Saman Hosseinkhani
Tarbiat Modares University
LuciferaseMolecular biologyChemistryBiochemistryBiology
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Publications 300
#1Yasaman Sadat Borghei (UT: University of Tehran)H-Index: 3
#2Morteza Hosseini (UT: University of Tehran)H-Index: 31
Last. Saman Hosseinkhani (TMU: Tarbiat Modares University)H-Index: 28
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Abstract Tumor biomarkers are elements that are created by the tumor itself or other host cells in response to cancerous conditions. The detection of HER2, as one of these biomarkers, is important in order to prescribe Herceptin (trastuzumab). So, precise measurement of the HER2 status is vital to ensure that all patients with breast cancer who can use Herceptin are correctly identified. In this method, we used the optical properties of gold nanoclusters (AuNCs) in colorimetric and fluorescence ...
#1Mohsen Alipour (TMU: Tarbiat Modares University)H-Index: 7
#2Marzieh Baneshi (Cape Breton University)
Last. Hassan BardaniaH-Index: 8
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Arginine-glycine-aspartic acid (RGD) peptide family is known as the most prominent ligand for extracellular domain of integrin receptors. Specific expression of these receptors in various tissue of human body and tight association of their expression profile with various pathophysiological conditions made these receptors a suitable targeting candidate for several disease diagnosis and treatment as well as regeneration of various organs. For these reasons, various forms of RGD-based integrins lig...
The apoptotic protease-activating factor 1 (Apaf-1) split luciferase biosensor has been used as a biological tool for the detection of early stage of apoptosis. The effect of doxorubicin in a cell-based assay and the addition of cytochrome c and ATP in a cell-free system have been used to test the functionality of the reporter for the detection of apoptosome formation. Here, our data established a drug- and cytochrome c/ATP-independent way of apoptosis induction relying on the expression of the ...
#1Mojtaba Mortazavi (Graduate University of Advanced Technology)H-Index: 6
#2Masoud Torkzadeh-Mahani (Graduate University of Advanced Technology)H-Index: 17
Last. Emamzadeh Rahman (UI: University of Isfahan)H-Index: 1
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Introduction: Cancer treatment using functionalized vehicles in order to block involved genes has attracted a remarkable interest. In this study, we investigated the cellular uptake and cytotoxic effects of three sizes of anti Bcl-2 DNAi-conjugated gold nanoparticles by MCF-7 cells. Methods: Three different sizes of gold nanoparticles were synthesized by citrate reduction method and after characterization, the nanoparticles were functionalized by Bcl-2 targeted DNAi. Cell internalization of the ...
#1Sajad Najafi (FUM: Ferdowsi University of Mashhad)
#2Gholam Reza Mohammadi (FUM: Ferdowsi University of Mashhad)H-Index: 9
Last. Jalil Mehrzad (UT: University of Tehran)H-Index: 21
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Exposure to environmental toxicants that affect the immune system and overall health of many mammals is mostly unavoidable. One of the more common substances is the mycotoxins, especially carcinogenic aflatoxin (AF)B1 which also causes immune suppression/dysregulation in exposed hosts. The present study analyzed the effects of naturally occurring levels of AFB1 on apoptosis of healthy bovine and camelid neonatal neutrophils (PMN) that were isolated both before and after host consumption of colos...
#1Ali Ghorbani Ranjbary (FUM: Ferdowsi University of Mashhad)
#2Jalil Mehrzad (UT: University of Tehran)H-Index: 21
Last. Saman Hosseinkhani (TMU: Tarbiat Modares University)H-Index: 28
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Colorectal cancer (CRC) is an increasingly common medical issue affecting millions worldwide, and contribution of the body’s trace elements to CRC is arguable. The concentrations and buffered status of selenium, iron, copper, zinc, and phosphorus in blood and large intestinal tissues of CRC patients are, respectively, variable and vital for cell physiology. The aim of this study was to assess selenium, iron, copper, zinc, and phosphorus variations in blood and colorectal epithelia along with exa...
#1Meisam JafarzadehH-Index: 4
Last. Saman HosseinkhaniH-Index: 28
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Abstract Recent advances have revealed that lncRNAs play important roles in tumorigenesis. However, only a small number of functional lncRNAs have been well characterized, particularly in colorectal cancer. Therefore, more extensive studies are needed to identify and characterize these lncRNAs to better understand cancer progression. In the present study, using available RNA-seq data, we found that LINC02381 (NR_026656.1) differentially expresses in CRC tissues compared to normal pairs. Consiste...
#1Roya Cheraghi (TMU: Tarbiat Modares University)H-Index: 4
#2Mahboobeh Nazari (Avicenna Research Institute)H-Index: 9
Last. Saman Hosseinkhani (TMU: Tarbiat Modares University)H-Index: 28
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Gene-based therapy largely relies on the vector type that allows a selective and efficient transfection into the target cells with maximum efficacy and minimal toxicity. Although, genes delivered utilizing modified viruses transfect efficiently and precisely, these vectors can cause severe immunological responses and are potentially carcinogenic. A promising method of overcoming this limitation is the use of non-viral vectors, including cationic lipids, polymers, dendrimers, and peptides, which ...
#1Sadat Dokanehiifard (TMU: Tarbiat Modares University)H-Index: 4
#2Bahram Mohammad Soltani (TMU: Tarbiat Modares University)H-Index: 10
Last. Saman Hosseinkhani (TMU: Tarbiat Modares University)H-Index: 28
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Abstract Dispose of unnecessary cells in multicellular organism take place through apoptosis as a mode of programmed cell death (PCD). This process is triggered through two main pathway including extrinsic pathway or death receptor pathway and intrinsic or mitochondrial pathway. An alternative role for mitochondrial pathway of cell death is its involvement in cell differentiation. Biochemistry of cell differentiation indicates a common origin for differentiation and apoptosis. miRNAs are a group...
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