Stavros P. Loukogeorgakis
University College London
Publications 70
#1Panicos Shangaris (UCL: University College London)H-Index: 7
#2Stavros P. Loukogeorgakis (ICH: UCL Institute of Child Health)H-Index: 20
Last.Anna L. David (UCL: University College London)H-Index: 30
view all 23 authors...
In utero gene therapy (IUGT) to the fetal hematopoietic compartment could be used to treat congenital blood disorders such as β-thalassemia. A humanised mouse model of β-thalassemia was used, in which heterozygous animals are anaemic with splenomegaly and extramedullary hematopoiesis. Intrahepatic in utero injections of a β globin-expressing lentiviral vector (GLOBE), were performed in fetuses at E13.5 of gestation. We analysed animals at 12 and 32 weeks of age, for vector copy number in bone ma...
#1Kristin V. Veighey (University Hospital Southampton NHS Foundation Trust)H-Index: 1
#2Jennifer M. Nicholas (Lond: University of London)H-Index: 20
Last.Raymond J. MacAllister (Dorset County Hospital NHS Foundation Trust)H-Index: 45
view all 11 authors...
Abstract Background The REnal Protection Against Ischaemia–Reperfusion in transplantation (REPAIR) RCT examined whether remote ischaemic preconditioning (RIPC) improved renal function after living-donor kidney transplantation. The primary endpoint, glomerular filtration rate (GFR), quantified by iohexol at 12 months, suggested that RIPC may confer longer-term benefit. Here, we present yearly follow-up data of estimated GFR for up to 5 yr after transplantation. Methods In this double-blind, facto...
1 CitationsSource
#1Stavros P. Loukogeorgakis (UCL: University College London)H-Index: 20
#2Panicos Shangaris (UCL: University College London)H-Index: 7
Last.P De Coppi (UCL: University College London)H-Index: 56
view all 20 authors...
1 CitationsSource
#1A Urciuolo (UCL: University College London)H-Index: 3
#2Luca Urbani (UCL: University College London)H-Index: 15
Last.P De Coppi (UCL: University College London)H-Index: 56
view all 17 authors...
Pathological conditions affecting skeletal muscle function may lead to irreversible volumetric muscle loss (VML). Therapeutic approaches involving acellular matrices represent an emerging and promising strategy to promote regeneration of skeletal muscle following injury. Here we investigated the ability of three different decellularised skeletal muscle scaffolds to support muscle regeneration in a xenogeneic immune-competent model of VML, in which the EDL muscle was surgically resected. All impl...
8 CitationsSource
#1Luca Urbani (UCL: University College London)H-Index: 15
#2C Camilli (UCL: University College London)H-Index: 2
Last.P De Coppi (UCL: University College London)H-Index: 56
view all 31 authors...
A tissue engineered oesophagus could overcome limitations associated with oesophageal substitution. Combining decellularized scaffolds with patient-derived cells shows promise for regeneration of tissue defects. In this proof-of-principle study, a two-stage approach for generation of a bio-artificial oesophageal graft addresses some major challenges in organ engineering, namely: (i) development of multi-strata tubular structures, (ii) appropriate re-population/maturation of constructs before tra...
9 CitationsSource
#2P De CoppiH-Index: 56
Ascites (Greek: ascos; “baglike”) is a gastroenterological term that describes the accumulation of fluid, which may consist of transudates (low protein count) or exudates (high protein count). The incidence of ascites in paediatric patients is unknown, but the condition is rare. Ascites may be present in the fetus, and there are significant differences in its aetiology between neonates and older children.
#1Nicholas J. Ahn (Children's Hospital of Philadelphia)H-Index: 1
#2John D. Stratigis (Children's Hospital of Philadelphia)H-Index: 3
Last.Alan W. Flake (Children's Hospital of Philadelphia)H-Index: 70
view all 10 authors...
Introduction In utero hematopoietic cell transplantation (IUHCT) of allogenic bone marrow mononuclear cells (BM MNC) results in mixed hematopoietic chimerism in the murine model. In contrast, highly enriched HSCs (LSKs: Lin- c-Kit+ Sca-1+ cells) do not engraft after allogeneic IUHCT. Tracking studies in the first 72 hours after IUHCT demonstrate relatively large numbers of donor cells in the fetal thymus after IUHCT of BM MNCs, but not after IUHCT of LSK cells. This suggests that a sub-populatio...
The amniotic fluid has been identified as an untapped source of cells with broad potential, which possess immunomodulatory properties and do not have the ethical and legal limitations of embryonic stem cells. CD117(c-Kit)+ cells selected from amniotic fluid have been shown to differentiate into cell lineages representing all three embryonic germ layers without generating tumors, making them ideal candidates for regenerative medicine applications. Moreover, their ability to engraft in injured org...
22 CitationsSource
#1P Maghsoudlou (ICH: UCL Institute of Child Health)H-Index: 14
#2Fanourios Georgiades (ICH: UCL Institute of Child Health)H-Index: 2
Last.P De Coppi (ICH: UCL Institute of Child Health)H-Index: 56
view all 18 authors...
Hepatic tissue engineering using decellularized scaffolds is a potential therapeutic alternative to conventional transplantation. However, scaffolds are usually obtained using decellularization protocols that destroy the extracellular matrix (ECM) and hamper clinical translation. We aim to develop a decellularization technique that reliably maintains hepatic microarchitecture and ECM components. Isolated rat livers were decellularized by detergent-enzymatic technique with (EDTA-DET) or without E...
22 CitationsSource