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Stavros P. Loukogeorgakis
University College London
CardiologyStem cellTransplantationDiabetes mellitusMedicine
61Publications
17H-index
3,087Citations
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Publications 75
Newest
#1Panicos Shangaris (UCL: University College London)H-Index: 8
#2Stavros P. Loukogeorgakis (ICH: UCL Institute of Child Health)H-Index: 17
Last. Anna L. David (UCL: University College London)H-Index: 31
view all 23 authors...
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#1Stavros P. Loukogeorgakis (UCL: University College London)H-Index: 17
#1Stavros P. Loukogeorgakis (Children's Hospital of Philadelphia)H-Index: 1
Last. Alan W. Flake (Children's Hospital of Philadelphia)H-Index: 71
view all 17 authors...
: Host cell competition is a major barrier to engraftment after in utero hematopoietic cell transplantation (IUHCT). Here we describe a cell-engineering strategy using glycogen synthase kinase-3 (GSK3) inhibitor-loaded nanoparticles conjugated to the surface of donor hematopoietic cells to enhance their proliferation kinetics and ability to compete against their fetal host equivalents. With this approach, we achieved remarkable levels of stable, long-term hematopoietic engraftment for up to 24 w...
2 CitationsSource
#1Kristin V. Veighey (University Hospital Southampton NHS Foundation Trust)H-Index: 1
#2Jennifer M. Nicholas (Lond: University of London)H-Index: 22
Last. Raymond J. MacAllister (Dorset County Hospital NHS Foundation Trust)H-Index: 46
view all 11 authors...
Abstract Background The REnal Protection Against Ischaemia–Reperfusion in transplantation (REPAIR) RCT examined whether remote ischaemic preconditioning (RIPC) improved renal function after living-donor kidney transplantation. The primary endpoint, glomerular filtration rate (GFR), quantified by iohexol at 12 months, suggested that RIPC may confer longer-term benefit. Here, we present yearly follow-up data of estimated GFR for up to 5 yr after transplantation. Methods In this double-blind, facto...
2 CitationsSource
#1Stavros P. Loukogeorgakis (UCL: University College London)H-Index: 17
#2Panicos Shangaris (UCL: University College London)H-Index: 8
Last. P De Coppi (UCL: University College London)H-Index: 16
view all 20 authors...
In utero transplantation (IUT) of hematopoietic stem cells (HSC) has been proposed as a strategy for the prenatal treatment of congenital hematological diseases. However, levels of long-term hematopoietic engraftment achieved in experimental IUT to date are sub-therapeutic, likely due to host fetal HSC out-competing their bone-marrow (BM) derived donor equivalents for space in the hematopoietic compartment. In the present study we demonstrate that amniotic fluid stem cells (AFSC; c-Kit+/Lin-) ha...
2 CitationsSource
#1Panicos Shangaris (UCL: University College London)H-Index: 8
#2Stavros P. Loukogeorgakis (ICH: UCL Institute of Child Health)H-Index: 17
Last. Anna L. David (UCL: University College London)H-Index: 31
view all 23 authors...
In utero gene therapy (IUGT) to the fetal hematopoietic compartment could be used to treat congenital blood disorders such as β-thalassemia. A humanised mouse model of β-thalassemia was used, in which heterozygous animals are anaemic with splenomegaly and extramedullary hematopoiesis. Intrahepatic in utero injections of a β globin-expressing lentiviral vector (GLOBE), were performed in fetuses at E13.5 of gestation. We analysed animals at 12 and 32 weeks of age, for vector copy number in bone ma...
Source
#1Luca Urbani (UCL: University College London)H-Index: 17
#2C Camilli (UCL: University College London)H-Index: 3
Last. P De Coppi (UCL: University College London)H-Index: 16
view all 31 authors...
A tissue engineered oesophagus could overcome limitations associated with oesophageal substitution. Combining decellularized scaffolds with patient-derived cells shows promise for regeneration of tissue defects. In this proof-of-principle study, a two-stage approach for generation of a bio-artificial oesophageal graft addresses some major challenges in organ engineering, namely: (i) development of multi-strata tubular structures, (ii) appropriate re-population/maturation of constructs before tra...
17 CitationsSource
#1Anna Urciuolo (UCL: University College London)H-Index: 3
#1A Urciuolo (UCL: University College London)H-Index: 3
Last. P De Coppi (UCL: University College London)H-Index: 16
view all 17 authors...
Pathological conditions affecting skeletal muscle function may lead to irreversible volumetric muscle loss (VML). Therapeutic approaches involving acellular matrices represent an emerging and promising strategy to promote regeneration of skeletal muscle following injury. Here we investigated the ability of three different decellularised skeletal muscle scaffolds to support muscle regeneration in a xenogeneic immune-competent model of VML, in which the EDL muscle was surgically resected. All impl...
14 CitationsSource
#2P De CoppiH-Index: 16
Ascites (Greek: ascos; “baglike”) is a gastroenterological term that describes the accumulation of fluid, which may consist of transudates (low protein count) or exudates (high protein count). The incidence of ascites in paediatric patients is unknown, but the condition is rare. Ascites may be present in the fetus, and there are significant differences in its aetiology between neonates and older children.
Source
#1Nicholas J. Ahn (Children's Hospital of Philadelphia)H-Index: 2
#2John D. Stratigis (Children's Hospital of Philadelphia)H-Index: 4
Last. Alan W. Flake (Children's Hospital of Philadelphia)H-Index: 71
view all 10 authors...
Introduction In utero hematopoietic cell transplantation (IUHCT) of allogenic bone marrow mononuclear cells (BM MNC) results in mixed hematopoietic chimerism in the murine model. In contrast, highly enriched HSCs (LSKs: Lin- c-Kit+ Sca-1+ cells) do not engraft after allogeneic IUHCT. Tracking studies in the first 72 hours after IUHCT demonstrate relatively large numbers of donor cells in the fetal thymus after IUHCT of BM MNCs, but not after IUHCT of LSK cells. This suggests that a sub-populatio...
#1Stavros P. Loukogeorgakis (UCL: University College London)H-Index: 17
#2Paolo De Coppi (UCL: University College London)H-Index: 49
Last. P De CoppiH-Index: 16
view all 2 authors...
The amniotic fluid has been identified as an untapped source of cells with broad potential, which possess immunomodulatory properties and do not have the ethical and legal limitations of embryonic stem cells. CD117(c-Kit)+ cells selected from amniotic fluid have been shown to differentiate into cell lineages representing all three embryonic germ layers without generating tumors, making them ideal candidates for regenerative medicine applications. Moreover, their ability to engraft in injured org...
32 CitationsSource
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