Index: 94
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Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre-diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,2...
#1Yan Zhang (Johns Hopkins University)H-Index: 4
#2Amber N. Wilcox (UNC: University of North Carolina at Chapel Hill)
Last.Montserrat Garcia-ClosasH-Index: 82
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We analyzed summary-level data from genome-wide association studies (GWAS) of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) contributing to risk, as well as the distribution of their associated effect sizes. All cancers evaluated showed polygenicity, involving at a minimum thousands of independent susceptibility variants. For some malignancies, particularly chronic lymphoid leukemia (CLL) and testicular cancer, susceptibili...
#1Dario Consonni (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 50
#2Cristina Calvi (fondazione bruno kessler)
Last.Carolina Mensi (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 16
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Objectives Asbestos is the main risk factor for peritoneal mesothelioma (PeM). However, due to its rarity, PeM has rarely been investigated in community-based studies. We examined the association between asbestos exposure and PeM risk in a general population in Lombardy, Italy. Methods From the regional mesothelioma registry, we selected PeM cases diagnosed in 2000–2015. Population controls (matched by area, gender and age) came from two case–control studies in Lombardy on lung cancer (2002–2004...