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Jeremy C. Mottram
University of York
Molecular biologyTrypanosoma bruceiLeishmania mexicanaBiochemistryBiology
264Publications
61H-index
18.9kCitations
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Publications 266
Newest
#1Andreas Damianou (Glas.: University of Glasgow)
#2Rebecca Jayne Burge (Ebor: University of York)
Last. Jeremy C. Mottram (Ebor: University of York)H-Index: 61
view all 10 authors...
The parasitic protozoan Leishmania requires proteasomal, autophagic and lysosomal proteolytic pathways to enact the extensive cellular remodelling that occurs during its life cycle. The proteasome is essential for parasite proliferation, yet little is known about the requirement for ubiquitination/deubiquitination processes in growth and differentiation. Activity-based protein profiling of L. mexicana C12, C19 and C65 deubiquitinating cysteine peptidases (DUBs) revealed DUB activity remains rela...
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#1John W. Davey (Ebor: University of York)H-Index: 22
#2Seth J Davis (Ebor: University of York)H-Index: 45
Last. Peter D. Ashton (Ebor: University of York)H-Index: 2
view all 4 authors...
Small eukaryotic genome assemblies based on long reads are often close to complete, but still require validation and editing. Tapestry produces an interactive report which can be used to validate, sort and filter the contigs in a raw genome assembly, taking into account GC content, telomeres, read depths, contig alignments and read alignments. The report can be shared with collaborators and included as supplemental material in publications.
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#1Jack Sunter (Oxford Brookes University)H-Index: 17
#2Clare Halliday (Oxford Brookes University)H-Index: 1
Last. Jeremy C. Mottram (Ebor: University of York)H-Index: 61
view all 9 authors...
The shape and form of the flagellated eukaryotic parasite Leishmania is sculpted to its ecological niches and needs to be transmitted to each generation with great fidelity. The shape of the Leishmania cell is defined by the sub-pellicular microtubule array and the positioning of the nucleus, kinetoplast and the flagellum within this array. The flagellum emerges from the anterior end of the cell body through an invagination of the cell body membrane called the flagellar pocket. Within the flagel...
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#1Elena A. Minina (Heidelberg University)H-Index: 16
#2Jens Staal (UGent: Ghent University)H-Index: 19
Last. Juan José CazzuloH-Index: 39
view all 48 authors...
2 CitationsSource
#1Andreas Damianou (Ebor: University of York)
#2Rebecca Jayne Burge (Ebor: University of York)
Last. Jeremy C. Mottram (Ebor: University of York)H-Index: 61
view all 10 authors...
The parasitic protozoan Leishmania requires proteasomal, autophagic and lysosomal proteolytic pathways to enact the extensive cellular remodelling that occurs during its life cycle. The proteasome is essential for parasite proliferation, yet little is known about the requirement for ubiquitination/deubiquitination processes in growth and differentiation. Activity-based protein profiling of L. mexicana C12, C19 and C65 deubiquitinating cysteine peptidases (DUBs) revealed DUB activity remains rela...
Source
#1Emily A. Dickie (Glas.: University of Glasgow)
#2Federica Giordani (Glas.: University of Glasgow)H-Index: 7
Last. Michael P. Barrett (Glas.: University of Glasgow)H-Index: 59
view all 8 authors...
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success against HAT and the competing priorities associated with other medical crises ravaging the continent. A series of dedicated interventions and the introduction of innovative routes to develop drugs, involving Product Development Partnerships, has led...
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#1Srinivasa P. S. Rao (Novartis Institute for Tropical Diseases)H-Index: 22
#2Suresh B. Lakshminarayana (Novartis Institute for Tropical Diseases)H-Index: 20
Last. Valentina Molteni (Genomics Institute of the Novartis Research Foundation)H-Index: 20
view all 14 authors...
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the triazolopyrimidine (TP) class as selective kinetoplastid proteasome inhibitors with in vivo efficacy in mouse models of leishmaniasis, Chagas Disease and African trypanosomiasis (HAT). For the treatment of HAT, development compounds need to have excellen...
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#1Jennifer Ann Black (Glas.: University of Glasgow)H-Index: 2
#2Kathryn Crouch (Glas.: University of Glasgow)H-Index: 9
Last. Richard McCulloch (Glas.: University of Glasgow)H-Index: 28
view all 8 authors...
Summary Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time. DNA repair activities have been implicated in the catalysis of VSG switching by recombination, not transcriptional control. How VSG switching is signaled to guide the appropriate reaction or to integrate switching into parasite growth is unknown. H...
3 CitationsSource
#1Ryan Ritchie (Glas.: University of Glasgow)H-Index: 4
#2Michael P. Barrett (Glas.: University of Glasgow)H-Index: 59
Last. Elmarie Myburgh (Hull York Medical School)H-Index: 13
view all 4 authors...
: Traditional animal models for human African trypanosomiasis rely on detecting Trypanosoma brucei brucei parasitemia in the blood. Testing the efficacy of new compounds in these models is cumbersome because it may take several months after treatment before surviving parasites become detectable in the blood. To expedite compound screening, we have used a Trypanosoma brucei brucei GVR35 strain expressing red-shifted firefly luciferase to monitor parasite distribution in infected mice through noni...
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#1Sarah N. Forrester (Ebor: University of York)H-Index: 9
#2Karin Siefert (Lond: University of London)
Last. Paul M. Kaye (Ebor: University of York)H-Index: 51
view all 12 authors...
Background: Liposomal amphotericin B (AmBisome®) as a treatment modality for visceral leishmaniasis (VL) has had significant impact on patient care in some but not all regions where VL is endemic. As the mode of action of AmBisome® in vivo is poorly understood, we compared the tissue-specific transcriptome in drug-treated vs untreated mice with experimental VL. Methods: BALB/c mice infected with L. donovani w ere treated with 8mg/kg AmBisome®, resulting in parasite elimination from liver and spl...
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