William D. Steers
Department of Urology, University of Virginia
UrologyEndocrinologySurgeryUrinary incontinenceMedicine
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Publications 289
#1Parviz K. Kavoussi (Department of Urology, University of Virginia)H-Index: 7
#2Ryan P. Smith (Department of Urology, University of Virginia)H-Index: 11
Last. Lisa A. Palmer (UVA: University of Virginia)H-Index: 18
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Neuronal and endothelial nitric oxide synthases (nNOS and eNOS respectively) play major roles in generating the nitric oxide bioactivity necessary for erectile function. S-nitrosylation has been shown to regulate NOS activity. The presence of S-nitrosylated NOS in the penis and the impact of NOS S-nitrosylation/denitrosylation on erectile function were examined. S-nitrosylated forms of NOS were identified by biotin-switch assay followed by western blot analysis. Erectile function in S-nitrosoglu...
2 CitationsSource
#1Li-Ya Qiao (VCU: Virginia Commonwealth University)H-Index: 13
#2Chunmei Xia (Fudan University)H-Index: 13
Last. William D. Steers (Department of Urology, University of Virginia)H-Index: 36
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Abstract Aims The present study aims to investigate the role of Akt in the regulation of urinary bladder organ hypertrophy caused by partial bladder outlet obstruction (pBOO). Main methods Male rats were surgically induced for pBOO. Real-time PCR and western blot were used to examine the levels of mRNA and protein. A phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was used to inhibit the activity of endogenous Akt. Key findings The urinary bladder developed hypertrophy at 2 weeks of pBOO. Th...
1 CitationsSource
#1William D. Steers (Department of Urology, University of Virginia)H-Index: 36
#2Tyler C. Wind (University of Virginia Health System)H-Index: 6
Last. Richard F. Edlich (University of Virginia Health System)H-Index: 39
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: The purpose of this collective review is to examine the use of functional electrical stimulation for incontinence. The Finetech-Brindley bladder system enhances voiding through stimulation via electrodes implanted around the ventral sacral roots. Detrusor hyperreflexia is eliminated through complete dorsal rhizotomy, which results in loss of reflex defecation and reflex erection/reflex lubrication. Consequently, a new system is being devised in which functional electrical stimulation for incon...
#1Jordan DimitrakovH-Index: 10
#2Kurt KroenkeH-Index: 95
Last. Jeffrey L. JacksonH-Index: 52
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#1Parviz K. Kavoussi (Department of Urology, University of Virginia)H-Index: 7
#2K. Heberlein (University of Virginia Health System)H-Index: 1
Last. Jeffrey J. Lysiak (Department of Urology, University of Virginia)H-Index: 13
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Summary Myoendothelial junctions are specialised projections of cell : cell contact through the internal elastic lamina between endothelial cells and vascular smooth muscle cells. These junctions allow for endothelial cells and vascular smooth muscle cells to make direct membrane apposition and are involved in cell : cell communication. In this study, we evaluated for the presence of myoendothelial junctions in murine corporal tissue and used plasminogen activator inhibitor (PAI)-1-deficient mic...
1 CitationsSource
2 CitationsSource
#1Susan A. HallH-Index: 10
#2May YangH-Index: 1
Last. John B. McKinlayH-Index: 77
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#1Weiqun Yu (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 12
Last. Mark L. Zeidel (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 53
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Lower urinary tract (LUT) symptoms become prevalent with aging and affect millions; however, therapy is often ineffective because the etiology is unknown. Existing assays of LUT function in animal models are often invasive; however, a noninvasive assay is required to study symptom progression and determine genetic correlates. Here, we present a spontaneous voiding assay that is simple, reproducible, quantitative, and noninvasive. Young female mice from eight inbred mouse strains (129S1/SvImJ, A/...
42 CitationsSource