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Catherine Maiteki-Sebuguzi
Makerere University
Public healthImmunologyPsychological interventionMalariaMedicine
27Publications
11H-index
573Citations
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Publications 27
Newest
#1Sarah G. Staedke (Lond: University of London)H-Index: 40
#2Samuel GonahasaH-Index: 5
Last. Simon P. KigoziH-Index: 6
view all 13 authors...
Summary Background Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda's national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors. Methods 104 health sub-districts, from 48 districts in Uganda, were randomly assigned t...
1 CitationsSource
#1Rebecca Thomson (Lond: University of London)H-Index: 6
#2Khalid B. Beshir (Lond: University of London)H-Index: 13
Last. Heidi Hopkins (Lond: University of London)H-Index: 14
view all 10 authors...
Background Malaria rapid diagnostic tests (mRDT) that target histidine-rich protein 2 (HRP2) are important tools for Plasmodium falciparum diagnosis. Parasites with pfhrp2/3 gene deletions threaten the use of these mRDTs, and have been reported in Africa, Asia, and South America. We studied blood samples from three African countries to determine if these gene deletions were present. Methods We analysed 911 dried blood spots from Ghana (165), Tanzania (176) and Uganda (570). P.falciparum infectio...
1 CitationsSource
#1Andrea M. Rehman (Lond: University of London)H-Index: 14
Last. Sarah G. Staedke (Lond: University of London)H-Index: 40
view all 10 authors...
Intermittent preventive treatment (IPT) of malaria is recommended as policy for certain high-risk populations, but not currently for schoolchildren. A cluster-randomized trial was conducted to evaluate the effect of IPT with dihydroartemisinin–piperaquine (DP) on primary schoolchildren in Jinja, Uganda. Results of the impact of IPT of schoolchildren on community-level transmission have been reported previously. Here, secondary outcomes from a school-based survey are presented. Eighty-four cluste...
Source
#1Sheila Rugnao (UCSF: University of California, San Francisco)H-Index: 2
#2Samuel GonahasaH-Index: 5
Last. Sarah G. Staedke (Lond: University of London)H-Index: 40
view all 13 authors...
Background Recent reductions in malaria burden have been attributed largely to long-lasting insecticidal nets (LLINs). In March–June 2017, approximately 3 years after a national LLIN distribution campaign, a cross-sectional community survey was conducted to investigate factors associated with malaria parasitaemia and anaemia, in advance of Uganda’s 2017–2018 LLIN campaign.
1 CitationsSource
#1Sarah G. Staedke (Lond: University of London)H-Index: 40
#2Moses R. Kamya (MUK: Makerere University)H-Index: 52
Last. Martin J. Donnelly (LSTM: Liverpool School of Tropical Medicine)H-Index: 42
view all 10 authors...
Long-lasting insecticidal nets (LLINs) are a key malaria control intervention, but their effectiveness is threatened by resistance to pyrethroid insecticides. Some new LLINs combine pyrethroids with piperonyl butoxide (PBO), a synergist that can overcome P450-based metabolic resistance to pyrethroids in mosquitoes. In 2017–2018, the Ugandan Ministry of Health distributed LLINs with and without PBO through a national mass-distribution campaign, providing a unique opportunity to rigorously evaluat...
1 CitationsSource
#1Amy Lynd (LSTM: Liverpool School of Tropical Medicine)H-Index: 12
#2Samuel GonahasaH-Index: 5
Last. Martin J. Donnelly (LSTM: Liverpool School of Tropical Medicine)H-Index: 42
view all 13 authors...
Background Long-lasting insecticidal nets (LLINs) are the principal tool for malaria control in Africa and are presently treated with a single class of insecticide; however, increasing levels of insecticide resistance threaten their success. In response to this threat nets have been developed that incorporate the synergist, piperonyl butoxide (PBO), which inhibits the activity of cytochrome P450s which is one main mechanisms of insecticide resistance, allowing resistance to pyrethroids to be rev...
1 CitationsSource
#1Samuel GonahasaH-Index: 5
Last. Sarah G. Staedke (Lond: University of London)H-Index: 40
view all 13 authors...
Long-lasting insecticidal nets (LLINs) are a key malaria control intervention. To investigate factors associated with ownership and use of LLINs in Uganda, a cross-sectional community survey was conducted in March–June 2017, approximately 3 years after a national Universal Coverage Campaign (UCC). Households from 104 clusters (health sub-districts) in 48 districts were randomly selected using two-staged cluster sampling; 50 households were enrolled per cluster. Outcomes were household ownership ...
5 CitationsSource
#1Sarah G. Staedke (Lond: University of London)H-Index: 40
Last. Chris Drakeley (Lond: University of London)H-Index: 75
view all 11 authors...
Summary Background Intermittent preventive treatment (IPT) is a well established malaria control intervention. Evidence that delivering IPT to schoolchildren could provide community-level benefits is limited. We did a cluster-randomised controlled trial to assess the effect of IPT of primary schoolchildren with dihydroartemisinin-piperaquine (DP) on indicators of malaria transmission in the community, in Jinja, Uganda. Methods We included 84 clusters, each comprising one primary school and the 1...
6 CitationsSource
#1Clare I R Chandler (Lond: University of London)H-Index: 24
#2Emily L. Webb (Lond: University of London)H-Index: 37
Last. Sarah G. Staedke (Lond: University of London)H-Index: 40
view all 10 authors...
Rapid diagnostic tests for malaria (mRDTs) have been scaled-up widely across Africa. The PRIME study evaluated an intervention aiming to improve fever case management using mRDTs at public health centers in Uganda. A cluster-randomized trial was conducted from 2010-13 in Tororo, a high malaria transmission setting. Twenty public health centers were randomized in a 1:1 ratio to intervention or control. The intervention included training in health center management, fever case management with mRDT...
3 CitationsSource
#1Grant DorseyH-Index: 58
#2Sarah G. StaedkeH-Index: 40
Last. Philip RosenthalH-Index: 90
view all 7 authors...
sidered, the risks of failure were 14.1% (95% CI, 10.3%-19.2%), 4.6% (95% CI, 2.5%8.3%), and 1.0% (95% CI, 0.3%-4.0%) for the same order of study drugs, respectively (P.008 for all pairwise comparisons, except amodiaquine plus artesunate vs artemether-lumefantrine, P=.05). There were no deaths or cases of severe malaria. Significant reductions in anemia (9.3% [95% CI, 7.0%-12.0%] at enrollment vs 0.6% [95% CI, 0.1%-2.2%] during the last 2 months of follow-up; P.001) and asymptomatic parasitemia ...
11 Citations
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