Michael J. Mihatsch
RWTH Aachen University
Publications 458
#1Volker Nickeleit (UNC: University of North Carolina at Chapel Hill)H-Index: 32
#2Harsharan K. Singh (UNC: University of North Carolina at Chapel Hill)H-Index: 16
Last.Vicki G. Davis (UNC: University of North Carolina at Chapel Hill)H-Index: 12
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Polyomavirus nephropathy (PVN) is a common viral infection of renal allografts, with biopsy-proven incidence of approximately 5%. A generally accepted morphologic classification of definitive PVN that groups histologic changes, reflects clinical presentation, and facilitates comparative outcome analyses is lacking. Here, we report a morphologic classification scheme for definitive PVN from the Banff Working Group on Polyomavirus Nephropathy, comprising nine transplant centers in the United State...
#1Beatrice Drexler (Swiss Red Cross)H-Index: 3
#2Andreas Holbro (Swiss Red Cross)H-Index: 8
Last.Thomas MenterH-Index: 10
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BACKGROUND The ABO blood group is a major determinant in living donor kidney transplantation since AB antigens are expressed on renal tissue. Little attention has been directed to the ABH-secretor status of the donor kidney. As renal tissue is capable of secreting soluble ABH antigens in secretors, we examined the influence of the ABH-secretor status of kidney donors on outcome in ABO-mismatched living donor kidney transplantation. STUDY DESIGN AND METHODS We retrospectively analyzed all patient...
#1Stefan ZschiedrichH-Index: 10
#2Tobias B. HuberH-Index: 45
Last.Thorsten WiechH-Index: 22
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Systemic karyomegaly associated with interstitial nephritis was first described in 1978 by Mihatsch. Seven cases have been reported to date. We give an account of an autopsy case of systemic karyomegaly in a 30-year-old Italian man. Bizarre enlargement of nuclei was found in renal tubular epithelial cells, Schwann cells and in smooth muscle cells of vessels and bowel and, less obviously, in endothelial and adventitial cells of vessels, in alveolar epithelial cells and in astrocytes of the brain....
#1Thomas MenterH-Index: 10
#2Michael MayrH-Index: 18
Last.Helmut HopferH-Index: 9
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Control of polyomavirus BK (BKV) is achieved by reducing immunosuppression allowing an effective BKV-specific T-cell response. The morphology of resolving BKV-associated nephropathy (PyVAN) has not been systematically investigated. Ninety-nine surveillance biopsies of 35 patients with BKV viremia treated exclusively by immunosuppression reduction were scored according to Banff criteria and grouped relative to BKV viremia as pre-, increasing, decreasing and post-BKV viremia. Thirty-four of 35 pat...
#1Felix BurkhalterH-Index: 6
#2Tobias OettlH-Index: 4
Last.Juerg SteigerH-Index: 19
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Abstract Immunosuppressive maintenance therapy after kidney transplantation leads to various undesired side effects such as calcineurin inhibitor (CNI)–associated nephrotoxicity or elevated cardiovascular risk due to posttransplantation diabetes and hypertension. These effects show negative impacts on long–term allograft function as well as patient morbidity and mortality. Therefore, we used an immunosuppressive regimen with early corticosteroid withdrawal (ESW), maintenance therapy containing t...
#1Weibin ZhouH-Index: 32
#2Edgar A. OttoH-Index: 55
Last.Heon Yung Gee (UM: University of Michigan)H-Index: 15
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Friedhelm Hildebrandt, Agata Smogorzewska and colleagues show that mutations in the DNA repair gene FAN1 cause karyomegalic interstitial nephritis. These findings implicate deficient DNA damage response signaling in the pathophysiology of renal fibrosis.
#1Yasuhiro OtsukaH-Index: 6
#2Asami TakedaH-Index: 15
Last.Kunio MorozumiH-Index: 23
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Fibronectin glomerulopathy (FNG) is a rare, autosomal dominant renal disease with massive mesangial, and subendothelial fibronectin deposits. It presents proteinuria, often in the nephrotic range in the third to fourth decade, and slow progression to end-stage renal disease. The risk of recurrent disease in renal allograft is uncertain. A Japanese female with end-stage renal disease because of unknown origin received a renal transplant and was referred with proteinuria and mild deterioration of ...